Publications by authors named "Jinghua Fan"

In August 2022, melon (), cucumber () and luffa () plants showed virus-like symptoms characteristic of geminiviruses (yellowish green, mosaic patterns and severe curling of leaves, short internodes, and stunting) in 10 greenhouses in Fengxian district and 20 greenhoues in Jiading district of Shanghai, China. Fifty symptomatic leaf samples were randomly collected: 28 from melon, 17 from cucumber, and 5 from luffa. To investigate the etiology of the observed disease, total DNA and RNA was extracted via a DNA extraction kit (Tiangen, Not: DP350) and TRIzol reagent (Sigma-Aldrich, Not: T9424), respectively.

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Dual-hereditary jaundice (Dubin-Johnson syndrome (DJS) and Gilbert's syndrome (GS)) is a rare clinical entity resulting from defects of the ATP binding cassette subfamily C member 2 (ABCC2) and UDP glucuronosyltransferase family 1 member A1 (UGT1A1) genes with autosomal recessive inheritance. In this study, we aimed to investigate the mutation profiles and characterize the phenotypes in a Han Chinese family with DJS and GS. Genetic screening for variants in the ABCC2 and UGT1A1, immunohistochemistry for expression of ABCC2, and histopathological examination were carried out.

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Article Synopsis
  • Xanthomatous hypophysitis (XHP) is a rare condition primarily affecting women around age 39, often presenting with headaches and menstrual disorders.
  • Most patients have significant pituitary dysfunction, particularly growth hormone deficiency, with central diabetes insipidus being common.
  • Surgical removal of the lesion is the preferred treatment, showing high resolution rates for hormone abnormalities, but the long-term outcomes for XHP remain uncertain.
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Background: Vaginal paraganglioma are rare, atypical, solitary tumors which originate from the female genital tract. Sacrococcygeal teratoma are also rare neoplasms which derive from one (or more) primordial germ cell layers. Here we report a unique case of vaginal paraganglioma with sacrococcygeal teratoma.

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To assess the heterogeneity of HBV reverse transcriptase (RT) quasispecies during 10 years of antiviral therapy and their association with antiviral efficacy. Nineteen patients with chronic hepatitis B (CHB) infection receiving nucleos(t)ide analogues (NAs) were enrolled. Based on the antiviral efficacy after 1 year of treatment, 5 patients were grouped into an early virologic response (EVR) group, while 8 patients were grouped into a late virologic response (LVR) group.

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Background: Melanoma is aggressive and lethal melanocytic neoplasm, and its incidence has increased worldwide in recent decades. Accumulating evidence has showed that various long noncoding RNAs (lncRNAs) participated in occurrence of malignant tumors, including melanoma. The present study was designed to investigate function of lncRNA colon cancer-associated transcript-1 (CCAT1) in melanoma.

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Article Synopsis
  • Shikonin, derived from the herb Lithospermum erythrorhizon, exhibits antimicrobial, anti-inflammatory, and antitumor properties and was studied for its effects on HaCaT cell apoptosis.
  • Treatment with shikonin resulted in decreased cell viability, induced G0/G1 phase cell cycle arrest, and triggered apoptosis through changes in mitochondrial function and oxidative stress.
  • The study found that shikonin activates markers associated with apoptosis while inhibiting key signaling pathways (Erk and Akt), suggesting its potential use in therapies for skin diseases.
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Although the T241M polymorphism in the X-ray cross-complementing group 3 (XRCC3) gene has been implicated in the pathogenesis of melanoma, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association of XRCC3 T241M polymorphism with melanoma. Published literature from PubMed and Embase databases was retrieved.

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Objective: To study the best time of taking liver biopsy for chronic HBV carriers of age ranges and then guiding antiretroviral treatment.

Method: The liver biopsy pathologic results of 292 cases of chronic HBV carriers were collected from the First Affiliated Hospital of Kunming Medical College. The patients were divided into three groups according to ages.

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Calcium water treatment residue (Ca-WTR), an industrial by-product, was found to be effective in decreasing Cu availability in contaminated soils and transport to the environment. In this study, a greenhouse study was conducted to test the ability of Ca-WTR to reduce the toxicity and uptake of Cu by ryegrass (Lolium perenne L.) and lettuce (Lactuca sativa L.

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In the process of mining activity, many kinds of heavy metals enter into soils with dust, causing serious contamination to the environment. In this study, six soils were sampled from cropland at different distances from a lead/zinc mine in Heilongjiang Province, China. The total contents of lead and zinc in the vicinal cropland exceeded the third level of environmental quality standard for soil in China, which indicated that soils in this area were moderately contaminated.

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Chemical remediation has attracted increasing attention for heavy metal contaminated soils because of its relatively low cost and high efficiency. In this study laboratory incubation and column leaching experiments were conducted to understand the mechanisms of copper (Cu) immobilization by calcium water treatment residue (Ca-WTR) and to estimate the optimal rate for remediating Cu-contaminated soils. The results showed that Ca-WTR amendment significantly raised soil pH and decreased water soluble and exchangeable Cu by 62-90% in the contaminated soils.

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In this study, Streptomyces roseosporus was subjected to helium-neon (He-Ne) laser (632.8 nm) irradiation to improve the production ability of extracellular antibiotic daptomycin. Under the optimum irradiation dosage of 18 mW for 22 min, a stable positive mutant strain S.

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To investigate whether resveratrol could restore the lysophosphatidylcholine (LPC)-induced loss of endothelium-dependent relaxation in in vitro cultured rat aorta tissue, first the effect of resveratrol on the loss of EDR was examined in this preparation. The results showed that resveratrol effectively attenuated the inhibition of LPC (10 μM) on both endothelium-derived relaxing factor (EDRF) and endothelium-derived hyperpolarizing factor (EDHF) in a concentration-dependent manner (1, 10, 100 μM). In addition, resveratrol inhibited elevated K+-induced vascular contracture, but had no significant effects on ACh (1 μM)-induced endothelium-dependent relaxation (EDR).

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Ethnopharmacological Relevance: Modified Si-Miao-San (mSMS) is a prescription modified from Si-Miao-San which is an ancient Chinese prescription used to treat various ailments.

Aim Of The Study: Modified Si-Miao-San (mSMS) has been used for the treatment of infectious and inflammatory disorders in the clinic. This study was aimed to investigate its anti-inflammatory activity and underlying mechanism at cellular and molecular levels.

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By increasing particle concentration and G value (root-mean-square velocity gradient) to enhance flocculation, a novel vertical-flow settler was designed to increase sedimentation effectiveness, and to simultaneously improve operational stabilization. Due to the gradual decrease in upward flow-rate of raw water, a flocs blanket would form and suspend in the middle section of the settler, not at the bottom as in a conventional clarifier. Enough large flocs, resulted from flocculation or filtration, would continuously settle out of the flocs blanket, and simultaneously, the flocs in raw water or those forming above the blanket would ceaselessly enter the flocs blanket.

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A study on electrochemical hydrodehalogenation of pentachloraphenol in aqueous solutions was conducted on porous titanium loaded Pd cathode and the operational parameters were investigated. Chloride ions and phenol is the main products analyzed by GC-MS. Up to 100% electrochemical hydrodehalogenation can be achieved with more than 90% conversion to phenol.

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We investigated performances as well as influencing factors of electrocatalytic denitrification of a porous titanium loaded Pd-Cu (4:1) cathode, from drinking water. Up to 96.9% of NO3(-)-N may be reduced to N2 with electrocatalytic activity as 16.

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The effect of acidification and heat treatment of raw red mud (RM) and fly ash (FA) on the sorption of phosphate was studied in parallel experiments. The result shows that a higher efficiency of phosphate removal was acquired by the activated samples than by the raw ones. The sample prepared by using the RM stirred with 0.

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Polyaluminum coagulant with a content of 76.8% of Al30 (PACAl30) was prepared. Its coagulation behaviors were compared with high Al13 content polyaluminum coagulant (PACAl13) and AlCl3.

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Rice blast caused by Pyricularia grisea is the most destructive disease in Yunnan Plateau, China. In order to elucidate the relationship between genetic lineage and pathotype of P. grisea of Yunnan Plateau as well as the variability of the fungus at DNA level,the repetitive element-based PCR (rep-PCR) of Pot2, an element found in approximately 100 copies in the fungus genome,was exploited.

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