Publications by authors named "Jingguang Fan"
Analysis of serum metabolome of laborers exposure to welding fume.
Int Arch Occup Environ Health
September 2023
Objective: Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of great importance. The aim of this study was to screen serum differential metabolites of welding fume exposure based on UPLC-QTOF-MS/MS.
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- * A new method for detecting protein-bound α-amanitin was developed, which involves trypsin hydrolysis and conventional liquid chromatography-mass spectrometry (LC‒MS) analysis.
- * This method extended the detection window for protein-bound α-amanitin to 10 days and achieved a detection rate of 53.33%, significantly better than the 0-4 hour window for free α-amanitin.
Approximately 70-90% of mushroom poisoning deaths are caused by α-amanitin-induced liver injury resulting from RNA polymerase II (RNAP II) inhibition. Liver regeneration ability may contribute greatly to individual survival after α-amanitin poisoning. However, it is unclear what cellular pathways are activated to stimulate regeneration.
View Article and Find Full Text PDFBackground: Little is known about the prevalence of latent tuberculosis infection (LTBI) among coal workers' pneumoconiosis (CWP) patients. To estimate the prevalence of LTBI and identify its associated risk factors among CWP patients.
Methods: A cross-sectional study was conducted to assess the prevalence of LTBI.
[Inhibitory mechanisms of three compounds for chrysotile-induced biological activities].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
October 2008
Objective: To study the effects of aluminum citrate (AC), rare earth compounds (REC) and sodium selenite (SS) on the surface elements of chrysotile fibers and the inhibitory mechanisms of three compounds for chrysotile-induced biological activities.
Methods: After being soaked in 250, 500 and 1000 microg/ml aluminum citrate solutions, 125, 250, 500 and 1000 microg/ml mixed rare earths solutions or 125, 250, 500 and 1000 microg/ml sodium selenite solutions for 10 min or 1 hour, the fabrication and the levels of surface elements of chrysotile fibers were determined.
Results: Aluminum citrate, mixed rare earths or sodium selenite all could be adsorbed by chrysotile fibers.