Chiral iodine-catalyzed asymmetric oxyamination of unactivated olefins.

In this paper, chiral aryl iodides were used for the first time to catalyze the formation of C-O and C-N bonds of inactive olefins to obtain optically active aminolactone derivatives. The reaction is compatible with various substituted alkenyl carboxylic acid substrates. This method usually shows high activity and enantioselectivity, with a yield of up to 83% and an ee of up to 99%.

Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway.

The newly identified estrogen receptor, G protein-coupled receptor 30 (GPR30), is prevalent in the brain and has been shown to provide significant neuroprotection. Recent studies have linked ferroptosis, a newly characterized form of programmed cell death, closely with cerebral ischemia-reperfusion injury (CIRI), highlighting it as a major contributing factor. Consequently, our research aimed to explore the potential of GPR30 targeting in controlling neuronal ferroptosis and lessening CIRI impacts.

Measurement and evaluation of agricultural technological innovation efficiency in the Yellow River Basin of China under water resource constraints.

Improving the efficiency of agricultural technology innovation is an inevitable requirement for ecological protection and sustainable agricultural development in the Yellow River Basin. Under the background of prominent water resources constraints in the Yellow River Basin, the actual level and regional differences of agricultural technology innovation efficiency in the basin are analyzed, which will provide theoretical basis and data reference for the development plan of agricultural modernization in the Yellow River Basin. The construction of evaluation index system and the choice of method are the main factors that affect the measurement results.

Identifying Qingkailing ingredients-dependent mesenchymal-epithelial transition factor-axiation "π" structuring module with angiogenesis and neurogenesis effects.

Objective: To explore the functional role of the drug-dependent mesenchymal-epithelial transition (Met)-axiation "π" structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ischemia.

Methods: We used a Glutathione S-transferase (GST)-pull down assay, isothermal titration calorimetry assay, and other related methods to identify the relationships among Met, inositol polyphosphate phosphatase like 1 (Inppl1), and death associated protein kinase 3 (Dapk3) in this allosteric module. The biological effects of the modules of neurons generation composed of Met, Inppl1, and Dapk3 were measured through Western blot, apoptosis analysis, and double immunofluorescence labeling.

Spatial difference analysis and dynamic evolution prediction of urban industrial integrated water use efficiency in China.

Comprehensive quantitative assessment of China's urban industrial water use efficiency is effectively promote the green industrial development important steps in order to realize the overall development of high quality. Between 2009 and 2021, 290 in China based on ground level above the panel data of the city, this paper conducts research based on two principles of efficiency improvement and four models of efficiency analysis. The results show that: First, from the perspective of spatial differences, the integrated water use efficiency of urban industry in China presents a slow and uneven upward trend of "low in the east and high in the west, high in the middle and low in the north and south".

Photoinduced Borylation of the Inert C(sp)-O Bond of Alkyl Heteroaryl Ethers.

A photoinduced reductive C-O borylation of alkyl heteroaryl ethers with very negative reduction potential in the presence of 4-dimethylaminopyridine (DMAP) and bis(catecholato)diborane(Bcat) was developed. Despite the high reducing power, various substrates with liable functional groups were well-tolerated as well as ethers derived from natural products and medicinal-relevant compounds. Mechanistic investigation implied that an intra-single electron transfer process in an electron donor-acceptor complex formed from ethers with the adduct of Bcat and DMAP should be involved.

The Effects of Angiosome Morphology on Choke Vessels and Flap Necrosis in a Rat Multiterritory Perforator Flap.

Background: Although the angiosome concept has been proposed for a long time, very few studies have been done on its morphology. Our study investigated the effects of angiosome morphology on choke vessels and flap necrosis in a rat multiterritory perforator flap.

Methods: Seventy-two male Sprague-Dawley rats were randomly divided into 3 groups (n = 24/group).

Local atomic structure studies of ZrCuAl alloy around T.

As a result of examining the structure of ZrCuAl alloy around the glass transition temperature (T) using the classical molecular dynamics simulations, it was proven that the atomic bonds in the interconnecting zones (i-zones) became loose with the small amount of energy absorption, and it became free volumes easily when the temperature approached T. Instead of i-zones, when clusters were largely separated by free volume networks, the solid amorphous structure was converted into supercooled liquid state, resulting in a sharp strength reduce and the great plasticity change from a limited plastic deformation to superplasticity.

Cytotoxicity of 4 Wild Mushrooms in a Case of Yunnan Sudden Unexplained Death.

Objectives: To explore the cytotoxicity of four wild mushrooms involved in a case of Yunnan sudden unexplained death (YNSUD), to provide the experimental basis for prevention and treatment of YNSUD.

Methods: Four kinds of wild mushrooms that were eaten by family members in this YNSUD incident were collected and identified by expert identification and gene sequencing. Raw extracts from four wild mushrooms were extracted by ultrasonic extraction to intervene HEK293 cells, and the mushrooms with obvious cytotoxicity were screened by Cell Counting Kit-8 (CCK-8).

Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles.

Three series of podophyllotoxin derivatives with various nitrogen-containing heterocycles were designed and synthesized. The antitumor activity of these podophyllotoxin derivatives was evaluated against a panel of human tumor cell lines. The results showed that podophyllotoxin-imidazolium salts and podophyllotoxin-1,2,4-triazolium salts exhibited excellent cytotoxic activity.

Radical C(sp)-S Coupling for the Synthesis of α-Amino Sulfides.

A unique transition-metal-free radical thiolation of 2-azaallyl anions has been developed. Easily accessible thiosulfonates and 2-azaallyls undergo the tandem process of single-electron transfer and radical-radical coupling to construct C(sp)-S bonds. This robust protocol enables a mild and chemoselective coupling between 2-azaallyl anions and thiosulfonates to access α-amino sulfides in 50-92% yields (25 examples).

Characteristics, health risks, and premature mortality attributable to ambient air pollutants in four functional areas in Jining, China.

Air pollution is one of the leading causes for global deaths and understanding pollutant emission sources is key to successful mitigation policies. Air quality data in the urban, suburban, industrial, and rural areas (UA, SA, IA, and RA) of Jining, Shandong Province in China, were collected to compare the characteristics and associated health risks. The average concentrations of PM, PM, SO, NO, and CO show differences of -3.

Pummerer-like Rearrangement Induced Cascade Reactions: Synthesis of Highly Functionalized Imidazoles.

Imidazoles are among the most important pharmacophores in medicinal chemistry. Herein we report a tandem protocol for the synthesis of highly substituted imidazoles through Pummerer-like rearrangement induced cascade reactions including two carbon-nitrogen bond formations, and concomitant aromatization under mild reaction conditions. This procedure gives imidazole derivatives bearing numerous functional groups and could be used for modifying natural products as well as pharmaceuticals.

Enantioselective Total Synthesis of Spirotryprostatin A.

In this paper, we disclosed a novel enantioselective total synthesis of spirotryprostatin A () in 15 steps with a 7.4% total yield from commercially available 2-iodo-5-methoxyaniline and γ-butyrolactone. The key step features of this synthesis include the copper-catalyzed cascade reaction of -iodoaniline derivatives with alkynone to introduce the quaternary carbon stereocenter and an aza-Michael tandem reaction to construct the spiro[pyrrolidine-3,3'-oxindole] moiety.

Design of digital economy consumer psychology prediction model based on canopy clustering algorithm.

With the continuous improvement of the level of science and technology, the popularization of the Internet and the development of applications, online consumption has become a major force in personal consumption. As a result, digital consumption is born, and digital consumption is not only reflected in transaction consumption at the monetary level. Like some intangible services similar to the use of dating software, it can also become digital consumption.

The Propulsion Path of Synergy and Linkage Based on Artificial Intelligence and Digital Economy.

From conception to birth, artificial intelligence inherited the power of human reproduction, such as creativity, self-improvement and language use, etc. These abilities cannot be exercised in other places. The purpose of this paper is to explore the path of collaborative promotion based on artificial intelligence and digital economy.

Regional Private Financing Risk Index Model Based on Private Financing Big Data.

With the rapid development of China's economy in recent decades, and the decentralization of the country's economic regulation and legal support, private financing has developed rapidly due to its simple, flexible and unique advantages. Some SMEs can solve it to some extent through private financing. The company's own financing issues have also helped the local financial market's effectiveness.

Integrated Design of Financial Self-Service Terminal Based on Artificial Intelligence Voice Interaction.

Integrated design of financial self-service terminal based on artificial intelligence voice interaction with the rapid development of science and technology, artificial intelligence technology is deepening in the field of intelligence and automation. The financial industry is the lifeblood of a country's economy, with great growth potential and high growth rate. The integrated design of intelligent financial self-service terminal has become an important topic in the field of rapid development of social economy and science and technology.

Synthesis of 1-pyrroline derivatives cyclization of terminal alkynes with 2-azaallyls.

An efficient transition-metal-free cyclization reaction to prepare 1-pyrroline derivatives bearing various functional groups is described. In this method, a simple combination of a base and a solvent allows the cyclization reaction of terminal alkynes and 2-azaallyls to be carried out efficiently under mild and metal-free conditions. This cyclization reaction will provide an efficient method for the synthesis of medicinally relevant polysubstituted and multifunctionalized pyrrolines.

Supply chain security evaluation model and index system based on a 5G information system.

Currently, the supply chain management model has been widely adopted worldwide. Internationally renowned companies such as IBM and Walmart have made significant achievements in supply chain management and have played a greater role in promoting the growth of their interests. However, while they are enjoying their own interests, they are also facing various risks in the supply chain.

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer.

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and -butanesulfinamides.

Synthesis of Highly Functionalized Pyridines: A Metal-Free Cascade Process.

Herein, we report a new process for the synthesis of highly functionalized pyridines based on a tandem Pummerer-type rearrangement, aza-Prins cyclization, and elimination-induced aromatization. This formal [5+1] cyclization provides pyridines in good yields with easily accessible starting materials. The synthetic potential of our new method is further demonstrated in the modification of the frameworks of BINOL and some natural products.

Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines.

Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation.

Total Synthesis of Dactylicapnosines A and B.

Dactylicapnosines A and B, two natural products from , exhibited potent anti-inflammatory and analgesic activities both in vitro and in vivo. In this paper, we report our second-generation synthesis of dactylicapnosine A and the first total synthesis of dactylicapnosine B. Our synthetic route features acid-induced isomerization of -quinone (), Co-mediated regioselective ring contraction of -quinone (), and oxidative methoxylation of enone ().