Publications by authors named "JingWen Xie"

Background: Due to its complex pathogenesis, the assessment of cancer-associated disseminated intravascular coagulation (DIC) is challenging. We aimed to develop a machine learning (ML) model to predict overt DIC in critically ill colorectal cancer (CRC) patients using clinical features and laboratory indicators.

Methods: This retrospective study enrolled consecutive CRC patients admitted to the intensive care unit from January 2018 to December 2023.

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Introduction: Bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, is widely used as a first-line treatment for metastatic colorectal cancer (mCRC), with hypertension being a common adverse effect. However, there is limited data on the predisposing factors contributing to bevacizumab-induced blood pressure (BP) elevation. This study aims to identify clinical risk factors associated with bevacizumab-related hypertension in patients with mCRC.

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The grape hyacinth is renowned for its profuse blue flowers, which confer substantial scientific and ornamental significance as well as considerable potential for industrial applications. The serine carboxypeptidase-like acyltransferases (SCPL-ATs) family is crucial for the blue flower coloration. To elucidate SCPL-ATs involved in anthocyanin modification in grape hyacinth, we performed a transcriptomic analysis of grape hyacinth SCPL-ATs.

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Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways.

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  • * Researchers studied 541 Ae. albopictus specimens from the Yangtze River Basin in China to analyze genetic mutations linked to insecticide resistance, focusing on the voltage-gated sodium channel (VGSC) gene.
  • * Their findings revealed multiple genotypes of kdr mutations, particularly significant variations at the 1016 locus and other loci, indicating diverse genetic backgrounds among mosquito populations in different regions.
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  • Oil emulsion (BJOE) is a traditional Chinese medicine used for treating lung cancer, but its active ingredients and mechanisms are not well understood.
  • This study identifies 13 active ingredients and confirms that certain compounds (β-sitosterol, luteolin, bruceitol) can effectively bind to key genes TP53 and MAPK1, impacting cancer treatment.
  • The findings reveal that luteolin is more effective than β-sitosterol at inhibiting lung cancer cell proliferation via the P53/MAPK1 signaling pathway, showcasing a comprehensive approach to treating cancer with BJOE.
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  • Cerebral ischemia-reperfusion injury (CIRI) is a serious problem in brain diseases caused by too much autophagy (cell cleanup) due to oxidative stress (damage from free radicals).
  • A new compound called X5 showed strong antioxidant properties, helping to reduce harmful effects from CIRI.
  • X5 was able to lower certain autophagy proteins and improve brain function in animal studies, suggesting it could be a potential treatment for CIRI in humans.
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Objectives: To perform a comprehensive bibliometric analysis of global publications on the applications of artificial intelligence (AI) in cardiology.

Methods: Documents related to AI in cardiology published between 2002 and 2022 were retrieved from Web of Science Core Collection. R package "bibliometrix", VOSviewers and Microsoft Excel were applied to perform the bibliometric analysis.

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Background: Anopheles stephensi is native to Southeast Asia and the Arabian Peninsula and has emerged as an effective and invasive malaria vector. Since invasion was reported in Djibouti in 2012, the global invasion range of An. stephensi has been expanding, and its high adaptability to the environment and the ongoing development of drug resistance have created new challenges for malaria control.

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Background: Recently, the effect of artificial light at night (ALAN) on the physiology and behavior of insects has gradually attracted the attention of researchers and has become a new research topic. Aedes albopictus is an important vector that poses a great public health risk. Further studies on the diapause of Ae.

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In this study, a series of novel compounds were synthesized by introducing the 3,4,5-trimethoxyphenyl and isatin groups into the monocarbonyl skeleton of curcumin. The possible biological activities and potential targets for these compounds were explored through network pharmacology. The results revealed that these compounds could significantly inhibit production of the inflammatory factors IL-6 and TNF-α, and suppress phosphorylation of the extracellular signal-regulated kinase (ERK) protein.

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Background: Pyroptosis, a cell death process triggered by chemotherapy drugs, has emerged as a highly promising mechanism for combating tumors in recent years. As the lead of new drugs, natural products play an important role in the discovery of anticancer drugs. Compared to other natural products, the medicine food homologous natural products (MFHNP) exhibit a superior safety profile.

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Mannose is a unique natural sugar that can be found in a variety of fruits and vegetables. During the past decades, mannose has been reported to be effective in promoting immune tolerance and suppressing inflammatory diseases. Metabolic dysfunction and altered inflammation have clear implications for the development and progression of inflammatory diseases.

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Mannan-binding lectin (MBL) is a pattern-recognition molecule that plays a crucial role in innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease (CKD). However, the molecular mechanisms are not fully defined.

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Background: Cell fusing agent virus (CFAV) was the first insect-specific virus to be characterized, and has been reported to negatively influence the growth of arboviruses such as dengue, Zika, and La Cross, making it a promising biocontrol agent for mosquito-borne disease prevention. Aedes aegypti Aag2 cells were naturally infected with CFAV. However, the ability of this virus to stably colonize an Ae.

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  • - Invasive alien species pose significant threats to ecosystems, the economy, and human health, necessitating surveillance and rapid response strategies to control their spread.
  • - A specific mosquito species from East Asia has expanded into Europe and Central Asia since 2008, and it is capable of spreading diseases like chikungunya virus.
  • - This study utilized the MaxEnt model to predict the current suitable distribution of this mosquito species globally, aiming to enhance monitoring and control efforts.
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Metastatic colorectal cancer (mCRC) patients are predisposed to venous thromboembolism (VTE). This study aimed to (1) evaluate the efficacy of 4 existing cancer-specific VTE models in predicting VTE incidence among hospitalized mCRC patients, and (2) examine the influence of incorporating mCRC molecular subtypes into these models. We conducted an evaluation of 4 cancer-specific VTE models, including Khorana, Vienna CATS, Protecht, and CONKO in a dataset involving 1392 mCRC patients.

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  • Aedes albopictus, also known as the Asian tiger mosquito, is one of the world's most invasive species and poses a serious risk to people's health.
  • Its spread is increasing because of things like international trade, people moving around, climate change, and more urban areas being built.
  • Researchers studied how this mosquito is spreading in China and found it is mostly in provinces like Yunnan and Guizhou, and it may continue to spread westward due to changing weather patterns.
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There is an ongoing trend to design new kinds of food packaging materials with excellent properties which are environmentally friendly enough. The aim of this study was to prepare and characterize egg white protein (EWP)-based composite films with and without ε-polylysine (Lys), as well as to compare their physical-chemical properties, structural properties, degradation and antibacterial properties. The results showed that with the addition of Lys, the composite films showed a decreasing tendency of the water permeability due to the enhanced interaction between proteins and water molecules.

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Aims: Vessel co-option is responsible for tumor resistance to antiangiogenic therapies (AATs) in patients with colorectal cancer liver metastasis (CRCLM). However, the mechanisms underlying vessel co-option remain largely unknown. Herein, we investigated the roles of a novel lncRNA SYTL5-OT4 and Alanine-Serine-Cysteine Transporter 2 (ASCT2) in vessel co-option-mediated AAT resistance.

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Background: Colorectal cancer (CRC) is a heterogeneous group of malignancies distinguished by distinct clinical features. The association of these features with venous thromboembolism (VTE) is yet to be clarified. Machine learning (ML) models are well suited to improve VTE prediction in CRC due to their ability to receive the characteristics of a large number of features and understand the dataset to obtain implicit correlations.

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  • A study developed chiral copper(I) cluster-assembled materials (R/S-2) that display unique photo-response traits in a DMSO solution, linked to concentration and wavelength.
  • Combined with a polymethyl methacrylate (PMMA) matrix, they created the first photo-activated circularly polarized luminescence (CPL) film, which emits a strong CPL signal when exposed to UV light.
  • The film demonstrates a reversible photo-response and excellent fatigue resistance, with underlying mechanisms involving aggregation-induced emission (AIE) and a photo-induced deoxygenation process.
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An alcohol dehydrogenase LkADH was successfully engineered to exhibit improved activity and substrate tolerance for the production of (S)-2-chloro-1-(3,4-difluorophenyl)ethanol, an important precursor of ticagrelor. Five potential hotspots were identified for enzyme mutagenesis by using natural residue abundance as an indicator to evaluate their potential plasticity. A semi-rational strategy named "aromatic residue scanning" was applied to randomly mutate these five sites simultaneously by using tyrosine, tryptophan, and phenylalanine as "exploratory residues" to introduce steric hindrance or potential π-π interactions.

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The twenty-first century has already recorded more than ten major epidemics or pandemics of viral disease, including the devastating COVID-19. Novel effective antivirals with broad-spectrum coverage are urgently needed. Herein, we reported a novel broad-spectrum antiviral compound PAC5.

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Chronic inflammation of white adipose tissue is a key link between obesity and the associated metabolic syndrome. Transient receptor potential melastatin-like 7 (TRPM7) is known to be related to inflammation; however, the role of TRPM7 in adipocyte phenotype and function in obesity remains unclear. Here, we observe that the activation of adipocyte TRPM7 plays an essential role in pro-inflammatory responses.

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