New Antifouling Dual Iron-Based Photo-Fenton Catalytic Membrane Dedicated to Long-Term Treatment of Oils and Dyes.

Combining the photo-Fenton catalytic reaction with membrane separation technology can effectively treat oils and dyes in water. However, single iron-based catalysts suffer from limited photogenerated carrier utilization and slow Fe/Fe redox reactions, leading to membrane contamination. In this study, iron oxyhydroxide and Prussian blue were grown on a PVDF membrane, optimizing electron transfer to improve the catalytic efficiency (the methylene blue degradation efficiency was nearly 50% in 10 min and the reaction rate constant was 0.

The Deletion of the MGF360-10L/505-7R Genes of African Swine Fever Virus Results in High Attenuation but No Protection Against Homologous Challenge in Pigs.

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a severe hemorrhagic disease with a mortality rate reaching 100%. Despite extensive research on ASFV mechanisms, no safe and effective vaccines or antiviral treatments have been developed. Live attenuated vaccines generated via gene deletion are considered to be highly promising.

Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway.

Introduction: Cerebral ischemia-reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. However, whether IR induces ferroptosis in brain microvascular endothelial cells (BMVECs) is not fully understood.

Zero-Trust Access Control Mechanism Based on Blockchain and Inner-Product Encryption in the Internet of Things in a 6G Environment.

Within the framework of 6G networks, the rapid proliferation of Internet of Things (IoT) devices, coupled with their decentralized and heterogeneous characteristics, presents substantial security challenges. Conventional centralized systems face significant challenges in effectively managing the diverse range of IoT devices, and they are inadequate in addressing the requirements for reduced latency and the efficient processing and analysis of large-scale data. To tackle these challenges, this paper introduces a zero-trust access control framework that integrates blockchain technology with inner-product encryption.

High-Performance Triple-Network Hydrogels Derived from Chrome Leather Scraps: Ultrahigh Compressive Strength, Adhesion, and Self-Recovery.

The development of engineered hydrogels with high strength, self-recovery, and adhesion is essential for applications requiring resistance to large deformations and cyclic loading. Herein, a triple-network (TN) hydrogel with ultrahigh compressive strength, strong adhesion, and good self-recovery was constructed by using tannic acid-modified chrome leather scrap hydrolysate as the first network, polyacrylamide as the second network, and poly-2-propenamide-2-methylpropanesulfonic acid as the third network. The ultrahigh (70 MPa compressive strength and 95% compression deformation) TN hydrogels were effectively created, which is attributed to the synergy of the three networks.

MYBBP1A‑mediated IGFBP4 promoter methylation promotes epithelial‑mesenchymal transition and metastasis through activation of NOTCH pathway in liver cancer.

Metastatic hepatocellular carcinoma (HCC) seriously threatens patients' prognosis. It was previously suggested that the insulin growth factor binding protein (IGFBP) family could serve as cancer suppressors in the development and metastasis of HCC. However, the role of IGFBP4 and its underlying molecular mechanism in HCC metastasis is elusive.

Development and validation of a machine learning model to predict the risk of readmission within one year in HFpEF patients: Short title: Prediction of HFpEF readmission.

Background: Heart failure with preserved ejection fraction (HFpEF) is associated with elevated rates of readmission and mortality. Accurate prediction of readmission risk is essential for optimizing healthcare resources and enhancing patient outcomes.

Methods: We conducted a retrospective cohort study utilizing HFpEF patient data from two institutions: the First Affiliated Hospital Zhejiang University School of Medicine for model development and internal validation, and the Affiliated Hospital of Xuzhou Medical University for external validation.

The diagnostic value of hydroxyproline combined with tuberculosis infection T lymphocyte spot assay in pulmonary tuberculosis.

Background: Tuberculosis (TB) is an infectious disease which has long threatened human health, and new molecular diagnostic markers for its diagnosis are urgently needed. The study was designed to analyze the expression of hydroxyproline (HYP) in different specimens of pulmonary TB (PTB) and assess its auxiliary diagnostic value alone or in combination with the TB infection T lymphocyte spot assay (TSPOT.TB).

Using reverse vaccinology techniques combined with B-cell epitope prediction to screen potential antigenic proteins of the bovine pathogen Clostridium perfringens type A.

Clostridium perfringens type A frequently causes necrohaemorrhagic enteritis in cattle, a rapidly progressing disease with a high mortality rate, thus inflicting substantial economic losses in the cattle industry. Effective prevention and control of this disease rely on rapid detection and vaccination strategies, making the screening of antigenic proteins with diagnostic and vaccine potential particularly crucial. In this study, we conducted a pangenomic analysis of 15 bacterial strains, grounded in traditional reverse vaccinology and supplemented with B-cell linear and conformational epitope analysis tools.

PQSF: post-quantum secure privacy-preserving federated learning.

In federated learning, secret sharing is a key technology to maintain the privacy of participants' local models. Moreover, with the rapid development of quantum computers, existing federated learning privacy protection schemes based on secret sharing will no longer be able to guarantee the data security of participants in the post-quantum era. In addition, existing privacy protection methods have the problem of high communication and computational overhead.

Analysis on childhood fever health information seeking behaviors in online health community using a mixed-methods approach.

Objective: The primary aim of this study is to analyze health information seeking behaviors of users related to child fever within online health communities. The findings will serve as a foundation for the development of targeted interventions and resources for addressing the specific information needs related to child fever. Ultimately, this will enhance parental capabilities in managing fever in children and for improving the quality of communication between healthcare professionals and parents dealing with feverish children.

Factors Associated with Nonalcoholic Fatty Liver Disease in a Non-Overweight/Obese and Overweight/Obese Chinese Population at Risk for Metabolic Syndrome: A Cross-Sectional Multicenter Study.

To investigate the association of demographic, clinical, and metabolic factors with nonalcoholic fatty liver disease (NAFLD) in a non-overweight/obese and overweight/obese Chinese population at risk for metabolic syndrome. A cross-sectional multicenter study was conducted using convenience sampling from eight selected counties/cities in Zhejiang, China, between May 2021 and September 2022. Demographics, epidemiological, anthropometric, and clinical characteristics were obtained from a questionnaire.

Bibliometric analysis of research on gut microbiota and bile acids: publication trends and research frontiers.

The gut microbiota is widely regarded as a "metabolic organ" that could generate myriad metabolites to regulate human metabolism. As the microbiota metabolites, bile acids (BAs) have recently been identified as the critical endocrine molecules that mediate the cross-talk between the host and intestinal microbiota. This study provided a comprehensive insight into the gut microbiota and BA research through bibliometric analysis from 2003 to 2022.

A 10-year retrospective cohort of diabetic patients in a large medical institution: Utilizing multiple machine learning models for diabetic kidney disease prediction.

Objective: As the prevalence of diabetes steadily increases, the burden of diabetic kidney disease (DKD) is also intensifying. In response, we have utilized a 10-year diabetes cohort from our medical center to train machine learning-based models for predicting DKD and interpreting relevant factors.

Methods: Employing a large dataset from 73,101 hospitalized type 2 diabetes patients at The First Affiliated Hospital of Zhengzhou University, we analyzed demographic and medication data.

Biofilm Formation, Motility, and Virulence of Are Reduced by Deletion of the Gene , a Novel Listerial LPXTG Surface Protein.

Listeria monocytogenes () is a foodborne pathogen that causes listeriosis in humans and other animals. Surface proteins with the LPXTG motif have important roles in the virulence of . Lmo0159 is one such protein, but little is known about its role in virulence, motility, and biofilm formation.

EⅡB Mutation Reduces the Pathogenicity of by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression.

To explore the role of the membrane permease ⅡB (EⅡB) gene of pathogenicity island 4 (LIPI-4) in the virulence of , both an EⅡB deletion strain (∆EⅡB) and a complemented strain were constructed. In vitro experiments demonstrated that EⅡB deletion affected the biofilm formation ability of the wild-type strain (Lm928). Moreover, this deletion decreased the intracellular proliferation abilities of .

GP's GP, general practitioner's health and willingness to contract family doctors in China: a national cross-sectional study.

Objectives: General practitioners are trained to care for patients with a high level of responsibility and professional competency. However, there are few reports on the physical and mental health status of general practitioners (GPs) in China, particularly regarding help seeking and self-treatment. The primary aims of this study were to explore GPs' expectations of their own family doctors and their reflection on role positioning, and to explore the objective factors that hinder the system of family doctors.

Associations between low muscle mass and clinical characteristics of health population in China.

Objectives: The primary aim of this study is to discern the association between specific clinical parameters and low muscle mass (LMM). We endeavor to elucidate the determinants of LMM and the predictive potency of individual factors.

Methods: In this retrospective cross-sectional study, we encompassed 450 older adult Chinese participants (252 males and 198 females).

Halide-free CO cycloaddition onto styrene oxide catalysed by first row transition-metal derivatives of polyoxotungstates.

Quaternary ammonium salts of metal derivatives of polyoxometalates [XWOM(HO)] (X = P, Si; M = Cr, Mn, Co, Ni, Zn) were successfully tested instead of quaternary ammonium halides as catalysts in the cycloaddition of CO to styrene oxide. Remarkably, they gave very satisfactory yields of styrene carbonate at moderate temperature (80 °C).

Vimentin inhibits peste des petits ruminants virus replication by interaction with nucleocapsid protein.

The Peste des petits ruminant virus (PPRV) is a member of the Paramyxoviridae family and is classified into the genus Measles virus. PPRV predominantly infects small ruminants, leading to mortality rates of nearly 100%, which have caused significant economic losses in developing countries. Host proteins are important in virus replication, but the PPRV nucleocapsid (N) protein-host interacting partners for regulating PPRV replication remain unclear.

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways.

The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control. In this study, we designed a porcine genome-scale CRISPR/Cas9 knockout library containing 93,859 single guide RNAs targeting 16,886 protein-coding genes, 25 long ncRNAs, and 463 microRNAs. Using this library, several previously unreported genes required for FMDV infection are highly enriched post-FMDV selection in IBRS-2 cells.

Plasminogen activator urokinase interacts with the fusion protein and antagonizes the growth of Peste des petits ruminants virus.

Peste des petits ruminants is an acute and highly contagious disease caused by the Peste des petits ruminants virus (PPRV). Host proteins play a crucial role in viral replication. However, the effect of fusion (F) protein-interacting partners on PPRV infection is poorly understood.

African Swine Fever Virus I267L Is a Hemorrhage-Related Gene Based on Transcriptome Analysis.

African swine fever (ASF) is an acute and severe disease transmitted among domestic pigs and wild boars. This disease is notorious for its high mortality rate and has caused great losses to the world's pig industry in the past few years. After infection, pigs can develop symptoms such as high fever, inflammation, and acute hemorrhage, finally leading to death.