Genome-wide pan-GPCR cell libraries accelerate drug discovery.

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful drug targets. However, only approximately 15% of the 800 human GPCRs are targeted by market drugs, leaving numerous opportunities for drug discovery among the remaining receptors.

Nanoarchitectured FeC@N-Doped C/FeVO as High-Performance Anode for Sodium-Ion Batteries.

Ferric vanadate exhibits potential as an attractive anode material for sodium-ion batteries (SIBs) due to the multiple oxidation states of vanadium and natural abundances of iron. However, the design and fabrication of high-performance ferric vanadate-based SIB anode materials with unique composite nanostructures are still challenging. Herein, a facile self-template method is reported to synthesize 1D nanostructured FeC@N-doped C/FeVO (FeC@NC/FeVO) anode materials by the combination of morphology regulation with hybrid composite construction, for the first time.

High-capacity K-pillared layered manganese dioxide as cathode material for high-rate aqueous zinc-ion battery.

Sluggish kinetics and severe structural instability of manganese-based cathode materials for rechargeable aqueous zinc-ion batteries (ZIBs) lead to low-rate capacity and poor cyclability, which hinder their practical applications. Pillaring manganese dioxide (MnO) by pre-intercalation is an effective strategy to solve the above problems. However, increasing the pre-intercalation content to realize stable cycling of high capacity at large current densities is still challenging.

Chemical Constituents, Hypolipidemic, and Hypoglycemic Activities of Edgeworthia gardneri Flowers.

The flowers of Edgeworthia gardneri are used as herbal tea and medicine to treat various metabolic diseases including hyperglycemia, hypertension, and hyperlipidemia. This paper investigate the chemical constituents and biological activities of ethanolic extract and its different fractions from E. gardneri flowers.

Development and application of a multi-task oriented deep learning model for quantifying drivers of air pollutant variations: A case study in Taiyuan, China.

Quantitative assessment of the drivers behind the variation of six criteria pollutants, namely fine particulate matter (PM), ozone (O), nitrogen dioxide (NO), sulfur dioxide (SO), particulate matter (PM), and carbon monoxide (CO), in the warming climate will be critical for subsequent decision-making. Here, a novel hybrid model of multi-task oriented CNN-BiLSTM-Attention was proposed and performed in Taiyuan during 2015-2020 to synchronously and quickly quantify the impact of anthropogenic and meteorological factors on the six criteria pollutants variations. Empirical results revealed the residential and transportation sectors distinctly decreased SO by 25 % and 22 % and CO by 12 % and 10 %.

Rice false smut virulence protein subverts host chitin perception and signaling at lemma and palea for floral infection.

The flower-infecting fungus Ustilaginoidea virens causes rice false smut, which is a severe emerging disease threatening rice (Oryza sativa) production worldwide. False smut not only reduces yield, but more importantly produces toxins on grains, posing a great threat to food safety. U.

Stability simulation analysis of targeted puncture in L4/5 intervertebral space for PELD surgery.

The application prospects of percutaneous endoscopic lumbar discectomy (PELD) as a minimally invasive spinal surgery method in the treatment of lumbar disc herniation are extensive. This study aims to find the optimal entry angle for the trephine at the L4/5 intervertebral space, which causes less lumbar damage and has greater postoperative stability. To achieve this, we conduct a three-dimensional simulated analysis of the degree of damage caused by targeted puncture-based trephine osteotomy on the lumbar spine.

Tailoring Phase Fraction Induced Saturation Polarization Delay for High-Performance BaTiO-Based Relaxed Ferroelectric Capacitors.

Electrostatic capacitors based on dielectric materials are essential for enabling technological advances, including miniaturization and integration of electronic devices. However, maintaining a high polarization and breakdown field strength simultaneously in electrostatic capacitors remains a major challenge for industrial applications. Herein, a universal approach to delaying saturation polarization in BaTiO-based ceramic is reported via tailoring phase fraction to improve capacitive performance.

Giant Energy Storage Density with Antiferroelectric-Like Properties in BNT-Based Ceramics via Phase Structure Engineering.

Driven by the information industry, advanced electronic devices require dielectric materials which combine both excellent energy storage properties and high temperature stability. These requirements hold the most promise for ceramic capacitors. Among these, the modulated Bi Na TiO (BNT)-based ceramics can demonstrate favorable energy storage properties with antiferroelectric-like properties, simultaneously, attaching superior temperature stability resulted from the high Curie temperature.

Confusoside from Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway.

Confusoside (CF), a major chemical compound in the leaves of Wall., is a dihydrochalcone glycoside with excellent antioxidant and anti-inflammatory effects. However, the hepatoprotective effect of CF has not been described.

Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Nrf2/NF-κB/caspase signaling pathway.

Dihydrochalcones are important bioactive ingredients in plants. is an edible and medicinal plant, and its leaves are rich in dihydrochalcones. Confusoside (CF) is the most abundant dihydrochalcone in leaves, which is traditionally used in the treatment of liver diseases.

A natural allele of proteasome maturation factor improves rice resistance to multiple pathogens.

Crops with broad-spectrum resistance loci are highly desirable in agricultural production because these loci often confer resistance to most races of a pathogen or multiple pathogen species. Here we discover a natural allele of proteasome maturation factor in rice, UMP1, that confers broad-spectrum resistance to Magnaporthe oryzae, Rhizoctonia solani, Ustilaginoidea virens and Xanthomonas oryzae pv. oryzae.

Delayed Polarization Saturation Induced Superior Energy Storage Capability of BiFeO -Based Ceramics Via Introduction of Non-Isovalent Ions.

Electrostatic capacitors are emerging as a highly promising technology for large-scale energy storage applications. However, it remains a significant challenge to improve their energy densities. Here, an effective strategy of introducing non-isovalent ions into the BiFeO -based (BFO) ceramic to improve energy storage capability via delaying polarization saturation is demonstrated.

Management of massive cerebral infarction as a complication of post-tonsillectomy and analysis of the risk factors: a case report.

Background: The majority of postoperative complications of tonsillectomy are bleeding. However, massive cerebral infarction following haemostasis is a very rare and serious complication and has rarely been reported clinically.

Case Presentation: We performed a left tonsillectomy on a patient with chronic tonsillitis.

Golovinomyces cichoracearum effector-associated nuclear localization of RPW8.2 amplifies its expression to boost immunity in Arabidopsis.

Arabidopsis RESISTANCE TO POWDERY MILDEW 8.2 (RPW8.2) is specifically induced by the powdery mildew (PM) fungus (Golovinomyces cichoracearum) in the infected epidermal cells to activate immunity.

Overproduction of OsRACK1A, an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production, confers rice floral resistance to false smut disease without yield penalty.

Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic stresses. Rice grain production is threatened by the false smut fungus Ustilaginoidea virens, which specifically infects rice floral organs, disrupting fertilization and seed formation. However, little is known about the molecular mechanisms of the U.

Osa-miR160a confers broad-spectrum resistance to fungal and bacterial pathogens in rice.

Rice production is threatened by multiple pathogens. Breeding cultivars with broad-spectrum disease resistance is necessary to maintain and improve crop production. Previously we found that overexpression of miR160a enhanced rice blast disease resistance.

Correction: Xie et al. Preparation and Characterization of New Electrospun Poly(Lactic Acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging. 2022, , 1229.

In the original publication, there was a mistake in Figure 7, as published in [...

miR167d-ARFs Module Regulates Flower Opening and Stigma Size in Rice.

Flower opening and stigma exertion are two critical traits for cross-pollination during seed production of hybrid rice (Oryza sativa L.). In this study, we demonstrate that the miR167d-ARFs module regulates stigma size and flower opening that is associated with the elongation of stamen filaments and the cell arrangement of lodicules.

Spectroscopic Monitoring of the Electrode Process of MnO@rGO Nanospheres and Its Application in High-Performance Flexible Micro-Supercapacitors.

Structural instability is a major obstacle to realizing the high performance of a MnO-based pseudocapacitor material. Understanding its structure transformation in the process of electrochemical reaction, therefore, plays an important role in the efficient enhancement of rate capacity and stability. Herein, a stable MnO@rGO core-shell nanosphere is first synthesized by a liquid-liquid interface deposition further combined with the electrostatic self-assembly method.

Loss and Natural Variations of Blast Fungal Avirulence Genes Breakdown Rice Resistance Genes in the Sichuan Basin of China.

is the causative agent of rice blast, a devastating disease in rice worldwide. Based on the gene-for-gene paradigm, resistance (R) proteins can recognize their cognate avirulence (AVR) effectors to activate effector-triggered immunity. genes have been demonstrated to evolve rapidly, leading to breakdown of the cognate resistance genes.

Preparation and Characterization of New Electrospun Poly(lactic acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging.

Health concerns about food safety have increased in recent years. In order to ensure the safety and increase the shelf-life of food, many methods have been used to slow down the oxidation rate of food fat. In order to solve this problem, a new type of antioxidant-active packaging has emerged.

Blocking Osa-miR1871 enhances rice resistance against Magnaporthe oryzae and yield.

MicroRNAs (miRNAs) play vital roles in plant development and defence responses against various stresses. Here, we show that blocking miR1871 improves rice resistance against Magnaporthe oryzae and enhances grain yield simultaneously. The transgenic lines overexpressing miR1871 (OX1871) exhibit compromised resistance, suppressed defence responses and reduced panicle number resulting in slightly decreased yield.