UBE2C mediates follicular thyroid carcinoma invasion and metastasis via K29-Specific vimentin ubiquitination.

Follicular thyroid carcinoma (FTC) poses significant clinical challenges due to its vascular invasion tendency and distant metastasis potential, leading to poorer patient outcomes compared to other thyroid carcinomas. Although ubiquitin-conjugating enzyme E2C (UBE2C) has been widely studied in various cancers, its specific role in FTC progression remains insufficiently explored. This study demonstrates UBE2C's dual functionality in FTC through clinical analysis and experimental validation.

Mechanical forces and enzymatic digestion act together to induce the remodeling of collagen fibrils in tumor microenvironment.

Cancer is a serious disease in human beings, and its high lethality is mainly due to the invasion and metastasis of cancer cells. Clinically, the accumulation and high orientation of collagen fibrils were observed in cancerous tissue, which occurred not only at the location of invasion but also at 10-20 cm from the tumor. Studies indicated that the invasion of cancer cells could be guided by the oriented collagen fibrils, even in a dense matrix characterized by difficulty degradation.

Evaluative Methodology for HRD Testing: Development of Standard Tools for Consistency Assessment.

Homologous recombination deficiency (HRD) has emerged as a critical prognostic and predictive biomarker in oncology. However, current testing methods, especially those reliant on targeted panels, are plagued by inconsistent results from the same samples. This highlights the urgent need for standardized benchmarks to evaluate HRD assay performance.

A sensor-actuator-coupled gustatory interface chemically connecting virtual and real environments for remote tasting.

Recent advancements in virtual reality (VR) and augmented reality (AR) have strengthened the bridge between virtual and real worlds via human-machine interfaces. Despite extensive research into biophysical signals, gustation, a fundamental component of the five senses, has experienced limited progress. This work reports a bio-integrated gustatory interface, "e-Taste," to address the underrepresented chemical dimension in current VR/AR technologies.

Clinical features of autoimmune cerebellar ataxia related to neuronal antibodies.

Objective: This study aimed to investigate the clinical features of neuronal antibodies related to autoimmune cerebellar ataxia (ACA) and to provide guidance for the diagnosis and treatment of this disease.

Methods: Demographic and clinical data were collected from antibody-positive patients with ACA who were admitted to the Department of Neurology, Affiliated Hospital of Hebei University, from January 2018 to February 2023. A retrospective analysis on the clinical manifestations, laboratory examinations, imaging data, treatment, and prognosis was performed.

Association between family disharmony, maternal negative emotional states, and behavioral problems among Chinese children attending preschools.

Background: Although previous studies have shown that children from disharmonious families were more likely to exhibit behavioral problems, the underlying pathways remain unclear. This study aimed to assess the associations between family disharmony and behavioral problems among Chinese preschool children and to investigate the potential mediating role of maternal negative emotional states.

Methods: A cross-sectional study including 4243 preschool children and their mothers was conducted in Chengdu, China.

MOF-derived Cu@CuO nanoclusters for photothermally enhanced Fenton-like catalytic degradation of dye pollutants.

This paper presents a synthesis method for a novel octahedral Cu@CuO nanocluster (NAs), which is prepared by calcining Cu-BTC (metal-organic framework, 1,3,5-benzenetricarboxylate) in air, resulting in a porous carbon structure. The obtained Cu@CuO nanoclusters exhibit heterogeneous interfaces between Cu and CuO, significantly enhancing their Fenton-like catalysis and photothermal properties. Using SEM, TEM, XPS, and XRD techniques, the Cu@CuO NAs were comprehensively characterized.

Network analysis of adverse childhood experiences and problematic internet use among Chinese adolescents.

Background: The association between adverse childhood experiences (ACEs) and problematic internet use (PIU) in adolescents has received increasing attention. However, item-level associations between ACEs and PIU remained underexplored. This study utilized network analysis to explore these complex interactions and enhance understanding of the linking pathways.

Loneliness and health-related quality of life in Chinese adolescents: the mediating role of depressive symptoms and the moderating role of age.

Purpose: Despite the alarming prevalence of loneliness in adolescents, few studies addressed its impact on health-related quality of life (HRQOL). This study aimed to investigate the association between loneliness and HRQOL in adolescents, as well as the mediating role of depressive symptoms and the moderating role of age in this association.

Methods: A cross-sectional study surveyed 6743 middle school adolescents, assessing loneliness with the 6-item UCLA Loneliness Scale and HRQOL through the Pediatric Quality of Life Inventory Version 4.

Self-Reported Long COVID and Its Impact on COVID-19-Related Worries and Behaviors After Lifting the COVID-19 Restrictions in China.

Objective: Since the lifting of the COVID-19 restrictions in China in November 2022, there has been a notable surge in the COVID-19 infection rate. Little is known about the prevalence of long COVID among the general adult population and its impact on COVID-19-related worries and behaviors after the policy change.

Methods: This cross-sectional study recruited 1530 adults with prior COVID-19 infection in Guangzhou from February to March 2023.

Characterization and genomic analysis of Cronobacter sakazakii phage JC03, a new member of the genus Pseudotevenvirus.

The Cronobacter sakazakii-infecting phage JC03 was isolated and characterized. Its genome is composed of 177,089 bp of double-stranded DNA, contains 268 predicted open reading frames (ORFs) and two tRNA genes, and it has a G + C content of 44.67%.

Short-Term Mobility and Risky Sexual Behaviors Among Men Who Have Sex with Men in Guangdong, China.

This study investigated regional differences in short-term mobility patterns among men who have sex with men (MSM) in Guangdong Province, and explored the associations with risky sexual behaviors. An online survey was conducted from June to August 2023, collecting socio-demographic information, intra-provincial mobility details and sexual behaviors. Among 1,808 participants, 60% reported moving within the province over the past six months, primarily for tourism, business/work, or visiting family and friends.

Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study.

Taste preference drives food selection, acceptance, or rejection and influences nutritional status and body mass index. Nevertheless, there are few reports concerning pregnant women. Mala flavor, characterized by its "numbing" and "spicy" sensations, is a distinctive taste of Sichuan cuisine, created by the combination of Chinese prickly ash and chili peppers.

Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair.

Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM).

Effects of infection on neonates: a meta-analysis.

Objective: (UU) is an opportunistic pathogen transmitted from mother to fetus, potentially causing neonatal diseases. Despite extensive research, its association with these diseases remains uncertain. This study analyzes the effects of UU infection on newborns.

Association between Multimorbidity and End-of-Life Outcomes among Middle-Aged and Older Adults: Evidence from 28 Countries.

Objectives: Multimorbidity poses significant challenges to the well-being of middle-aged and older adults, but its impact on end-of-life experiences remains relatively underexplored and inconsistent. This study aims to investigate the association between the number of chronic conditions and 6 end-of-life outcomes across 28 countries.

Design: Longitudinal analyses.

Ultrathin, Lightweight Materials Enabled Wireless Data and Power Transmission in Chip-Less Flexible Electronics.

The surge of flexible, biointegrated electronics has inspired continued research efforts in designing and developing chip-less and wireless devices as soft and mechanically compliant interfaces to the living systems. In recent years, innovations in materials, devices, and systems have been reported to address challenges surrounding this topic to empower their reliable operation for monitoring physiological signals. This perspective provides a brief overview of recent works reporting various chip-less electronics for sensing and actuation in diverse application scenarios.

Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing.

Hydrogels possessing appropriate adhesion and antibacterial properties have emerged as promising dressings for expediting wound healing, while also providing the convenience of visualizing the wound site to accurately monitor the healing process. In this study, we incorporated oxidized and degraded polydopamine nanoparticles into quaternized chitosan/oxidized dextran hydrogel QOP series, resulting in enhanced transmittance exceeding 95 % and adhesion strengths reaching up to 19.4 kPa.

Erratum: Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy: Erratum.

[This corrects the article DOI: 10.7150/thno.22557.

4-1BBL-Armed Oncolytic Herpes Simplex Virus Exerts Antitumor Effects in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a notably poor response to therapy due to its immunosuppressive tumor microenvironment (TME) and intrinsic drug resistance. The oncolytic virus (OV) represents a promising therapeutic strategy capable of transforming the "cold" immunological profile of PDAC tumors to a "hot" one by reshaping the TME. 4-1BB (CD137), a crucial member of the tumor necrosis factor receptor superfamily, plays a significant role in T-cell activation and function.

Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion.

: Postoperative abdominal adhesion is a prevalent complication following abdominal surgery, with the incidence of adhesion reaching up to 90%, which may precipitate a range of adverse outcomes. Although fibrous membranes loaded with various anti-inflammatory or other drugs have been proposed for anti-adhesion, most of them suffer from drug-induced adverse effects. : In this study, a lecithin-based electrospun polylactic acid (PLA) nanofibrous membrane (L/P-NM) was developed for the prevention of postoperative abdominal adhesion, utilizing the hydration lubrication theory.

NIR-Activated Hydrogel with Dual-Enhanced Antibiotic Effectiveness for Thorough Elimination of Antibiotic-Resistant Bacteria.

Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents can cause severe systemic toxicity. Here, we have developed a dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which can achieve controlled release of clinical antibiotics levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant .

RNF5 exacerbates steatotic HCC by enhancing fatty acid oxidation via the improvement of CPT1A stability.

Non-alcoholic fatty liver disease (NAFLD) is expected to become the leading risk factor for liver cancer, surpassing viral hepatitis. Unlike viral hepatitis-related hepatocellular carcinoma (HCC), the role of excessive nutrient supply in steatotic HCC is not well understood, hindering effective prevention and treatment strategies. Therefore, it is crucial to identify key molecules in the pathogenesis of steatotic HCC, investigate changes in metabolic reprogramming due to excessive fatty acid (FA) supply, understand its molecular mechanisms, and find potential therapeutic targets.