This study investigated the effects of lactic acid esters of monoglycerides (LACTEM) on the fat crystallization, interfacial properties, and their relationship with the qualities of whipped cream. LACTEM promoted the formation of moderate size fat crystals at low concentrations (≤0.10 wt%).
View Article and Find Full Text PDFStyphnolobium japonicum (L.) Schott, is an ornamental species of Leguminosae, widely planted as a roadside tree in north regions of China (Kite et al. 2007).
View Article and Find Full Text PDFTiO-SiO composite oxides with different Ti/Si ratios were synthesized by [sol-gel] method. The highest catalytic activity was obtained over T+S-0.75 loaded with 5 % CoO by in-situ method using cobalt stearate as precursor.
View Article and Find Full Text PDFColor vision deficiency (CVD) affects a significant portion of the population, yet its impact is often overlooked in medical education, especially in visually demanding specialties like dermatology, pathology, and radiology. In this study, we investigated the potential of ChatGPT to comprehend CVD-simulated images in image-based diagnostic tasks. Notably, the model successfully adapted its diagnostic reasoning to match CVD-modified color perception while preserving high prediction accuracy.
View Article and Find Full Text PDFCurr Treat Options Oncol
November 2024
Bone metastasis, a frequent and detrimental complication of advanced cancers, often triggers bone deterioration events that severely compromise patient quality of life and prognosis. The past few years have witnessed the emergence and continuous advancements in immunotherapy, ushering in innovative therapeutic prospects for bone metastasis. These advancements include not only the use of immune checkpoint inhibitors (ICIs), both as standalone and combined treatments, but also the investigation of novel targets within immune cells residing in bone metastases.
View Article and Find Full Text PDFThe year 2023 marked a significant surge in the exploration of applying large language model chatbots, notably Chat Generative Pre-trained Transformer (ChatGPT), across various disciplines. We surveyed the application of ChatGPT in bioinformatics and biomedical informatics throughout the year, covering omics, genetics, biomedical text mining, drug discovery, biomedical image understanding, bioinformatics programming, and bioinformatics education. Our survey delineates the current strengths and limitations of this chatbot in bioinformatics and offers insights into potential avenues for future developments.
View Article and Find Full Text PDFThe use of biomass as a carbon source to support metal oxides has significant advantages in environmental protection and reducing the cost of the catalyst. The critical point lies on the development of highly active and recyclable catalysts. In this study, sugar was used as a carbon source, and cobalt oxide was loaded an method and an impregnation method to prepare the catalyst, respectively.
View Article and Find Full Text PDFBackground: Policy makers and researchers are tasked with exploring ways to strengthen primary health care (PHC) to address the growing burden of non-communicable diseases (NCDs). This study aims to use a co-design approach (i.e.
View Article and Find Full Text PDFObjective: Paraspinal muscle segmentation and reconstruction from MR images are critical to implement quantitative assessment of chronic and recurrent low back pains. Due to unclear muscle boundaries and shape variations, current segmentation methods demonstrate suboptimal performance with insufficient training samples. This work proposes a novel approach to modeling and inferring muscle shapes that enhances segmentation accuracy and efficiency with few training data.
View Article and Find Full Text PDFEmerging studies underscore the promising capabilities of large language model-based chatbots in conducting basic bioinformatics data analyses. The recent feature of accepting image inputs by ChatGPT, also known as GPT-4V(ision), motivated us to explore its efficacy in deciphering bioinformatics scientific figures. Our evaluation with examples in cancer research, including sequencing data analysis, multimodal network-based drug repositioning, and tumor clonal evolution, revealed that ChatGPT can proficiently explain different plot types and apply biological knowledge to enrich interpretations.
View Article and Find Full Text PDFThe year 2023 marked a significant surge in the exploration of applying large language model (LLM) chatbots, notably ChatGPT, across various disciplines. We surveyed the applications of ChatGPT in bioinformatics and biomedical informatics throughout the year, covering omics, genetics, biomedical text mining, drug discovery, biomedical image understanding, bioinformatics programming, and bioinformatics education. Our survey delineates the current strengths and limitations of this chatbot in bioinformatics and offers insights into potential avenues for future developments.
View Article and Find Full Text PDFBiomimetics (Basel)
March 2024
Biological fish exhibit a remarkably broad-spectrum visual perception capability. Inspired by the eye arrangement of biological fish, we design a fish-like binocular vision system, thereby endowing underwater bionic robots with an exceptionally broad visual perception capacity. Firstly, based on the design principles of binocular visual field overlap and tangency to streamlined shapes, a fish-like vision system is developed for underwater robots, enabling wide-field underwater perception without a waterproof cover.
View Article and Find Full Text PDFFace learning has important critical periods during development. However, the computational mechanisms of critical periods remain unknown. Here, we conducted a series of experiments and showed that, similar to humans, deep artificial neural networks exhibited critical periods during which a stimulus deficit could impair the development of face learning.
View Article and Find Full Text PDFTo expand the market capacity of p-diethylbenzene (PDEB), core-shell zeolite (TS-1@MCM-48) is designed as a catalyst for PDEB oxidation. TS-1@MCM-48 catalyst is synthesized by in-situ crystallization method and characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), N adsorption-desorption, in-situ electron paramagnetic resonance (EPR) and Si nuclear magnetic resonance (Si MAS-NMR). Oxidation of PDEB by HO was investigated systematically in liquid phase.
View Article and Find Full Text PDFRecognizing familiar faces and learning new faces play an important role in social cognition. However, the underlying neural computational mechanisms remain unclear. Here, we record from single neurons in the human amygdala and hippocampus and find a greater neuronal representational distance between pairs of familiar faces than unfamiliar faces, suggesting that neural representations for familiar faces are more distinct.
View Article and Find Full Text PDFEmerging studies underscore the promising capabilities of large language model-based chatbots in conducting fundamental bioinformatics data analyses. The recent feature of accepting image-inputs by ChatGPT motivated us to explore its efficacy in deciphering bioinformatics illustrations. Our evaluation with examples in cancer research, including sequencing data analysis, multimodal network-based drug repositioning, and tumor clonal evolution, revealed that ChatGPT can proficiently explain different plot types and apply biological knowledge to enrich interpretations.
View Article and Find Full Text PDFBackground: The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which are affected by transmembrane proteins localized in the ER membrane. One such protein, transmembrane protein 147 (TMEM147), has recently been implicated for its role in hepatocellular carcinoma (HCC) tumorigenesis; however, the mechanisms remain unclear. We investigated the role of TMEM147 in HCC and the underlying mechanisms.
View Article and Find Full Text PDFThe sensitivity and accuracy of electrochemiluminescence (ECL) sensors for detecting small-molecule pollutants in environmental water are affected not only by nonspecific adsorption of proteins and other molecules but also by bacterial interference. Therefore, there is an urgent need to develop an ECL sensor with antifouling and antibacterial functions for water environment monitoring. Herein, a highly efficient antifouling sensing interface (PSBMA@SiO-MXene) based on zwitterionic sulfobetaine methacrylate (SBMA) antifouling nanospheres (NPs) and two-dimensional MXene nanosheets was designed for the sensitive detection of oxytetracycline (OTC), an antibiotic small-molecule pollutant.
View Article and Find Full Text PDFThe misuse of antibiotics leading to bacterial multidrug resistance is responsible for severe infectious diseases and a significant cause of mortality worldwide, resulting in numerous human disasters. Photodynamic antibacterial therapy (PDAT) is a promising strategy against multiantibiotic-resistant bacteria, but its antibacterial activity is greatly limited by reduced glutathione (GSH) in bacteria. In this study, we constructed a nanoplatform through the formation of metal chelating complexes (FeP) between ferric and pyrophosphate ions, with subsequent adsorption of the photosensitizer ZnPc(COOH) (octa-carboxyl substituted zinc phthalocyanine) mediated by polylysine (PL) on the surface.
View Article and Find Full Text PDFRecently, rapid acquisition of bacterial resistance and consequent slow healing of infected wounds threaten human life and health. In this study, chitosan-based hydrogels and nanocomplexes ZnPc(COOH):PMB composed of photosensitizer ZnPc(COOH) and antibiotic polymyxin B (PMB) were integrated into a thermosensitive antibacterial platform ZnPc(COOH):PMB@gel. Interestingly, fluorescence and reactive oxygen species (ROS) of ZnPc(COOH):PMB@gel can be triggered by E.
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