Inverse design of metalenses with polarization and chromatic dispersion modulation via transfer learning.

Polarization and wavelength multiplexed metalenses address the bulkiness of traditional imaging systems. However, despite progress with numerical simulations and parameter scanning, the engineering complexity of classical methods highlights the urgent need for efficient deep learning approaches. This paper introduces a deep learning-driven inverse design model for polarization-multiplexed metalenses, employing propagation phase theory alongside spectral transfer learning to address chromatic dispersion challenges.

Selective oxidation of ammonium to dinitrogen by a novel catalytic ozonation system: Regulating the N selectivity by sulfite.

The selective oxidation of NH-N into dinitrogen (N) is still a challenge. Currently, traditional advanced oxidation processes often involve in the chlorine free radicals to increase the selectivity of NH-N oxidation products towards N but is usually accompanied by the production of many toxic disinfection by-product. Herein, we reported a novel catalytic ozonation system (UV/O/MgO/NaSO) for selective NH-N oxidation based on the reducing capability and photochemical properties of NaSO.

Interfacial hydrogen bonds induced by porous FeCr bimetallic atomic sites for efficient oxygen reduction reaction.

Interfacial hydrogen bonds are pivotal in enhancing proton activity and accelerating the kinetics of proton-coupled electron transfer during electrocatalytic oxygen reduction reaction (ORR). Here we propose a novel FeCr bimetallic atomic sites catalyst supported on a honeycomb-like porous carbon layer, designed to optimize the microenvironment for efficient electrocatalytic ORR through the induction of interfacial hydrogen bonds. Characterizations, including X-ray absorption spectroscopy and in situ infrared spectroscopy, disclose the rearrangement of delocalized electrons due to the formation of FeCr sites, which facilitates the dissociation of interfacial water molecules and the subsequent formation of hydrogen bonds.

Interleukin-3 Modulates Macrophage Phagocytic Activity and Promotes Spinal Cord Injury Repair.

Background: Effective clearance of lipid-rich debris by macrophages is critical for neural repair and regeneration after spinal cord injury (SCI). Interleukin-3 (IL-3) has been implicated in programming microglia to cluster and clear pathological aggregates in neurodegenerative disease. Yet, the influence of IL-3 on lipid debris clearance post-SCI is not well characterized.

The therapeutic effects of salvianolic acids on ischemic stroke: From molecular mechanisms to clinical applications.

Ischemic stroke (IS), primarily caused by cerebrovascular occlusion, poses a significant public health challenge with limited effective therapeutic options. Evidence suggests that salvianolic acids (SAs), mainly from Salvia miltiorrhiza Bunge, have been formulated into injections and are widely used in clinical treatments for cardiovascular and cerebrovascular diseases, including stroke. The pharmacological properties of SAs include reducing neuroinflammation, alleviating oxidative stress injury, inhibiting cellular apoptosis, preserving endothelial function, maintaining blood-brain barrier integrity, and promoting angiogenesis.

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.

RNA polymerase II progression from initiation to elongation is driven in part by a cascade of protein kinases acting on the core transcription machinery. Conversely, the corresponding phosphatases, notably PP2A and PP1-the most abundant serine-threonine phosphatases in cells-are thought to mainly impede polymerase progression, respectively restraining pause release at promoters and elongation at terminators. Here, we reveal an unexpected role of PP1, within the phosphatase 1 nuclear targeting subunit (PNUTS)-PP1 complex, in sustaining global transcriptional activation in human cells.

Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice.

Diet-induced metabolic dysfunction steatotic liver disease (MASLD) is also called as non-alcoholic fatty liver disease (NAFLD) with limited effective strategies available. We previously have shown that chikusetsusaponin IVa (CHS), a dietary saponin from herbs in South American known for their metabolic benefits, mitigates diet-induced diabetes. In this study we investigated the beneficial effects of CHS on MASLD and the underlying mechanisms.

Genipin-crosslinked hydrogels for food and biomedical applications: A scientometric review.

Genipin, a precursor of dietary blue pigment, is a promising alternative for industrial applications in food and health. Due to its ability to simultaneously satisfy biosafety requirements and provide crosslinking effects, genipin has attracted considerable attention for food and biomedical applications. In this review, we attempt to shed light on the progress in genipin research using scientometrics.

Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity.

We prepared biocompatible and environment-friendly zinc oxide nanoparticles (ZnO NPs) with upconversion properties and catalase-like nanozyme activity. Photodynamic therapy (PDT) application is severely limited by the poor penetration of UV-Visible light and a hypoxic tumor environment. Here, we used ZnO NPs as a carrier for the photosensitizer chlorin e6 (Ce6) to construct zinc oxide-chlorin e6 nanoparticles (ZnO-Ce6 NPs), simultaneously addressing both problems.

Opto-Electrical Decoupled Phototransistor for Starlight Detection.

Highly sensitive shortwave infrared (SWIR) detectors are essential for detecting weak radiation (typically below 10 W·Sr·cm·µm) with high-end passive image sensors. However, mainstream SWIR detection based on epitaxial photodiodes cannot effectively detect ultraweak infrared radiation due to the lack of inherent gain. Here, we develop a heterojunction-gated field-effect transistor (HGFET) consisting of a colloidal quantum dot (CQD)-based p-i-n heterojunction and a carbon nanotube (CNT) field-effect transistor, which achieves a high inherent gain based on an opto-electric decoupling mechanism for suppressing noise.

Systems Pharmacology to Explore the Potential Mechanism of Ginseng Against Heart Failure.

The aim of this study is to elucidate the pharmacological mechanism underlying the effects of Ginseng Radix et Rhizoma (ginseng) in heart failure (HF), providing a theoretical foundation for its clinical application. The potential mechanism of ginseng in the context of HF was investigated using systems pharmacology that combined network pharmacology, Gene Expression Omnibus (GEO) analysis, molecular docking, and experimental verification. Network pharmacology was employed to identify drug-disease targets.

Global research progress in pharmacy education.

Introduction: Bibliometric and visualization analyses are used to quantitatively assess and graphically display the current status, patterns, and trends using scholarly literature. Pharmacy education worldwide has developed rapidly over the past few decades, but few related studies have been conducted in this field. This study aims to explore the present landscape, identify research focal points, and future trends in the evolution of pharmacy education.

Methyl-β-cyclodextrin Enhances Tumor Cellular Uptake and Accumulation of α-Linolenic Acid-Paclitaxel Conjugate Nanoparticles.

Improving nanomedicine uptake by tumor cells is key to achieving intracellular drug delivery. In this study, we found that methyl-β-cyclodextrin (MβCD) can significantly promote the intracellular accumulation of nanoparticulated α-linolenic acid-paclitaxel conjugates (ALA-PTX NPs) via enhanced clathrin-mediated endocytosis and limited degradation in lysosomes. Our in vitro results indicated that MβCD not only reduced the plasma membrane cholesterol content and increased plasma membrane fluidity, leading to ALA-PTX NPs being more easily incorporated into the plasma membrane, further enhancing membrane fluidity and making the plasma membrane more susceptible to tensile deformation, forming intracellular vesicles to enhance ALA-PTX NP cellular uptake, but also destroyed lysosomes and then limited ALA-PTX NPs' degradation in lysosomes.

Source-specific health risks of PM-bound toxic metals in Wuhai, a semi-arid city in northwest China.

Quantifying the individual impact of each PM-containing source on increasing health risk is essential for mitigating the harmful effects of atmospheric pollutants to human health. However, there remains a limited understanding of these health risks and their association with sources in semi-arid cities. To address this lack of understanding, 20 PM-bound toxic metals (PTMs) were observed at six sampling sites in Wuhai, a typical semi-arid city in northwest China.

Functional antimicrobial peptide-loaded 3D scaffolds for infected bone defect treatment with AI and multidimensional printing.

Infection is the most prevalent complication of fractures, particularly in open fractures, and often leads to severe consequences. The emergence of bacterial resistance has significantly exacerbated the burden of infection in clinical practice, making infection control a significant treatment challenge for infectious bone defects. The implantation of a structural stent is necessary to treat large bone defects despite the increased risk of infection.

Targeting IL-17 and its receptors: A feasible way for natural herbal medicines to modulate fibroblast-like synoviocytes in rheumatoid arthritis.

Rheumatoid arthritis (RA) is characterized by processive synovial hyperplasia and abnormal proliferation of fibroblast-like synoviocytes (FLSs), and can eventually lead to progressive joint destruction. Increasing evidence has demonstrated that cytokines play pivotal roles in the pathogenesis of RA. In particular, the production of interleukin (IL)-17 by T helper 17 (Th17) cells is closely associated with the development of RA, and inhibition of IL-17/IL-17R could regulate the production of inflammatory factors by FLSs, which may be a feasible way to reduce inflammation and bone destruction in RA.

Bidirectional Photovoltage-Driven Oxide Transistors for Neuromorphic Visual Sensors.

Biological vision is one of the most important parts of the human perception system. However, emulating biological visuals is challenging because it requires complementary photoexcitation and photoinhibition. Here, the study presents a bidirectional photovoltage-driven neuromorphic visual sensor (BPNVS) that is constructed by monolithically integrating two perovskite solar cells (PSCs) with dual-gate ion-gel-gated oxide transistors.

Capsiate Improves Glucose Metabolism by Improving Insulin Sensitivity in Diabetic Retinopathy Mice.

Purpose: Capsiate (cap) is a metabolite that affects a number of biological processes, and diabetic retinopathy (DR) is now known to be the primary cause of end-stage eye illness.

Methods: In order to examine the effects of the cap intervention on body weight, nutritional intake, changes in body weight composition, glucose metabolism levels, retinopathy, and oxidative stress levels, we proposed using a mouse model of diabetic retinopathy caused by STZ.

Results: Our findings demonstrated that, in addition to increasing lean body mass and lowering fat body mass content, cap intervention significantly improved body weight and dietary consumption in STZ mice.

Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice.

Background: In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor beta (PDGFRβ) fibroblasts. Galectin-3, a carbohydrate-binding protein of the lectin family, is notably expressed by infiltrating hematogenous macrophages and mediates cell-cell interactions. Although Galectin-3 has been shown to contribute to the endocytic internalization of PDGFRβ in vitro, its specific role in driving fibrotic scar formation after SCI has not been determined.

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis.

Malaria parasites hijack the metabolism of their mammalian host during the blood-stage cycle. Anopheles mosquitoes depend on mammalian blood to lay eggs and to transmit malaria parasites. However, it remains understudied whether changes in host metabolism affect parasite transmission in mosquitoes.