Exo70 Promotes the Invasion of Pancreatic Cancer Cells via the Regulation of Exosomes.

Pancreatic cancer (PC) is an aggressive and fatal malignant tumor, and exosomes have been reported to be closely related to PC invasion and metastasis. Here we found that Exo70, a key subunit of the exocyst complex, promoted PC metastasis by regulating the secretion of tumor exosomes. Clinical sample studies showed that Exo70 was highly expressed in PC and negatively correlated with patients' survival.

Studies of the Efficacy of Low-Dose Apatinib Monotherapy as Third-Line Treatment in Patients with Metastatic Colorectal Cancer and Apatinib's Novel Anticancer Effect by Inhibiting Tumor-Derived Exosome Secretion.

Antiangiogenic therapy is an important treatment strategy for metastatic colorectal cancer (mCRC). We carried out a clinical study of low-dose apatinib (250 mg) monotherapy as a third-line treatment in patients with mCRC and assessed its efficacy and safety. It demonstrated that low-dose apatinib had comparable survival outcomes, significantly improved the patient quality of life, and caused tolerable adverse reactions.

Clinical research on restorations using CAD/CAM-fabricated monolithic zirconia endocrowns and post and core crowns after up to 5 years.

Objective: To assess the clinical status of monolithic zirconia CAD/CAM endocrowns and crowns on post and core buildups in endodontically treated molars after 5 years of clinical service.

Materials And Methods: A total of 670 patients who received restorations for excessive defects at Ansteel Group Hospital from 2012 to 2015 were selected and randomly divided into two groups: 334 patients in the endocrown group and 336 in the post and core crown group. All the treatments were performed using a digital CAD/CAM system.

ULK1 phosphorylates Exo70 to suppress breast cancer metastasis.

Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of the exocyst complex.

Clinical performance of CAD/CAM-fabricated monolithic zirconia endocrowns on molars with extensive coronal loss of substance.

Objective: To clinically evaluate computer-aided design/computer-aided manufacturing (CAD/CAM)-fabricated molar endocrowns after 6 months and 1, 2, and 3 years of clinical service.

Materials And Methods: 289 patients with 321 molars (267 patients with one endocrown, two patients with two endocrowns, and ten patients with three endocrowns) exhibiting extensive coronal loss of substance participated in the study. Endocrown preparations were scanned, and endocrowns designed and machined with the Cerec CAD/CAM system.

[Assessment of life quality of for patients after tongue reconstruction with radial forearm free flap, anterolateral thigh perforator flap or submental island flap].

Purpose: The aim of this study was to evaluate operation-related factors and quality of life (QOL) for patients after tongue reconstruction with radial forearm free flap (RFFF), anterolateral thigh perforator flap (ALT) or submental island flap (SIF).

Methods: Totally 59 patients, diagnosed as tongue carcinoma, received glossectomy and simultaneous reconstruction with free flaps including RFFF, ALT or SIF in the Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, China Medical University from October 2004 to October 2014. All patients were followed up for 6 months and completed the University of Washington Quality of Life scale Version 4 questionnaires.