Hierarchical multi-label classification model for science and technology news based on heterogeneous graph semantic enhancement.

In the context of high-quality economic development, technological innovation has emerged as a fundamental driver of socio-economic progress. The consequent proliferation of science and technology news, which acts as a vital medium for disseminating technological advancements and policy changes, has attracted considerable attention from technology management agencies and innovation organizations. Nevertheless, online science and technology news has historically exhibited characteristics such as limited scale, disorderliness, and multi-dimensionality, which is extremely inconvenient for users of deep application.

Corrigendum: A comparative study of two PET verification methods in clinical cases.

[This corrects the article DOI: 10.3389/fonc.2021.

Corrigendum: Radioactivity and space range of ultra-low-activity for off-line PET verification of proton and carbon ion beam-a phantom study.

[This corrects the article DOI: 10.3389/fpubh.2021.

FBXO2 as a switch guides a special fate of tumor clones evolving into a highly malignant transcriptional subtype in oral squamous cell carcinoma.

Tumors comprise a heterogeneous collection of tumor cells with distinct genetic and phenotypic characteristics that differentially promote malignant progression. Therefore, it is essential to depict the heterogeneous landscape of clones for understanding the cancer biology and overcoming the resistance of cancer therapy. To determine the dynamic clonal feature of OSCC, we constructed the evolutionary trajectory of tumor cells based on single-cell RNA sequencing data.

[Corrigendum] Zoledronic acid sensitizes breast cancer cells to fulvestrant via ERK/HIF‑1 pathway inhibition .

Following the publication of the above article, the authors drew to the Editor's attention that they had inadvertently used the same immunohistochemical image to show the experiments depicting the zoledronic acid‑treated MCF‑7/HIF‑1α xenograft (the 'ZOL/MCF‑7/hif' panel) and the fulvestrant‑treated MCF‑7/vector xenograft (the 'FUL/MCF‑7/cdh' panel) in Fig. 3A on p. 5474.

Effect of super-high water materials backfilling on stress decrease and energy release during strip coal pillar mining: A case study.

Mining strip coal pillars left due to strip mining is important to resource-exhausted coal mines in eastern China. Backfilling mining is an effective means to mine strip coal pillars, which could decrease high stress and high energy release. However, materials with super-high water content were not widely applied in deeply isolated coal pillar mining due to lower strength characteristics and durability.

Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms.

Cullin-RING ligase 4 (CRL4) has attracted enormous attentions because of its extensive regulatory roles in a wide variety of biological and pathological events, especially cancer-associated events. CRL4 exerts pleiotropic effects by targeting various substrates for proteasomal degradation or changes in activity through different internal compositions to regulate diverse events in cancer progression. In this review, we summarize the structure of CRL4 with manifold compositional modes and clarify the emerging functions and molecular mechanisms of CRL4 in a series of cancer-associated events.

JARID2, a novel regulatory factor, promotes cell proliferation, migration, and invasion in oral squamous cell carcinoma.

Background: Accurate regulation of gene expression is crucial for normal development and function of cells. The prognostic significance and potential carcinogenic mechanisms of the related gene JARID2 in OSCC are not yet clear, but existing research has indicated a significant association between the two.

Methods And Materials: The relationship between the expression of the JARID2 gene in tumor samples of OSCC patients and clinical pathological factors was analyzed using immunohistochemistry experiments and RT-qPCR analysis.

An academic achievements visualization research in the past 30 years: research on rehabilitation for head and neck cancer.

Background: Head and neck cancer acts as the sixth most common malignant tumor worldwide with an increasing incidence. The needs and methods of its rehabilitation are diverse and constantly evolving.

Objective: This study aims to provide an in-depth depiction and visualization of the knowledge structure, hotspots, and emerging trends within the domain in the past 30 years through utilizing bibliometric analysis.

The Effect of Vidian Neurectomy on the Ocular Surface - The Primary Results from a Six-Month Pilot Study.

Purpose: To evaluate the effect of vidian neurectomy (VN) on the ocular surface and the possibility of dry eye in the treatment of allergic rhinitis.

Methods: Twelve participants were recruited in this prospective study. Prior to and after 1 and 6 months of VN, an ocular surface disease index (OSDI) questionnaire was obtained, and the Schirmer's tear test (STT), break-up time (BUT), corneal fluorescence staining (CFS) score, and Keratograph 5M were used to evaluate the ocular surface condition.

Evolution and impact of molecular glue research: a bibliometric analysis from 2000 to 2023.

Background: Molecular glues, which reshape E3 ligase receptors to promote targeted protein degradation, are emerging as a promising therapeutic strategy, particularly in oncology, driven by rapidly advancing insights into their mechanisms and structural properties.

Objective: This study aims to offer an insightful depiction and visualization of the knowledge structure, prevalent themes, and emerging trends within the domain since the year 2000, employing bibliometric analysis to achieve this goal.

Methods: To conduct this research, a comprehensive collection of literature on molecular glues was sourced from the Web of Science database.

circMTO1/miR-30c-5p/SOCS3 axis alleviates oral submucous fibrosis through inhibiting fibroblast-myofibroblast transition.

Background: circRNAs have been shown to participate in diverse diseases; however, their role in oral submucous fibrosis (OSF), a potentially malignant disorder, remains obscure. Our preliminary experiments detected the expression of circRNA mitochondrial translation optimization 1 homologue (circMTO1) in OSF tissues (n = 20) and normal mucosa tissues (n = 20) collected from Hunan Xiangya Stomatological Hospital, and a significant decrease of circMTO1 expression was showed in OSF tissues. Therefore, we further explored circMTO1 expression in OSF.

Hypoxia predicts favorable response to carbon ion radiotherapy in non-small cell lung cancer (NSCLC) defined by F-FMISO positron emission tomography/computed tomography (PET/CT) imaging.

Background: Hypoxia is the bottleneck that affects the response of conventional photon radiotherapy, but it does not seem to have much effect on carbon ion radiotherapy (CIRT). This study aimed to evaluate the changes of hypoxia before and after CIRT in patients with non-small cell lung cancer (NSCLC) and whether F-fluoromisonidazole (F-FMISO) positron emission tomography/computed tomography (PET/CT) imaging could predict the response to CIRT in NSCLC patients.

Methods: A total of 29 patients with NSCLC who received CIRT were retrospectively included.

An academic achievements visualization research since the 21st century: research on salvage surgery for head and neck cancer.

Background: Head and neck cancer is the 6th most common malignancy worldwide, and its incidence is still on the rise. The salvage surgery has been considered as an important treatment strategy for persistent or recurrent head and neck cancer. Therefore, we conducted a bibliometric analysis of salvage surgery for head and neck cancer since the 21st century.

Properties of [F]FAPI monitoring of acute radiation pneumonia versus [F]FDG in mouse models.

Objective: In this study, the uptake characteristics of [F]fibroblast activation protein inhibitor (FAPI) molecular imaging probe were investigated in acute radiation pneumonia and lung cancer xenografted mice before and after radiation to assess the future applicability of [F]FAPI positron emission tomography/computed tomography (PET/CT) imaging in early radiotherapy response.

Methods: Initially, the biodistribution of [F]FAPI tracer in vivo were studied in healthy mice at each time-point. A comparison of [F]FAPI and [F]fluorodeoxyglucose (FDG) PET/CT imaging efficacy in normal ICR, LLC tumor-bearing mice was evaluated.

Single-cell RNA sequencing reveals the complex cellular niche of pterygium.

Purpose: Pterygium is a vision-threatening conjunctival fibrovascular degenerated disease with a high global prevalence up to 12 %, while no absolute pharmacotherapy has been applied in clinics. In virtue of single-cell RNA sequencing (scRNA-seq) technique, our study investigated underlying pathogeneses and potential therapeutic targets of pterygium from the cellular transcriptional level.

Methods: A total of 45605 cells from pterygium of patients and conjunctiva of normal controls (NC) were conducted with scRNA-seq, and then analyzed via integrated analysis, pathway enrichment, pseudotime trajectory, and cell-cell communications.

Up modulation of dose-averaged linear energy transfer by simultaneous integrated boost in carbon-ion radiotherapy for pancreatic carcinoma.

Background: Local recurrence in locally advanced pancreatic cancer (LAPC) after carbon-ion radiotherapy (CIRT) may partly attribute to low dose-averaged linear energy transfer (LET), despite high CIRT dose.

Purpose: This study aimed to investigate the approaches to up-modulate the CIRT LET and to evaluate the corresponding oxygen enhancement ratio (OER) reduction.

Methods: 10 LAPCs that had been irradiated by CIRT with 67.

F-FAPI PET/CT performs better in evaluating mediastinal and hilar lymph nodes in patients with lung cancer: comparison with F-FDG PET/CT.

Background: The aim of this study was to evaluate the efficacy of fluorine 18 (F) labeled fibroblast activation protein inhibitor (FAPI) in identifying mediastinal and hilar lymph node metastases and to develop a model to quantitatively and repeatedly identify lymph node status.

Methods: Twenty-seven patients with 137 lymph nodes were identified by two PET/CT images. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of lymph node status were analyzed, and the optimal cut-off value was identified by ROC analysis.

Clinico-biological-radiomics (CBR) based machine learning for improving the diagnostic accuracy of FDG-PET false-positive lymph nodes in lung cancer.

Background: The main problem of positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging is the high false positive rate (FPR). Thus, we aimed to explore a clinico-biological-radiomics (CBR) model via machine learning (ML) to reduce FPR and improve the accuracy for predicting the hypermetabolic mediastinal-hilar LNs status in lung cancer than conventional PET/CT.

Methods: A total of 260 lung cancer patients with hypermetabolic mediastinal-hilar LNs (SUVmax ≥ 2.

Elevated 18 F-AIF-FAPI-04 Uptake in Hepatic Hemangioma.

A 67-year-old woman who was diagnosed with intrahepatic cholangiocellular carcinoma (CCC) by biopsy underwent 18 F-FDG and 18 F-AIF-FAPI-04 PET/CT for initial and treatment assessment. In addition to CCC, she had a history of hepatic hemangioma for 3 years. 18 F-FDG PET/CT images showed increased uptake in CCC, but no uptake in hemangiomas.

Extraction and Application of Hydraulic Support Safety Valve Characteristic Parameters Based on Roof Pressure Data.

The safety valves of powered supports control the maximum working resistance, and their statuses must be known to ensure the safety of both the support and the overlying strata. However, the inspection of powered support valves involves manual or semiautomated operations, the costs of which are high. In this study, an extreme point extraction method was developed for the determination of the characteristic parameters of safety valves using roof pressure data, and a safety valve state monitoring module was constructed.

The mechanism of IL-13 targeting IL-13Rα2 in regulating oral mucosal FBs through PI3K/AKT/mTOR.

Objective: The objective of this investigation was to examine the presence of interleukin (IL)-13 and its receptor IL-13Rα2 in the tissues of oral submucous fibrosis (OSF), investigate their biological functions, and explore the underlying mechanisms involved in the development of OSF.

Materials And Methods: The expression of IL-13 and IL-13Rα2 in the oral mucosa of patients with OSF and normal individuals was determined through immunohistochemistry and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Primary fibroblasts (FBs) were extracted through enzymatic digestion and then cultured.

Automated Stratum Interface Detection Using the Optimized Drilling Specific Energy through Self-Adaptive Logistic Function.

The precise detection of stratum interfaces holds significant importance in geological discontinuity recognition and roadway support optimization. In this study, the model for locating rock interfaces through change point detection was proposed, and a drilling test on composite strength mortar specimens was conducted. With the logistic function and the particle swarm optimization algorithm, the drilling specific energy was modulated to detect the stratum interface.