Publications by authors named "Jinghui Bi"
Background: Kidney stones are a chronic metabolic disorder. The cardiometabolic index (CMI) is a new and easily accessible measure used to assess metabolic status. However, the relationship between CMI and the incidence of kidney stones remains unclear.
View Article and Find Full Text PDFBackground: 1,2,3,4,6-Penta-O-galloyl-β-D-glucose (β-PGG) is a polyphenol ellagic compound with a variety of pharmacological effects and has an inhibitory effect on lots of cancers.
Objective: To explore the antitumor effects and mechanism of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose on human hepatocellular carcinoma HepG2 cells.
Design: A network pharmacology method was first used to predict the possible inhibition of hepatocellular carcinoma growth by 1,2,3,4,6-Penta-O-galloyl-β-D-glucose (β-PGG) through the p53 signaling pathway.
Article Synopsis
- - Gastric cancer is a major cause of cancer-related deaths globally, and the compound 1,2,3,4,6-Pentagalloyl-β-D-glucose (β-PGG) shows promise in suppressing its development, although its mechanisms are not fully understood.
- - The study utilized network pharmacology and experimental methods to identify key targets and mechanisms of β-PGG, focusing on its effects on cell cycle and apoptosis in gastric cancer cells.
- - Results revealed that β-PGG inhibits cancer cell proliferation and induces cell cycle arrest and apoptosis through modulation of the p53 signaling pathway, indicating its potential for developing treatments for gastric cancer.