Publications by authors named "Jinghua Huang"
Article Synopsis
- The study investigates high rates of AIDS and mortality among HIV-infected individuals in Guangxi, focusing on factors that impair CD4+ cell recovery.
- A significant 52.44% of participants were identified as immunological non-responders after two years of treatment, with age, gender, education, occupation, and HIV subtype affecting recovery outcomes.
- The research emphasizes the importance of closely monitoring those with low pre-treatment CD4+ counts, as non-response is linked to increased mortality and faster disease progression.
Article Synopsis
- The study examines the rising cases of HIV/AIDS among youth in Guangxi, China, focusing on how these cases have changed from 2014 to 2021 to inform prevention strategies.
- It analyzes data from a comprehensive health information system, looking at factors like population density and economic indicators using tools like ArcGIS and Bayesian spatiotemporal modeling.
- Findings show that youth HIV/AIDS incidence peaked in 2019, with significant associations between higher cases and factors like population density, while road mileage negatively correlated with reported incidences.*
Article Synopsis
- The study explored the patterns of pretreatment (PDR) and acquired drug resistance (ADR) in HIV-1 sequences in China, using data from various databases.
- Analysis of over 36,000 sequences from ART-naïve individuals revealed a PDR prevalence of 6.64%, which increased to 7.84% between 2018 and 2022 due to NNRTI, while ADR prevalence reached 44.96%.
- Findings showed that PDR was primarily high in Central China and ADR in North China, with distinct patterns of drug resistance mutations appearing across various HIV-1 subtypes, highlighting the need for ongoing monitoring and patient education.
Impact of HIV-1 genetic diversity on disease progression: a prospective cohort study in Guangxi.
Front Cell Infect Microbiol
July 2024
Article Synopsis
- The study investigates the impact of HIV-1 genetic diversity on AIDS progression in Guangxi, revealing high AIDS cases and mortality rates in the region.
- Data was collected from newly diagnosed patients over six years, analyzing factors affecting CD4+ T lymphocyte counts and recovery using various statistical models.
- Key findings indicate that certain demographics and HIV-1 subtypes, particularly CRF01_AE, are linked to lower immune cell recovery and higher mortality, emphasizing the complex nature of HIV infection in this area.
Article Synopsis
- Scientists studied breast cancer patients to understand how certain genetic changes (mutations) and a problem called homologous recombination deficiency (HRD) happen in the disease.
- They found that patients with specific mutations had higher HRD scores, especially in a group with severe HRD (HRD-high), which also showed different genetic changes compared to those with low HRD (HRD-low).
- The research suggests that these specific mutations can help predict which patients might respond better to certain treatments for breast cancer.
Background: To date, although most thyroid carcinoma (THCA) achieves an excellent prognosis, some patients experience a rapid progression episode, even with differentiated THCA. Nodal metastasis is an unfavorable predictor. Exploring the underlying mechanism may bring a deep insight into THCA.
View Article and Find Full Text PDFThe development of the embryo sac is an important factor that affects seed setting in rice. Numerous genes associated with embryo sac (ES) development have been identified in plants; however, the function of the DEAD-box RNA helicase family genes is poorly known in rice. Here, we characterized a rice DEAD-box protein, RH52A, which is localized in the nucleus and cytoplasm and highly expressed in the floral organs.
View Article and Find Full Text PDFArticle Synopsis
- * Out of 491 participants, 396 were successfully analyzed, revealing that 52.53% had HIV DRMs, with the most common mutations linked to NNRTI and NRTI classes, and a significant incidence of dual-class resistance.
- * Factors such as being male, having a specific HIV subtype, using certain treatment regimens, low CD4+ counts, and high viral loads were associated with a higher likelihood of developing DRMs, highlighting the need for
Objectives: To assess the profiles and determinants of drug resistance in HIV-1-infected individuals undergoing ART in Guangxi.
Methods: Samples and data were collected from HIV-1-infected individuals experiencing virological failure post-ART from 14 cities in Guangxi. Sequencing of the HIV-1 pol gene was conducted, followed by analysis for drug resistance mutations using the Stanford University HIV Drug Resistance Database.
Breast cancers involving mutations in homologous recombination (HR) genes, most commonly BRCA1 and BRCA2 (BRCA1/2), respond well to PARP inhibitors and platinum-based chemotherapy. However, except for these specific HR genes, it is not clear which other mutations contribute to homologous recombination defects (HRD). Here, we performed next-generation sequencing of tumor tissues and matched blood samples from 119 breast cancer patients using the OncoScreen Plus panel.
View Article and Find Full Text PDFEvidence indicated that emojis could influence sarcasm comprehension and sentence processing in English. However, the effect of emojis on Chinese sarcasm comprehension remains unclear. Therefore, this study investigated the impact of the smiley emoji position and semantics on eye movements and subjective assessments during Chinese online communication.
View Article and Find Full Text PDFThe diversity and transmission patterns of major HIV-1 subtypes among MSM population in Guangxi remains unknown. Understanding the characteristics is crucial for effective intervention strategies. Between 2016 and 2021, we recruited individuals newly diagnosed with HIV-1 from MSM population in Guangxi.
View Article and Find Full Text PDFWhat Is Already Known About This Topic?: The effects of concurrent human immunodeficiency virus (HIV)/hepatitis C virus (HCV) infection on mortality and patient attrition in those undergoing antiretroviral therapy continue to be a contested area of research.
What Is Added By This Report?: According to the propensity score-matched cohort, individuals with HIV/HCV co-infection exhibit an elevated risk of all-cause mortality [adjusted hazard ratio: 2.048, 95% confidence interval (): 1.
Article Synopsis
- - The study examined how different levels of soil erosion (light, moderate, heavy) affect the hydraulic properties of black soil in slope farmlands, focusing on factors such as saturated hydraulic conductivity and water capacity.
- - Results indicated that as soil erosion increased, the saturated hydraulic conductivity, water holding capacity, and water supply capacity declined, with greater impacts seen in the topsoil compared to the subsoil.
- - The decrease in soil organic matter and the increase in soil bulk density were identified as key factors causing reduced water retention, highlighting the importance of understanding these changes for better soil management and erosion prevention.
Background: The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment. Macrophage is an important component of the innate and adaptive immunity, and its unique phagocytic function has been explored to construct CAR macrophages (CAR-Ms) against solid tumors. This study aimed to investigate the therapeutic application of CAR-Ms in ovarian cancer.
View Article and Find Full Text PDFModelling the impact of treatment adherence on the transmission of HIV drug resistance.
J Antimicrob Chemother
August 2023
Article Synopsis
- Lower adherence rates to antiretroviral therapy (ART) can lead to increased drug resistance, reduced treatment effectiveness, and higher mortality rates, emphasizing the need to study adherence's impact on HIV transmission.
- A dynamic model was used to analyze the interplay between diagnosis, treatment, adherence, and drug resistance, using data from Guangxi, China, to assess how adherence affects new infections and deaths related to HIV.
- Results indicate that while increasing ART coverage can reduce new infections and deaths, low adherence rates can negate these benefits, highlighting the importance of maintaining high adherence among those currently treated.
What Is Already Known About This Topic?: Migration has a significant impact on the transmission of human immunodeficiency virus (HIV). To date, there have been few studies examining the characteristics of migration among HIV-positive men who have sex with men (MSM).
What Is Added By This Report?: The prevalence of migrants among newly reported HIV-positive MSM in Guangxi Zhuang Autonomous Region increased from 2005 to 2021.
Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China.
Child Adolesc Psychiatry Ment Health
April 2023
Background: Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes.
Methods: This cross-sectional study was conducted in Guangxi, China, between July and August 2021.
Background: In Guangxi province of China, there is a high prevalence of HIV in the general population and in men who have sex with men (MSM). However, there is still a low proportion of MSM among people living with HIV. This apparent contradiction could be due to the high proportion of potential non-disclosed MSM (pnMSM) among reported heterosexual men.
View Article and Find Full Text PDFBackground: Attrition due to loss to follow-up or termination of antiretroviral therapy (ART) among HIV-infected patients in care may increase the risk of emergence and transmission of drug resistance (TDR), diminish benefit of treatment, and increase morbidity and mortality. Understanding the impact of attrition on the epidemic is essential to provide interventions for improving retention in care.
Methods: We developed a comprehensive HIV transmission dynamics model by considering CD4 + cell count dependent diagnosis, treatment, and attrition involving TDR and acquired drug resistance.
Background: Nearly one-third of new HIV infections occurred among youth in 2019 worldwide. Previous studies suggested that student youths living with HIV and nonstudent youths living with HIV might differ in some risk factors, transmission routes, HIV care, and disease outcomes.
Objective: This study aimed to compare the HIV epidemic, disease outcomes, and access to care among student and nonstudent youths living with HIV aged 16 to 25 years in Guangxi, China.
Background: The prevalence of human immunodeficiency type 1 (HIV-1) pretreatment drug resistance (PDR) in men who have sex with men (MSM) in Guangxi remains unclear, and its effect on antiretroviral therapy (ART) needs to be further studied.
Methods: Individuals newly diagnosed with HIV in Guangxi from 2016 to 2020, which mainly included MSM and the heterosexual (HES) population, were recruited in this study. Pol sequences were sequenced to analyze PDR and construct a genetic network.
Composting is an important decentralized technology for treating multiple biodegradable organic wastes in rural areas. However, compared to industrial composting (i.e.
View Article and Find Full Text PDFArbuscular mycorrhizal fungi (AMF) widely exist in the soil ecosystem. It has been confirmed that AMF can affect the root exudates of the host, but the chain reaction effect of changes in the root exudates has not been reported much. The change of soil microorganisms and soil enzyme vigor is a direct response to the change in the soil environment.
View Article and Find Full Text PDFThe Integrated Microbial Genomes & Microbiomes system (IMG/M: https://img.jgi.doe.
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