A high performance Pb(II) electrochemical sensor based on spherical CuS nanoparticle anchored g-CN.

A new electrochemical sensor has been constructed for ultra-sensitive detection of lead ions (Pb) by square wave anodic stripping voltammetry (SWASV), based on the copper sulfide/graphitic carbon nitride nanocomposite modified glassy carbon electrode (CuS/g-CN/GCE). First, spherical CuS nanoparticles with good electrical conductivity were anchored on layered g-CN with high coordination activity, affording an excellent electrode modifier CuS/g-CN nanocomposite. Then, the performance of the CuS/g-CN/GCE and its electrochemical response to Pb were thoroughly studied, and the sensing mechanism was investigated.

Synergetic Sensing Effect of Sodium Carboxymethyl Cellulose and Bismuth on Cadmium Detection by Differential Pulse Anodic Stripping Voltammetry.

In the present work, a novel electrochemical sensor was developed for the detection of trace cadmium with high sensitivity and selectivity in an easy and eco-friendly way. Firstly, a glassy carbon electrode (GCE) was modified with nontoxic sodium carboxymethyl cellulose (CMC) by a simple drop-casting method, which was applied to detect cadmium by differential pulse anodic stripping voltammetry (DPASV) in a solution containing both target cadmium and eco-friendly bismuth ions, based on a quick electro-codeposition of these two metal ions on the surface of the modified electrode (CMC-GCE). Investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FT-IR), both CMC (with good film-forming ability) and bismuth (with well-defined stripping signal) were found to be well complexed with target cadmium, leading to vital signal amplification for cadmium detection at a sub-nanomolar level.

A Water-soluble Fluorescent Probe for Rapid Detection of Sulfur Dioxide Derivatives.

The content of sulfur dioxide derivatives in cells is closely related to life and health. Therefore, it is essential to detect the content of sulfur dioxide derivatives in cells under physiological conditions to ensure life and health. In this paper, a novel sulfur dioxide derivative fluorescent water-soluble probe ((E)-1,1,3-trimethyl-2-(2-(naphthalen-1-yl)vinyl)-1H-3λ-benzo[e]indole, TNB) was synthesized by using naphthalene formaldehyde (1) and 1,1,2,3-tetramethyl-1H-3λ-benzo[e]indole (2) as raw materials.

A new indicator of ionic polymeric flocculants for the removal of heavy metals anions: Specific charge density.

Ionic polymeric flocculants, as useful and widely used technology, have been applied for heavy metal pollution control. However, although molecular weight is an important indicator, it is not a comprehensive indicator for evaluating flocculation efficiencies of ionic flocculants. Herein, specific charge density (SCD), defined as charge density of unit molecular weight, is a new indicator to evaluate the performance of ionic polymer flocculants.

Abnormal Anionic Porphyrin Sensing Effect for HER2 Gene Related DNA Detection via Impedance Difference between MWCNTs and Single-Stranded DNA or Double-Stranded DNA.

Human epidermal growth factor receptor 2 (HER2) is a key tumor marker for several common and deadly cancers. It is of great importance to develop efficient detection methods for its over-expression. In this work, an electrochemical impedance spectroscopy (EIS) method adjustable by anionic porphyrin for HER2 gene detection has been proposed, based on the impedance difference between multi-walled carbon nanotubes (MWCNTs) and DNA.

Ultrasensitive Electrochemical Sensor Based on Polyelectrolyte Composite Film Decorated Glassy Carbon Electrode for Detection of Nitrite in Curing Food at Sub-Micromolar Level.

To ensure food quality and safety, developing cost-effective, rapid and precision analytical techniques for quantitative detection of nitrite is highly desirable. Herein, a novel electrochemical sensor based on the sodium cellulose sulfate/poly (dimethyl diallyl ammonium chloride) (NaCS/PDMDAAC) composite film modified glass carbon electrode (NaCS/PDMDAAC/GCE) was proposed toward the detection of nitrite at sub-micromolar level, aiming to make full use of the inherent properties of individual component (biocompatible, low cost, good electrical conductivity for PDMDAAC; non-toxic, abundant raw materials, good film forming ability for NaCS) and synergistic enhancement effect. The NaCS/PDMDAAC/GCE was fabricated by a simple drop-casting method.

SiO₂ Stabilized Magnetic Nanoparticles as a Highly Effective Catalyst for the Degradation of Basic Fuchsin in Industrial Dye Wastewaters.

Catalytic degradation of organic pollutants by nanomaterials is an effective way for environmental remediation. The Fenton reaction involving H₂O₂ oxidation catalysed by Fe is an advisable way for wastewater degradation. Herein, Fe₃O₄/SiO₂ core-shell nanoparticles were prepared as catalyst by coprecipitation and sol-gel methods, and this catalyst is used for degradation of fuchsin in wastewater by H₂O₂.

Rapid and Sensitive Determination of Vanillin Based on a Glassy Carbon Electrode Modified with Cu₂O-Electrochemically Reduced Graphene Oxide Nanocomposite Film.

A facile cuprous oxide nanoparticles functionalized electro-reduced graphene oxide modified glassy carbon electrode (denoted as Cu₂O NPs-ERGO/GCE) was fabricated via a simple physical adsorption and electrochemical reduction approach. Cyclic voltammetry and second-order derivative linear scan voltammetry were used to investigate the electrocatalysis oxidation of vanillin on the Cu₂O NPs-ERGO/GCE. The compound yielded a well-defined voltammetric response in 0.

Mapping inhibitor response to the in-frame deletions, insertions and duplications of epidermal growth factor receptor (EGFR) in non-small cell lung cancer.

Human epidermal growth factor receptor (EGFR) has become a well-established target for the treatment of non-small cell lung cancer (NSCLC). However, a large number of in-frame deletion, insertion and duplication mutations in the EGFR tyrosine kinase (TK) domain have been observed to alter drug response to such a kinase target. Thus, a systematic investigation of the intermolecular interactions between the clinical small-molecule agents and various EGFR in-frame mutants would help to establish a complete picture of drug response to kinase mutations in lung cancer, and to design new EGFR inhibitors with high potency and selectivity to target drug-resistant mutants.

Structural and energetic insights into sequence-specific interaction in DNA-drug recognition: development of affinity predictor and analysis of binding selectivity.

Although the molecular mechanism and thermodynamic profile of a wide variety of chemical agents have been examined intensively in the past decades in terms of specific recognition of their protein receptors, to date the physicochemical nature of DNA-drug recognition and association still remains largely unexplored. The present study focused on understanding the structural basis, energetic landscape, and biological implications underlying the binding of small-molecule ligands to their cognate or non-cognate DNA receptors. First, a new method to capture the structural features of DNA-drug complex architecture was proposed and then used to correlate the extracted features with binding affinity of the complexes.

3-Bromo-N'-(2-hydr-oxy-3,5-diiodo-benzyl-idene)benzohydrazide monohydrate.

Crystals of the title compound, C(14)H(9)BrI(2)N(2)O(2)·H(2)O, were obtained from a condensation reaction of 3-bromo-benzohydrazide with 3,5-diiodo-salicylaldehyde. The Schiff base mol-ecule assumes an E configuration with respect to the C=N bond, and the dihedral angle between the two benzene rings is 6.9 (2)°.