Sialic Acid-Modified nanomedicines modulate neutrophils for dual therapy of cancer and sepsis: Addressing neglected sepsis comorbidities during cancer treatment.

Advanced cancer patients face a high risk of sepsis due to immune suppression and infection susceptibility. To tackle this challenge, we developed an innovative animal model that simulates the clinical scenario of late-stage cancer complicated by sepsis and designed a sialic acid (SA)-modified paclitaxel (PTX) liposome (PTX-SAL). This formulation specifically targets overactivated peripheral blood neutrophils (PBNs) by binding to L-selectin on their surface.

Body shape concerns and behavioral intentions on eating disorders: a cross-sectional study of Chinese female university students using an extended theory of reasoned action model.

Background: Weight and body shape concerns have become increasingly common among adolescents. Chinese university students show a high risk of eating disorder behaviors. This study aims to analyze the moderating effect of BMI on the relationships between body shape, attitudes, subjective norms, and eating disorder behavioral intentions among Chinese female university students using the Theory of Reasoned Action (TRA) model.

Overexpression of SikPsaF can increase the biomass of Broussonetia papyrifera by improving its photosynthetic efficiency and cold tolerance.

Photosynthesis is essential for the accumulation of organic compounds in plant leaves. Study of photosynthesis in the leaves of Broussonetia papyrifera is crucial for enhancing its biomass production, growth, and development. Here, we cloned the SikPsaF gene associated with photosynthesis from Saussurea involucrata and constructed a vector that was introduced into B.

Investigating the common genetic architecture and causality of metabolic disorders with neurodegenerative diseases.

Background: The co-occurrence of metabolic dysfunction and neurodegenerative diseases suggests a genetic link, yet the shared genetic architecture and causality remain unclear. We aimed to comprehensively characterise these genetic relationships.

Methods: We investigated genetic correlations among four neurodegenerative diseases and seven metabolic dysfunctions, followed by bidirectional Mendelian randomisation (MR) to assess potential causal relationships.

Including Health System Capacities into the Assessment Framework of a Temperature-Resilience Health System.

Introduction: This study includes health system capacities into the assessment framework of a temperature-resilience health system while accounting for system interactions.

Methods: In accordance with the guidelines provided by the World Health Organization, the conceptual framework of a climate-resilient health system has been adopted. The International Health Regulations are utilized to assess the health system capacities in 171 countries from year 2011 to 2019.

CT-based whole lung radiomics nomogram to identify middle-aged and elderly COVID-19 patients at high risk of progressing to critical disease.

Background: COVID-19 remains widespread and poses a threat to people's physical and mental health, especially middle-aged and elderly individuals. Early identification of COVID-19 patients at high risk of progressing to critical disease helps improve overall patient outcomes and healthcare efficiency.

Purpose: To develop a radiomics nomogram to predict the risk of newly admitted middle-aged and elderly COVID-19 patients progressing to critical disease.

Optical trapping using quasi-bound states in the continuum of photonic crystal slab.

This paper explores efficient and stable optical trapping using quasi-bound states in the continuum (quasi-BICs) in photonic crystal slabs. By breaking inversion symmetry by transforming square holes into isosceles trapezoidal holes, we create quasi-BICs with finite quality factors. Calculations show that optical forces at enhanced electric field locations effectively trap particles, with significant potential wells at these sites.

Ginkgo biloba extract safety: Insights from a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events.

Ethnopharmacological Relevance: A traditional Chinese medicine extracted from the Ginkgophyta, Ginkgo biloba is commonly used to treat cardiac cerebral disease all over the world. Limited data exist regarding adverse drug reactions associated with Ginkgo biloba extract post-marketing.

Aim Of The Study: Currently, the drug safety profile of Ginkgo biloba extract is assessed using a substantial volume of case safety reports within the FDA Adverse Event Reporting System (FAERS) database.

Utilization of traditional Chinese medicine in the management of cutaneous ulceration induced by cervical lymph node metastasis in tonsillar carcinoma: A case report.

Objective: Cutaneous ulcers induced by metastasis present a challenging clinical issue, often resistant to conventional dressing change interventions. In this case, we demonstrates the efficacy of Traditional Chinese Medicine in managing ruptured tumors.

Case Presentation: We present a case study of a 40-year-old Chinese male patient diagnosed with advanced tonsillar squamous cell carcinoma with cervical lymph node metastasis and cutaneous ulceration.

Nutritional status and neurodevelopmental levels in infants at high risk of cerebral palsy.

Importance: Nutrition is associated with neurodevelopment. Infants at high risk of cerebral palsy (CP) usually suffer from undernutrition, yet the relationship between nutritional status and neurodevelopmental levels is unclear.

Objective: To describe the nutritional status characteristics of infants at high risk of CP, and to explore the relationship between neurodevelopmental levels and nutritional status.

Direct detection of endogenous Gαi activity in cells with a sensitive conformational biosensor.

Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is not only a mechanism broadly used by eukaryotes to transduce signals across the plasma membrane, but also the target for a large fraction of clinical drugs. However, approaches typically used to assess this signaling mechanism by directly measuring G-protein activity, like optical biosensors, suffer from limitations. On one hand, many of these biosensors require expression of exogenous GPCRs and/or G-proteins, compromising readout fidelity.

Novel coumarin-based ratiometric bifunctional fluorescent probe mimicking a set-reset memorized device.

A novel coumarin-based fluorescent sensor CHE, incorporating 2-hydrazinylbenzothiazole and coumarin aldehyde, has been developed that demonstrated a preferential detection of Hg and Ag in presence of interferences. Compared to previously prevalent intensity-based fluorescent probes, CHE exhibited a ratiometric fluorescence response to Hg and Ag, and further accurately differentiated Hg and Ag  using the differential extractive ability of EDTA when interacting with ion-CHE complexes. Sensing mechanism was investigated and elucidated.

The biosynthesis of asiaticoside and madecassoside reveals tandem duplication-directed evolution of glycoside glycosyltransferases in the Apiales.

Certain plant species within the Apiales order accumulate triterpenoid saponins that feature a distinctive glucose-glucose-rhamnose (G-G-R) sugar chain attached at the C-28 position of the pentacyclic triterpene skeleton. Until recently, the genomic basis underlying the biosynthesis and evolution of this sugar chain has remained elusive. In this study, we identified two novel glycoside glycosyltransferases (GGTs) that can sequentially install the sugar chain's second D-glucose and third L-rhamnose during the biosynthesis of asiaticoside and madecassoside, two representative G-G-R sugar chain-containing triterpenoid saponins produced by Centella asiatica.

Clinical Effect Analysis of Fire-needle Acupuncture at Neiyingxiang Treating Persistent Allergic Rhinitis.

Objectives: We conducted the first trial to evaluate the effect that fire-needle acupuncture at Neiyingxiang (ExHN 9) in patients with moderate to severe persistent AR.

Methods: This was a randomized, single-center, sham, and placebo-controlled rial. Patients were kept blinded to their group assignment.

Turn-on mode probe based on the sustainable xanthohumol extract for the efficient viscosity response in a liquid system.

Viscosity is a typical physical parameter and plays an important role in nutrient transferring, diffusion process regulating and safety warning. Aberrant mitochondrial viscosity is closely associated with an imbalance in a liquid system. Nevertheless, there is currently a lack of convenient and efficient tools for the mutation of viscosity detection at the molecular level.

The Relationship and Effects of Self-Esteem and Body Shape on Eating Disorder Behavior: A Cross-Sectional Survey of Chinese University Students.

Background: Eating disorders (EDs) have become a global public health concern among adolescents and young adults. However, Chinese university students exhibit a high prevalence of eating disorders. This study aims to investigate the effects of self-esteem (SE) and body shape (BS) on ED behaviors among Chinese university students.

Evaluation of Rhododendri Mollis Flos and its representative component as a potential analgesic.

Rhododendri Mollis Flos (R. mole Flos), the dried flowers of Rhododendron mole G. Don, have the ability to relieve pain, dispel wind and dampness, and dissolve blood stasis, but they are highly poisonous.

Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue.

Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway.

A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus .

A newly discovered trihydroxynaphthalenone derivative, epoxynaphthalenone () involving the condensation of ortho-hydroxyl groups into an epoxy structure, and a novel pyrone metabolite characterized as pyroneaceacid (), were extracted from , an endophytic fungus residing in . The structures of these compounds were elucidated through a comprehensive analysis of their NMR and HRESIMS data. The determination of absolute configurations was accomplished using electronic circular dichroism (ECD) calculations and CD spectra.