Effects of Probucol on plasma amyloid-β transport in patients with hyperlipidemia: a 12-week randomized, double-blind, placebo-controlled trial.

Background: Although dyslipidemia has been acknowledged as a risk factor for Alzheimer's disease (AD), the effects of lipid-lowering drugs on AD have not been determined. The primary pathophysiological hallmark of AD is the deposition of amyloid-β (Aβ) plaques in the brain. Plasma Aβ levels are influenced by the transport of Aβ from the central nervous system to the peripheral blood.

5-Aminolevulinic Acid (5-ALA)-Induced Drought Resistance in Maize Seedling Root at Physiological and Transcriptomic Levels.

Drought stress seriously affects the growth, development, yield, and quality of maize. This study aimed to investigate the effects of exogenous 5-ALA on root morphology and physiological changes in maize seedlings and to detect its regulatory network. The results showed that adding 25 mg/L 5-ALA accelerated root morphogenesis (root average diameter, main root length, total root length, and root surface area) and promoted dry matter accumulation and free radical removal.

Preparation of Functional Food with Enhanced Antioxidant Properties by Adding Polyphenol Honey.

To enhance the functionality of honey, particularly its antioxidant capacity, the incorporation of polyphenols (AMPs) is an effective approach. The preparation technology and antioxidant activity of AMP added to honey were studied. AMP was extracted with ethanol and its components were analyzed and then mixed evenly with honey in different addition amounts (0.

Phytochemical, pharmacological, pharmacokinetic and toxicological characteristics of : a review.

(ZSS) is the seeds of (Bunge) Hu ex H. F. Chou, which has the effects of nourishing heart and liver, tranquilizing heart and tranquilizing mind.

Human plasma inositol hexakisphosphate (InsP ) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1).

Inositol hexakisphosphate (InsP ), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP molecules are associated with magnesium. Calcium is the prevalent bivalent cation outside the cell and its association with InsP could lead to the formation of insoluble complexes.

Effect of black highland barley polysaccharides and low frequency-static magnetic field on casein-based coacervates: Formation, characterization, and probiotic encapsulation capacity.

To evaluate the combination effects of highland barley polysaccharides (HBP) and low-frequency static magnetic field (LF-SMF) treatment on the structure and properties of acid-induced casein (CS) coacervates, this study conducted a comprehensive investigation at various stages- before, during, and after coacervation-for the first time. Compared with native CS, adding HBP caused CS to denature owing to hydrophobic and electrostatic interactions, and LF-SMF treatment further promoted these changes. During the acidification (pH 7.

Stimulating the Potential of Zn Anodes to Operate in Low pH and Harsh Environments forHighly Sustainable Zn Batteries.

Compared to near-neutral electrolytes (pH=3-6), Zn||Mn batteries in acidic environments can achieve voltages up to ~2 V. However, high proton concentrations raise concerns about Zn anode stability. Current strategies for inhibiting hydrogen evolution corrosion (HEC) on the anode in Zn-based batteries mainly focus on the near-neutral electrolytes.

M1 polarization of hepatic macrophages in cows with subclinical ketosis is an important cause of liver injury.

Subclinical ketosis (SCK) is highly prevalent and easily overlooked, with insidious and slow progression of hepatic injury, often characterized by an imbalance in immune homeostasis. In nonruminants, macrophage polarization plays an important regulatory role in hepatic lipid accumulation, fibrosis and inflammatory processes. Thus, we aimed to investigate the status of hepatic macrophage polarization in SCK cows and to corroborate its association with liver injury and inflammation.

Temperature-dependent luminescent copper nanoclusters with noncovalent interactions for determination of β-galactosidase activity.

The synthesis of a novel bidentate ligand-protected copper nanocluster via a solid-state strategy is reported. Single-crystal X-ray diffraction analysis result reveals that the copper nanocluster features an octahedral core (Cu) coordinated by six ligands. Noncovalent interactions (C-Hπ and ππ) exist between the copper nanoclusters.

Polarization division multiplexing link using a high-speed lithium niobate automatic polarization demultiplexer.

We propose and experimentally demonstrate a polarization division multiplexing (PDM) link employing an integrated dual-polarization thin-film lithium niobate (TFLN) modulator and an on-chip automatic polarization demultiplexer. The tracking speed of an 80-Gb/s PDM link achieves a maximum of 600 rad/s with a bit error rate (BER) below 2.4 × 10.

Swine RNF5 positively regulates the antiviral activity of IFITM1 by mediating the degradation of ABHD16A.

Unlabelled: Interferon-inducible transmembrane (IFITM) proteins are broad-spectrum antiviral factors that confer cellular resistance to virus invasion. α/β-Hydrolase domain-containing 16A (ABHD16A) has recently been identified as a novel depalmitoylase that can inhibit the antiviral activity of IFITM proteins by catalyzing the depalmitoyl reaction; this pattern may be crucial for the host to avoid damage caused by excessive immune response. However, it remains largely elusive about how host cells regulate the activity of ABHD16A.

Efficacy and Molecular Mechanisms of Nystatin Against on Postharvest Table Grape.

The primary cause of postharvest loss in table grape fruit is attributed to gray mold, which is caused by . The present study confirmed the inhibitory effects of nystatin on the growth and development of , which led to a remarkable reduction in the severity of gray mold on table grape fruits. Furthermore, the application of nystatin disrupted the membrane permeability of , causing increased cellular leakage and cell death.

A Longitudinal Study of Loneliness Before the End of the COVID-19 Pandemic: Trajectories, Predictors, and Impact on Chinese Adolescent Mental Health.

Background: COVID-19 threatened global health, however little is known about the long-term courses of loneliness and their effect on mental health in adolescents. This study aimed to explore the trajectories of loneliness among adolescents in Taizhou, Zhejiang Province, China, during the last phase of the pandemic. We also aimed to identify risk factors in each loneliness course and the impact of loneliness on emotional problems, peer problems, hyperactivity and conduct problems.

Redox Oscillation-Driven Production of Reactive Oxygen Species from Black Carbon.

Wildfire and stubble burning release substantial amounts of black carbon (BC) into natural environments that experience frequent redox oscillations, such as wetlands and farmlands. Here, we report that redox oscillations can effectively drive ROS production from BC. Following sequential microbial reduction and air exposure, 6.

Interplay between Dynamic Phase and Geometric Phase Determines the Circular Dichroism and Helical Dichroism.

Understanding the interaction between light and chiral nanostructures is of fundamental importance, yet the principles governing chiral interactions have remained largely phenomenological. In this work, we present a chiral field-mode (FM) matching model to quantify the circular dichroism (CD) and helical dichroism (HD) of chiral plasmonic nanostructures interacting with beams of different spin-orbit states. The chiral FM matching model posits that among the inherent resonance modes within the nanostructure, the most efficiently excited mode is the one that matches the external field structure by possessing one more node along the vibration direction, with the field structure itself being determined by the interaction between the geometric phase and dynamic phase through a Doppler-like effect.

Oxidative and endoplasmic reticulum stress in diabetes-related hearing loss: Protective effects of thioredoxin.

Diabetes mellitus (DM) induces complex physiological changes in the inner ear environment. This study investigates the roles of oxidative stress (OS) and endoplasmic reticulum stress (ERS) in diabetes-related hearing loss (DRHL) and explores the potential of thioredoxin (Trx) in regulating OS, ERS, and apoptosis-related factors to mitigate the progression of hearing impairment. We conducted auditory and serological assessments in 63 patients with type 2 diabetes and 30 healthy controls.

Silica-coated nano zero-valent iron as a slow-release electron donor for sustained enhancement of aerobic denitrification in oligotrophic source water: Performance and mechanism.

Limited organic carbon in drinking water constrains the removal of nitrate‑nitrogen (NO-N) via aerobic denitrification. This paper reports the use of silica-coated nano zero-valent iron (nZVI@SiO) as a stable and sustainable electron donor to enhance aerobic denitrification. The nZVI@SiO, synthesized via a one-step method, was resistant to oxidation and exhibited excellent stability.

The utilization of Lysinibacillus bacterial powder to induce Fe plaque formation mitigates cadmium and chromium levels in rice.

The presence of cadmium (Cd) and chromium (Cr) contamination in soil poses an environmental risk to food safety. Microorganisms are crucial for biotransforming heavy metals, but their limited survival in contaminated soils hinders their application in bioremediation. Here, we isolated Lysinibacillus sp.

New insights into the remediation of chromium-contaminated industrial electroplating wastewater by an innovative nano-modified biochar derived from spent mushroom substrate: Mechanisms, batch study, stability and application.

To enhance the adsorption and detoxification capabilities of hexavalent chromium (Cr(VI)) using agricultural spent mushroom substrate (SMS), this study pioneered the preparation of biochar (NBC) from Lentinus edodes spent substrate. Subsequently, nano iron sulfide (FeS) particles were integrated onto NBC with carboxymethyl cellulose (CMC) as a stabilizer, resulting in a novel composite biosorption material, nFeS-BC. The adsorption and reduction potential of both NBC and nFeS-BC against Cr(VI) were evaluated through batch experiments, which identified pH as a critical factor influencing adsorption efficiency.