Phage Therapy: A Promising Treatment Strategy against Infections Caused by Multidrug-resistant Klebsiella pneumoniae.

Klebsiella pneumoniae (KP) is a common and highly pathogenic pathogen, which often causes several serious infections in humans. The rampant and inappropriate use of broad-spectrum antibiotics has fueled a worrisome surge in Multidrug Resistance (MDR) among the strains of K. pneumoniae, which has significantly boosted the risk and complexity of nosocomial infection transmission in clinical settings.

Room Temperature Synthesis of Gradient-Distributed Ni/Fe Sites in Layered Double Hydroxides for Enhanced Oxygen Evolution Reaction.

NiFe-based materials, especially NiFe layered double hydroxides (LDHs), are recognized as the most promising non-precious metal electrocatalysts for alkaline oxygen evolution reaction (OER). However, the precisely designed distribution of active sites for enhancing activities is still significantly restricted due to the lack of reasonable modulation strategies. Herein, sulfur doped Ni/Fe gradient-distributed LDH (GD-NiFe LDH/S) is fabricated by facile air-induced strategy at room temperature.

Dual-bioinspired Janus mesh membrane with controllable bubbles manipulation property for efficient water splitting and pure gas collection.

Water splitting, as a promising clean energy source, has garnered significant attention owing to the escalating global energy crisis. However, prior research has largely focused on electrode materials rather than bubble manipulation, which plays a crucial role in the process. Although using the previously published "Releasing strategy" effectively eliminates micro-sized bubbles from the electrode material for efficient water splitting, the released tiny-sized bubbles pose challenges for controllable and pure collection.

Deciphering the role of NcRNAs in Pancreatic Cancer immune evasion and drug resistance: a new perspective for targeted therapy.

Pancreatic cancer (PC) is a very aggressive digestive system tumor, known for its high mortality rate, low cure rate, low survival rate and poor prognosis. In particular, pancreatic ductal adenocarcinoma (PADC), which accounts for more than 90% of PC cases, has an overall 5-year survival rate of only 5%, which is an extremely critical situation. Early detection and effective treatment of PC is extremely difficult, which leads many patients to despair.

Drug repurposing: An antidiabetic drug Ipragliflozin as Mycobacterium tuberculosis sirtuin-like protein inhibitor that synergizes with anti-tuberculosis drug isoniazid.

The surge of drug-resistant Mycobacterium tuberculosis (DR-TB) impedes the World Health Organization's efforts in ending TB and calls for new therapeutic formulations. M. tuberculosis sirtuin-like protein Rv1151c is a bifunctional enzyme with both deacetylation and desuccinylation activities, which plays an important role in M.

[Spatial and Temporal Characteristics and Driving Force Analysis of Ecological Environmental Quality in Fengfeng Mining Area with Remote Sensing Ecological Index of PM Concentration].

The Fengfeng mining area is an important coal-producing area in China and crucial environmental problems have been caused by large-scale exploitation of coal mines. The spatio-temporal evolution and driving factors of the ecological environment quality in this area must be explored for promoting the transformation of coal-based cities. Based on Landsat data of the Google earth engine （GEE） platform, this study constructed a new remote sensing-based ecological index （RSEInew） for the Fengfeng mining area from 2000 to 2020.

Cross-omics strategies and personalised options for lung cancer immunotherapy.

Lung cancer is one of the most common malignant tumours worldwide and its high mortality rate makes it a leading cause of cancer-related deaths. To address this daunting challenge, we need a comprehensive understanding of the pathogenesis and progression of lung cancer in order to adopt more effective therapeutic strategies. In this regard, integrating multi-omics data of the lung provides a highly promising avenue.

Three new cyclopentanoid monoterpenes from the roots of .

Three new cyclopentanoid monoterpenes, neopiscrocins A-C (-), together with 14 known compounds (-), were isolated from the roots of . The structres of these compounds were elucidated on the basis of their spectroscopic data. All compounds were evaluated for cytotoxicity against six human tumor cell lines (PC9, PANC1, HCT-116, Hep-G2, BGC-823, and MCF-7), hepatoprotective activity and anti-inflammatory activity.

Unraveling the effects of prenatal anesthesia on neurodevelopment: A review of current evidence and future directions.

Human brain development is a complex, multi-stage, and sensitive process, especially during the fetal stage. Animal studies over the last two decades have highlighted the potential risks of anesthetics to the developing brain, impacting its structure and function. This has raised concerns regarding the safety of anesthesia during pregnancy and its influence on fetal brain development, garnering significant attention from the anesthesiology community.

Sex-dimorphic functions of orexin in neuropsychiatric disorders.

The orexin system regulates a variety of physiological functions, including the sleep-wake cycle, addiction, foraging behavior, stress and cognitive functioning. Orexin levels in central and peripheral are related to the pathogenesis of many diseases, most notably the narcolepsy, eating disorders, stress-related psychiatric disorders, and neurodegenerative diseases. Recently, it has been reported that the orexin system is distinctly sexually dimorphic, and is strongly associated with neuropsychiatric disorders.

Synthesis and Biological Activities of C1-Substituted Acylhydrazone -Carboline Analogues as Antifungal Candidates.

In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone -carboline analogues - and - for their effectiveness against , , , and . Their compositions were analyzed using different spectral techniques, such as H/C NMR and HRMS, with the structure of being additionally confirmed through X-ray diffraction. The antifungal evaluation showed that, among all the target -carboline analogues, compounds and exhibited more promising and broad-spectrum antifungal activity than the commercial pesticide hymexazol.

The impact of hydrogen fuel cell heavy-duty trucks purchase subsidies on air quality.

The pollutant emissions of diesel-powered heavy-duty trucks (HDTs) seriously damage the air quality. The promotion of hydrogen fuel cell HDTs through purchase subsidy policy to reduce emissions has become an important approach to control air pollution. This study focuses on the impact of hydrogen fuel cell HDT purchase subsidies on air quality in the context of China, covering the panel data of 31 Chinese cities from 2014 to 2021 and applying a two-way fixed effects model to analyze the contribution of purchase subsidies and hydrogen refueling station construction subsidies to air quality.

Exploiting cell death and tumor immunity in cancer therapy: challenges and future directions.

Cancer remains a significant global challenge, with escalating incidence rates and a substantial burden on healthcare systems worldwide. Herein, we present an in-depth exploration of the intricate interplay between cancer cell death pathways and tumor immunity within the tumor microenvironment (TME). We begin by elucidating the epidemiological landscape of cancer, highlighting its pervasive impact on premature mortality and the pronounced burden in regions such as Asia and Africa.

A Calcium-Dependent Protein Kinase Regulates the Defense Response in .

Citrus Huanglongbing (HLB), which is caused by ' Liberibacter asiaticus' (CLas), is one of the most destructive citrus diseases worldwide, and defense-related gene resources remain largely unexplored. Calcium signaling plays an important role in diverse biological processes. In plants, a few calcium-dependent protein kinases (CDPKs/CPKs) have been shown to contribute to defense against pathogenic microbes.

Janus Membranes with Asymmetric Superwettability for High-Performance and Long-Term On-Demand Oil/Water Emulsion Separation.

Current single-function superwettable materials are typically designed for either oil removal or water removal and are constrained by oil density, limiting their widespread applications. Janus membranes with opposite wettability on their two surfaces have recently emerged and present attractive opportunities for on-demand oil/water emulsion separation. Here, a combination strategy is introduced to prepare a Janus membrane with asymmetric superwettability for switchable oil/water emulsion separation.

Adherence to Reporting Guidelines in Major Otolaryngology Publications.

The aim of this study is to determine the adherence rate to reporting guidelines in published otolaryngology research. We performed an evidence-based review of all original clinical research published in 2021 in five otolaryngology journals for adherence to the appropriate guideline for the study type by evaluating whether the corresponding reporting guideline was mentioned in the body of the published manuscript. There were 1140 original research articles included in this study.

Super-resolution reconstruction of underwater polarized images with a fused attention mechanism.

The polarization imaging technique leverages the disparity between target and background polarization information to mitigate the impact of backward scattered light, thereby enhancing image quality. However, the imaging model of this method exhibits limitations in extracting inter-image features, resulting in less-than-optimal outcomes in turbid underwater environments. In recent years, machine learning methodologies, particularly neural networks, have gained traction.

[DNA barcode screening, identification of germplasm resources, and analysis of genetic diversity of Anemarrhena asphodeloides].

Anemarrhena asphodeloides is a common medicinal material used in clinical prescriptions and Chinese patent medicine. In this study, the Illumina platform was used to obtain the chloroplast genome sequences of seven kinds of A. asphodeloides from different areas.

miR-30c-5p Protects from Brain Injury After Cerebral Aneurysmal Subarachnoid Hemorrhage Through the ATG5/ATG12 Pathway.

Objective: To assess the role of miR-30c-5p in subarachnoid hemorrhage (SAH) and its possible mechanism.

Methods: We established a SAH model by injecting fresh arterial non-heparinized blood into the anterior cistern of the optic chiasm of healthy Sprague-Dawley rats. Next, we treated the rats with a miR-30c-5p inhibitor or miR-30c-5p mimics.

3-Amide-β-carbolines block the cell cycle by targeting CDK2 and DNA in tumor cells potentially as anti-mitotic agents.

β-Carboline alkaloids are natural and synthetic products with outstanding antitumor activity. C substituted and dimerized β-carbolines exert excellent antitumor activity. In the present research, 37 β-carboline derivatives were synthesized and characterized.

Economic Evaluation of Pediatric Tracheostomy: A Cost of Illness Analysis.

Objective: This study aimed to determine the direct costs of pediatric tracheostomy care within a health care system.

Study Design: Prospective analysis.

Setting: Academic children's hospital.

Association of carotid wall shear stress measured by vector flow mapping technique with ba-PWV: a pilot study.

Objective: Arterial stiffness is an important tissue biomarker of the progression of atherosclerotic diseases. Brachial-ankle pulse wave velocity (ba-PWV) is a gold standard of arterial stiffness measurement widely used in Asia. Changes in vascular wall shear stress (WSS) lead to artery wall remodeling, which could give rise to an increase in arterial stiffness.

Inhibition of quorum sensing serves as an effective strategy to mitigate the risks of human bacterial pathogens in soil.

The coexistence of antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and virulence factor genes (VFGs) in human bacterial pathogens (HBPs) increases their risks to ecological security and human health and no effective strategy is available. Herein, we demonstrated two typical quorum sensing (QS) interfering agents, 4-nitropyridine-N-oxide (4-NPO, a QS inhibitor) and Acylase Ⅰ (a quorum quenching (QQ) enzyme), effectively decreased the abundance of HBPs by 48.30% and 72.

Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from var. .

The glucose transporter 1 (GLUT1) protein is involved in the basal-level absorption of glucose in tumor cells. Inhibiting GLUT1 decreases tumor cell proliferation and induces tumor cell damage. Natural GLUT1 inhibitors have been studied only to a small extent, and the structures of known natural GLUT1 inhibitors are limited to a few classes of natural products.