Numerical simulation of three-dimensional seepage field in a tailing pond under multiple operating conditions.

Establishing strong seepage stability for tailings dams is crucial for ensuring their safety and mitigating the risk of failure. This study developed a three-dimensional seepage numerical model using finite element numerical computation for four different elevation conditions (5070 m, 5081 m, 5159 m, and 5213 m) encompassing the pond area and dam body. Seepage calculations were conducted under normal and flooding conditions, and the tailings pond's seepage stability was assessed for various stacking scenarios.

Exploring the long-term performance of air purifiers in removing particulate matter and formaldehyde across different residential environments.

Household air purifiers are widely used to enhance indoor air quality. However, limited information exists regarding the factors that influence their long-term performance. This study investigates the impact of various residential environments on the long-term efficacy of air purifiers.

[Preparation of a mouse monoclonal antibody against the NS1 protein of respiratory syncytial virus].

The aim of this study was to prepare a mouse monoclonal antibody against the nonstructural protein 1 (NS1) of respiratory syncytial virus (RSV) to analyze its expression and distribution during transfection and infection. Additionally, we aimed to evaluate the antibody's application in immunoprecipitation assay. Firstly, the NS1 gene fragment was cloned into a prokaryotic plasmid and expressed in .

The multiple roles of viral 3D protein in picornavirus infections.

The are a large group of positive-sense, single-stranded RNA viruses, and most research has focused on the Enterovirus genus, given they present a severe health risk to humans. Other picornaviruses, such as foot-and-mouth disease virus (FMDV) and senecavirus A (SVA), affect agricultural production with high animal mortality to cause huge economic losses. The 3D protein of picornaviruses is widely known to be used for genome replication; however, a growing number of studies have demonstrated its non-polymerase roles, including modulation of host cell biological processes, viral replication complex assembly and localization, autophagy, and innate immune responses.

Study progress on the pipeline transportation safety of hydrogen-blended natural gas.

The core of carbon neutrality is the energy structure adjustment and economic structure transformation. Hydrogen energy, as a kind of clean energy with great potential, has provided important support for the implementation of the carbon peaking and carbon neutrality goals of China. How to achieve the large-range, safe, and reliable transportation of hydrogen energy with good economic benefits remains the key to limiting the development of hydrogen energy.

Pathogenicity and virulence of human respiratory syncytial virus: Multifunctional nonstructural proteins NS1 and NS2.

Human respiratory syncytial virus (hRSV) is a major cause of acute lower respiratory tract infections in children under the age of two as well as in the elderly and immunocompromised worldwide. Despite its discovery over 60 years ago and the global impact on human health, limited specific and effective prophylactic or therapeutic options have been available for hRSV infections. Part of the lack of treatment options is attributed to the legacy of vaccine failure in the 1960s using a formalin-inactivated RSV (FI-RSV), which led to enhancement of disease post exposure to hRSV infection and hampered subsequent development of vaccine candidates.

Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0-5 years old: a preliminary longitudinal study.

To explore the application value of early standardized management in the delivery of neonates of pregnant women with gestational diabetes mellitus (GDM). Parturient diagnosed with GDM and their offspring were selected in our hospital from January 1, 2015 to December 31, 2017 to underwent early standardized management. Non-GDM pregnant women and their offspring were selected as the control group.

The characteristic of competitive adsorption of HCHO and CH on activated carbon by molecular simulation.

To explore the characteristic of competitive adsorption of formaldehyde (HCHO) and benzene(CH) on activated carbon, the slit models of activated carbon with different pore sizes of 1 nm, 2 nm and 4 nm were constructed by using the Visualizer module of Materials Studio molecular simulation software. The adsorption of single-component CH and HCHO at three different temperatures of 288.15K,293.

Targeting BCAA metabolism to potentiate metformin's therapeutic efficacy in the treatment of diabetes in mice.

Aims/hypothesis: An increasing body of evidence has shown that the catabolism of branched-chain amino acids (BCAAs; leucine, isoleucine and valine) is impaired in obese animals and humans, contributing to the development of insulin resistance and type 2 diabetes. Promoting BCAA catabolism benefits glycaemic control. It remains unclear whether BCAA catabolism plays a role in the therapeutic efficacy of currently used glucose-lowering drugs such as metformin.

The relationship between screen time and attention deficit/hyperactivity disorder in Chinese preschool children under the multichild policy: a cross-sectional survey.

Background: Long screen time has become a public health problem that cannot be ignored. The association between screen time and attention-deficit/hyperactivity disorder (ADHD) in preschool children has received widespread attention.

Methods: A questionnaire was used to survey 2452 people.

Association between low blood selenium concentrations and poor hand grip strength in United States adults participating in NHANES (2011-2014).

The trace element selenium, which is found in selenoproteins, plays an antioxidant role in preventing muscle tissue injury. A positive association between selenium concentrations and hand grip strength has been reported in older adults; however, the evidence of this association is scarce in general adults. In this study, we aimed to evaluate the association between blood selenium concentrations and low hand grip strength using the data from the National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 in the United States (US).

Research on the Maturity Evaluation Model of Enterprise Safety Culture.

To regulate the safety behavior of employees and improve the occupational safety level of enterprises. Based on the perspective of safety culture, this paper designed an index system based on the four dimensions of safety concept, system, behavior, and physical culture, and it explored a new quantitative assessment method of safety culture level by introducing the concept of maturity into the evaluation of safety culture using the grey fuzzy comprehensive evaluation method. Combining the characteristics of enterprise safety culture, safety culture was divided into five levels, including original level, starting level, development level, completion level, and leading level, and the maturity model of enterprise safety culture was established.

The Foot-and-Mouth Disease Virus Lb Protease Cleaves Intracellular Transcription Factors STAT1 and STAT2 to Antagonize IFN-β-Induced Signaling.

Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease, one of the most highly infectious animal viruses throughout the world. The JAK-STAT signaling pathway is a highly conserved pathway for IFN-β-induced antiviral gene expression. Previous studies have shown that FMDV can strongly suppress the innate immune response.

A model to evaluate ozone distribution and reaction byproducts in aircraft cabin environments.

Ozone and byproducts of ozone-initiated reactions are among the primary pollutants in aircraft cabins. However, investigations of the spatial distribution and reaction mechanisms of these pollutants are insufficient. This study established a computational fluid dynamics-based model to evaluate ozone and byproduct distribution, considering ozone reactions in air, adsorption onto surfaces, and byproduct desorption from surfaces.

Working memory-related alterations in neural oscillations reveal the influence of in-vehicle toluene on cognition at low concentration.

Although toluene is a typical in-vehicle pollutant, the impacts of in-vehicle toluene exposure on cognitive functions remain unestablished. Therefore, this study aimed to investigate the effects of short-term toluene exposure in vehicles on working memory based on neural oscillations. In total, 24 healthy adults were recruited.

Sildenafil Inhibits the Growth and Epithelial-to-mesenchymal Transition of Cervical Cancer via the TGF-β1/Smad2/3 Pathway.

Aims: The study aims to explore new potential treatments for cervical cancer.

Background: Cervical cancer is the second most common cancer in women, causing >250,000 deaths worldwide. Patients with cervical cancer are mainly treated with platinum compounds, which often cause severe toxic reactions.

Prediction and Analysis of Contemporary College Students' Mental Health Based on Neural Network.

For an ordinary student who has just graduated from high school, interpersonal communication and performance evaluation on campus is also a huge challenge. In order to solve the future and current competition and pressure faced by contemporary college students, many college students have mental health problems. This paper evaluates, predicts, and analyzes the mental health status of contemporary college students based on a neural network algorithm.

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge.

Multigene family (MGF) gene products are increasingly reported to be implicated in African swine fever virus (ASFV) virulence and attenuation of host defenses, among which the MGF360-9L and MGF505-7R gene products are characterized by convergent but distinct mechanisms of immune evasion. Herein, a recombinant ASFV mutant, ASFV-Δ9L/Δ7R, bearing combinational deletions of MGF360-9L and MGF505-7R, was constructed from the highly virulent ASFV strain CN/GS/2018 of genotype II that is currently circulating in China. Pigs inoculated intramuscularly with 10 50% hemadsorption doses (HAD) of the mutant remained clinically healthy without any serious side effects.

FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication.

The RIG-I-like receptor signaling pathway is crucial for producing type I interferon (IFN-I) against RNA viruses. The present study observed that viral infection increased annexin-A1 (ANXA1) expression, and ANXA1 then promoted RNA virus-induced IFN-I production. Compared to ANXA1 wild-type cells, ANXA1 knockout cells showed IFN-β production decreasing after viral stimulation.

Senecavirus a 3D Interacts with NLRP3 to Induce IL-1β Production by Activating NF-κB and Ion Channel Signals.

Senecavirus A (SVA) infection induces inflammation in animals, such as fever, diarrhea, vesicles and erosions, and even death. The inflammatory cytokine interleukin-1β (IL-1β) plays a pivotal role in inflammatory responses to combat microbes. Although SVA infection can produce inflammatory clinical symptoms, the modulation of IL-1β production by SVA infection remains unknown at present.

Urban Stormwater Resilience Assessment Method Based on Cloud Model and TOPSIS.

To scientifically and quantitatively evaluate the degree of urban storm resilience and improve the level of urban stormwater resilience, based on the resilience theory, starting from the three attributes of resilience (resistance, recovery and adaptability), this paper establishes the framework of urban resilience evaluation indicator system under the background of stormwater disaster. Firstly, the weight of the indicator system is analyzed by the Delphi method and cloud model, and then the urban stormwater recilience evaluation model is constructed by using the cloud model and approximate ideal solution ranking method. Through the fuzzy description, the corresponding quantitative value is given to the qualitative indicator, so that the stormwater resilience of the city can be measured by accurate values.

Rapid identification of candidate genes controlling male-sterility in Foxtail millet ().

Unlabelled: Photo-(thermo-) sensitive genic male-sterile line is the key component of two-line hybridization system in foxtail millet (), but the genetic basis of male sterility in most male-sterile lines is still unclear. In the present study, a large F population was developed derived from a cross between the photo-(thermo-) sensitive male-sterile line A2 and the fertile-line 1484-5. Thirty plants with extreme high and extreme low fertility were selected from the population to construct a sterile DNA pool and a fertile DNA pool, respectively.