Publications by authors named "Jingai Bi"
Article Synopsis
- Adenoviral DNA is frequently found in tonsil specimens from children who undergo adenotonsillectomy, suggesting the virus remains in a latent state.
- In a study of 81 patients, 85.2% of the tonsil samples tested positive for human adenovirus (HAdV), revealing a link between specific tonsil microbiota profiles and the presence of the virus.
- The research indicates that certain bacteria and short-chain fatty acids present in the tonsils may contribute to the reactivation of HAdV, potentially leading to respiratory infections, particularly in children and organ transplant recipients.
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the digestive tract. The treatment commonly includes anti-inflammatory agents like 5-aminosalicylic acid or corticosteroids or biologics for people with UC who are no longer responding to corticosteroids. The radices of Paeonia lactiflora Pall.
View Article and Find Full Text PDFSalsalate, an ester formed by 2 salicylic acid molecules, has beneficial effect against metabolic disorders in clinical trials and in animal studies. This study focused on the mechanistic aspects of salsalate activity against non-alcoholic fatty liver disease (NAFLD). Using high-fat diet (HFD) fed mice, we showed that salsalate treatment decreased body-weight gains, reduced white adipose tissue mass and improved glycaemic control.
View Article and Find Full Text PDFArticle Synopsis
- - Mutations in the p53 gene in cancer cells not only disrupt its ability to prevent cell growth but can also drive cancer development through abnormal activity.
- - A study found that the compound NA20 can inhibit the harmful effects of mutant p53 in gastric cancer cells by blocking the p53-EGFR signaling pathway, contributing to reduced tumor growth.
- - NA20 works by binding to DNA and p53, activating the p21 protein, and preventing the signaling that leads to cell division, ultimately causing cancer cell death both in lab experiments and in living organisms.
Ethnopharmacological Relevance: Dang-Gui-Shao-Yao-San () and Gui-Zhi-Fu-Ling-Tang () and among the herbal medicines commonly used to treat primary dysmenorrhea with proven record of effectiveness.
Aim Of This Study: This study aims to assess the effectiveness of herbal medicines on relieving primary dysmenorrhea in a murine model and to delineate a plausible mechanism.
Materials And Methods: Herbal medicines in the form of pills (Wan) or capsules, including Gui-Zhi-Fu-Ling capsule, Gui-Zhi-Fu-Ling-Wan, Jia-Wei-Xiao-Yao-Wan, and Shao-Fu-Zhu-Yu capsule were purchased from local drug stores in Nanjing.