Publications by authors named "Jinghan Bu"
Article Synopsis
- Researchers developed a new method for breaking and reforming C-P bonds in organophosphine compounds, using palladium as a catalyst.
- The reaction efficiently targets the C(sp)-P(V) bond in α-aminophosphonates and can easily incorporate various halides for functionalization.
- The process is effective for synthesizing diverse organophosphine molecules at a larger scale, supported by mechanistic studies.
In this report, we present the dual activation models for transient directing group-directed and amino-self-directed Pd-catalyzed α-aminophosphonate side-chain C(sp)-H arylation. Both strategies showed facile, efficient, and single regioselectivity in the reaction between free α-aminophosphonates and aryl iodides. Furthermore, the modification of amino and late-stage functionalization of the C(sp)-P bond from products indicates potential applications for α-aminophosphonates.
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