Exploring geriatric syndromes among physically disabled older adults: A network analysis.

Objective: To explore the network structure of common geriatric syndromes and conditions in physically disabled older adults.

Methods: We chose fourteen common geriatric syndromes and conditions from the dataset and estimated networks with the partial correlation network method. We tested the stability and accuracy of the network using the package "bootnet" in R software.

Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy.

Hypoxic tumors present a significant challenge in cancer therapy due to their ability to adaptation in low-oxygen environments, which supports tumor survival and resistance to treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is a crucial mechanism that helps sustain cellular homeostasis in hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, that co-delivers hydroxychloroquine and a mitochondria-targeting photosensitizer, designed to induce cascaded oxidative stress by regulating mitophagy for the treatment of hypoxic tumors.

Deficiency of ATF3 facilitates both angiotensin II-induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS-STING pathway.

Background: Sporadic aortic aneurysm and dissection (AAD) is a critical condition characterised by the progressive loss of vascular smooth muscle cells (VSMCs) and the breakdown of the extracellular matrix. However, the molecular mechanisms responsible for the phenotypic switch and loss of VSMCs in AAD are not fully understood.

Methods And Results: In this study, we employed a discovery-driven, unbiased approach.

Gender difference in the association between volunteering and health-related quality of life among hearing-impaired older adults in China.

Background: The present study aims to assess the relationship between volunteering and health-related quality of life (HRQoL) among older adults with hearing impairment, as well as the gender difference in this association.

Methods: We use data from the sixth Health Service Survey of Shandong Province, China. The survey interviewed 35,264 respondents, from which a total of 1,457 hearing-impaired older adults were included in the study.

Patterns of Comorbidity, Disability, and Home Health Care Service for Older Adults With Physical Disability: A Latent Class Analysis and Visualized Illustration.

Understanding the relationships between comorbidity, disability, and home health-care services aids in user-centered care design. This study identifies patterns of these factors among older adults with physical disability living at home and explores their associations. This cross-sectional study included community-dwelling older adults assessed for Long-term Care Insurance from September 1 to December 31, 2018, in Yiwu, Zhejiang, China.

Signing contracts for family doctors, functional limitations and home care willingness among older adults: a cross-sectional study.

Background: Traditional Chinese culture advocates home care be provided by family members. Home care can improve mental health and enjoy a familiar environment for older people. This study aimed to investigate the relationship between signing contracts for family doctors and home care willingness, as well as the interaction effect of functional limitations in this relationship.

The potential correlations between cell-free extracts from grown under low-oxygen conditions and volatile organic compounds in Chinese-style sausage.

Limited research has explored the use of cell-free extracts (RCFE) in meat processing. To examine the potential application of RCFE in improving the flavor quality of Chinese-style sausage, in this study, we investigated the effects and mechanisms of RCFE grown under low-oxygen conditions on the flavor development of Chinese-style sausage, using GC-MS and 4D label-free proteomics. The GC-MS analysis detected 60 volatile organic compounds, with significant increases in acids, esters, and alcohols following the addition of RCFE ( < 0.

Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus by occupying heat shock protein 90 alpha.

Background: Oral lichen planus (OLP) is a common chronic inflammatory disease with the potential of malignant transformation. Hydroxychloroquine (HCQ), derived from quinine originating from Cinchona spp. bark, is a commonly prescribed off-label for OLP.

Ultra-Thin Highly Sensitive Electronic Skin for Temperature Monitoring.

Electronic skin capable of reliable monitoring of human skin temperature is crucial for the advancement of non-invasive clinical biomonitoring, disease diagnosis, and health surveillance. Ultra-thin temperature sensors, with excellent mechanical flexibility and robustness, can conformably adhere to uneven skin surfaces, making them ideal candidates. However, achieving high sensitivity often demands sacrificing flexibility, rendering the development of temperature sensors combining both qualities a challenging task.

Shedding Light on the Aftermath: Childhood Maltreatment's Role in Modifying the Association Between Recent Life Stress and Resting-State Network Connectivity.

Childhood maltreatment has been demonstrated to impact brain development. However, whether childhood maltreatment can influence the effects of recent stress on brain networks remains unclear. This study aimed to investigate whether childhood maltreatment moderates the longitudinal relationship between recent life stress and within- and between-network connectivity in key brain networks, including the anterior salience (ASN), central executive (CEN), default mode (DMN), and emotional regulation network (ERN).

A Flexible Multifunctional Sensor Based on an AgNW@ZnONR Composite Material.

A multifunctional sensor comprising flexible and transparent ultraviolet (UV) photodetectors (PDs) with strain gauges based on Ag nanowire (AgNW)@ZnO nanorods (ZnONRs) was fabricated using a cost-effective, simple, and efficient method. High-aspect ratio silver nanowires were synthesized using the polyol method. An AgNW@ZnONR composite was formed via the hydrothermal method to ensure the multifunctional capability of the flexible sensors.

Cutting-Edge Perovskite-Based Flexible Pressure Sensors Made Possible by Piezoelectric Innovation.

In the area of flexible electronics, pressure sensors are a widely utilized variety of flexible electronics that are both indispensable and prevalent. The importance of pressure sensors in various fields is currently increasing, leading to the exploration of materials with unique structural and piezoelectric properties. Perovskite-based materials are ideal for use as flexible pressure sensors (FPSs) due to their flexibility, chemical composition, strain tolerance, high piezoelectric and piezoresistive properties, and potential integration with other technologies.

Design and Research of the Grasping Force Feedback Mechanism of Flexible Surgical Robots.

Background: Robot-assisted microsurgery (RAMS) is gradually becoming the preferred method for some delicate surgical procedures. However, the lack of haptic feedback reduces the safety of the surgery. Surgeons are unable to feel the grasping force between surgical instruments and the patient's tissues, which can easily lead to grasping failure or tissue damage.

Insights into the Understanding of the Nickel-Based Pre-Catalyst Effect on Urea Oxidation Reaction Activity.

Nickel-based catalysts are regarded as the most excellent urea oxidation reaction (UOR) catalysts in alkaline media. Whatever kind of nickel-based catalysts is utilized to catalyze UOR, it is widely believed that the in situ-formed Ni moieties are the true active sites and the as-utilized nickel-based catalysts just serve as pre-catalysts. Digging the pre-catalyst effect on the activity of Ni moieties helps to better design nickel-based catalysts.

Integrating Molecular Biology and Network Pharmacology to Analyze the Antidepressant Mechanism of Glycyrrhizaglabra.

Introduction: Antidepressants have adverse effects and induce drug resistance when used excessively or frequently. Therefore, adjuvants are needed to reduce the use of antidepressants during treatment. Traditional Chinese medicine (TCM) is an important adjunctive approach to depression with safety, environmental protection, and low toxicity.

OVAR-BPnet: A General Pulse Wave Deep Learning Approach for Cuffless Blood Pressure Measurement.

Pulse wave analysis, a non-invasive and cuff-less approach, holds promise for blood pressure (BP) measurement in precision medicine. In recent years, pulse wave learning for BP estimation has undergone extensive scrutiny. However, prevailing methods still encounter challenges in grasping comprehensive features from pulse waves and generalizing these insights for precise BP estimation.

Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.

Aim: Autophagy is involved in human apical periodontitis (AP). However, it is not clear whether autophagy is protective or destructive in bone loss via the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) axis. This study aimed to investigate the involvement of autophagy via the RANKL/RANK/OPG axis during the development of AP in an experimental rat model.

Single-cell RNA sequencing identifies interferon-inducible monocytes/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk.

Aims: Abdominal aortic aneurysm (AAA) represents a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Nevertheless, knowledge regarding changes in regulators associated with aortic status remains incomplete. A thorough understanding of cell types and signalling pathways involved in the development and progression of AAAs is essential for the development of medical therapy.

Fractionated irradiation induces radioresistant oral carcinoma cells with enhanced malignant phenotypes.

Objective: The fact that certain oral carcinoma patients experience radiotherapy failure implies that a more radioresistant and aggressive phenotype of surviving cancer cells potentially occurs during treatment. Our study aimed to establish radioresistant oral cancer cells through a fractionated irradiation protocol that mimics clinically relevant radiotherapy dosing strategies and to investigate all-round alterations in the malignant phenotype.

Methods: Radioresistant oral carcinoma cells were generated by exposing Cal27 and Detroit 562 cells to 60 Gy radiation in 10 dose-escalating fractions and verified by cell immunofluorescence.