Publications by authors named "JingJing Lin"

Background: The responses of the infant gut microbiota to infection significantly disrupt the natural intrahost evolutionary processes of the microbiome. Here, we collected a 16-month longitudinal cohort of infant gut microbiomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Then, we developed a multicriteria approach to identify core interaction network driving community dynamics under environmental disturbances, which we termed the Conserved Variated Interaction Group (CVIgroup).

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Objective: Comorbid pain and depression are common but remain difficult to treat. Electroacupuncture (EA) can effectively improve symptoms of depression and relieve pain, but its neural mechanism remains unclear. Therefore, we used resting-state functional magnetic resonance imaging (rs-fMRI) to detect cerebral changes after initiating a mouse pain model via constriction of the infraorbital nerve (CION) and then treating these animals with EA.

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Background: Ultraviolet B (UVB) irradiation can damage skin tissue. Diabetes aggravates skin lesions. Fibroblast growth factor 21 (FGF21) is significantly involved in exerting protective effects and facilitating tissue repair.

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The rising threat of antimicrobial-resistant (AMR) infections highlights the urgent need for effective antimicrobial agents and therapies. Peptide-based antimicrobial nanomaterials are well-placed to meet this need. Here, we explore the conjugation of antimicrobial gemini quaternary ammonium compounds (GQAs) with designed short hexapeptides to create cationic antimicrobial nanomaterials with low cytotoxicity and minimal resistance tendency.

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Article Synopsis
  • Oxidative stress is a key factor in neurodegenerative diseases by damaging neurons, making the reduction of reactive oxygen species (ROS) a potential treatment approach.
  • Fibroblast growth factor 21 (FGF21) has shown protective effects on neuronal cells, as it can enhance cell viability by reducing mitochondrial apoptosis and lowering ROS levels.
  • The research indicates that treatment with rhFGF21 increases the expression of p-AKT, which plays a critical role in mediating cell survival against oxidative stress, suggesting that FGF21's protective effects are linked to the AKT and ROS signaling pathway.
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Infections caused by persistent, drug-resistant bacteria pose significant challenges in inflammation treatment, often leading to severe morbidity and mortality. Herein, the photosensitizer rhodamine derivatives are selected as the light-trapping dye and the electron-rich substituent N-nitrosoaminophen as the nitric oxide (NO)-releasing component to develop a multifunctional (deep) red-light activatable NO photocage/photodynamic prodrug for efficient treatment of wounds and diabetic foot infections. The prodrug, RhB-NO-2 integrates antimicrobial photodynamic therapy (aPDT), NO sterilization, and NO-mediated anti-inflammatory properties within a small organic molecule and is capable of releasing NO and generating Reactive oxygen species (ROS) when exposed to (deep) red laser (660 nm).

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Single treatment methods for wound infections caused by drug-resistant bacteria often fail to simultaneously achieve high antimicrobial efficacy and wound healing efficiency. Therefore, it is crucial to develop a small molecule prodrug that can achieve both goals, in this context, we have engineered a green-light-activated nitric oxide photocage/photodynamic therapeutic prodrug, designed to release NO, which not only potentiates antimicrobial efficacy but also facilitates collagen accumulation at the wound interface, thereby expediting the wound healing process. Additionally, it mitigates tissue inflammation by suppressing the NF-κB signaling pathway.

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Background: To evaluate the safety and efficacy of low-dose roxadustat combined with low-dose recombinant human erythropoietin (rhEPO) for the treatment of renal anemia in hemodialysis patients.

Materials And Methods: We retrospectively reviewed the medical records of hemodialysis patients with moderate renal anemia between December 2019 and July 2023 from two medical centers. Patients were classified into 3 groups: rhEPO (150 - 300 IU/kg/week), roxadustat (1.

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Hypergraph Neural Networks (HGNNs) have been significantly successful in higher-order tasks. However, recent study have shown that they are also vulnerable to adversarial attacks like Graph Neural Networks. Attackers fool HGNNs by modifying node links in hypergraphs.

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Rabs are involved in neuronal development and protrusion formation. Existing studies support the notion that manipulation or mutation of Rab genes could lead to functional changes in neurons. However, whether Rabs gene-manipulation induced Drosophila eye-degeneration remains unknown.

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Article Synopsis
  • The study explored the functional connectivity (FC) of the anterior and posterior hypothalamus with the whole brain in patients with insomnia disorder (ID) and examined how these values relate to serum levels of neurotransmitters that promote arousal, specifically orexin-A and histamine.
  • It included 30 ID patients and 30 healthy controls, using resting-state functional magnetic resonance imaging (RS-fMRI) to measure FC and enzyme-linked immunosorbent assay (ELISA) to determine serum concentrations of the neurotransmitters.
  • Results showed decreased FC in specific brain regions among ID patients compared to healthy controls, along with higher levels of orexin-A and histamine; a correlation was found between FC in certain areas and
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Cell metabolism, as the key driver of inflammation, revascularization and even subsequent tissue regeneration, is controlled by and also conversely influenced by signal transduction. Incorporation of cell metabolism into tissue engineering research holds immense potential for in-situ treatment repair and further understanding of the host-biomaterial cues in body response. In this study, an anti-inflammatory waterborne polyurethane scaffold incorporated with poly-l-lactic acid (PLLA) block was served to repair nerve injuries (LAx-WPU).

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Article Synopsis
  • - The study aimed to assess how Ligustrazine (Lig) affects migraines triggered by nitroglycerin and to investigate the mechanisms involved, particularly focusing on the mitochondria-inflammation pathway.
  • - Using rat models, researchers divided subjects into different treatment groups and measured various factors including pain thresholds, mitochondrial health, and levels of inflammatory markers, revealing that Lig improved outcomes compared to a control group.
  • - Results indicated that Lig has anti-migraine effects by reducing inflammation and oxidative stress related to mitochondrial function, highlighting its potential for future migraine treatment strategies.
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Article Synopsis
  • * Researchers examined 231 patients and found that 31 had ST-1, with 80.6% of them carrying the c.544A>G mutation; they identified other NEU1 variants, including two novel ones.
  • * The study concluded that ST-1 should be considered in Southeastern Chinese patients exhibiting PMA or ataxia symptoms, suggesting that genetic testing for the NEU1 c.544A>G mutation could be a key diagnostic
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Background: Low peak expiratory flow (PEF) rate is common in patients with stroke. Studies on changes in PEF rates in patients with stroke often have small sample sizes, limiting the generalizability of their findings.

Aim: This study aimed to compare the PEF rates between patients who were post-stroke with or without pneumonia and age- and sex-matched healthy controls and explore the PEF-pneumonia association among stroke survivors.

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Background: The present study explored the serum glutamate (Glu), glutamine (Gln), glutamic acid dehydrogenase (GAD) concentrations and the mRNA expression levels of the N-methyl-D-aspartate receptor (NMDAR) NR1 subunit in the peripheral blood of patients with insomnia disorder (ID). To our knowledge, this is the first study showing an increase in the mRNA expression levels of the NMDAR NR1 subunit in patients with ID.

Methods: This study included 30 ID patients and 30 matched healthy controls.

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Background: Self-efficacy and health literacy are closely related to the quality of life in patients with chronic diseases; however, it remains unclear whether their combined effects on the quality of life (QoL) in these patients operate through mediation, interaction, or a combination of both.

Methods: The research occurred in China between July 10 and September 15, 2021. A multi-stage random sampling technique was utilized to gather information on self-efficacy, health literacy, and QoL among individuals with chronic diseases.

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Article Synopsis
  • Scientists are working on creating special materials called scaffolds that can help the body heal tissues better by responding to the body's mechanical signals.
  • They figured out a way to change how stiff or soft these materials are using water-based substances that break apart and fit together differently.
  • In tests, these new materials helped brain cells grow and heal with less inflammation, showing how they could be used in medicine to create better healing tools for the body.
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Objective: This study aims to investigate the occurrence of postoperative kinesiophobia in patients with CSM and compare the postoperative recovery of patients with and without kinesiophobia to understand its influence on clinical outcomes in CSM.

Methods: Between November 2020 and November 2022, surgical treatment was performed in the neurosurgical wards of 2 Grade III Class A general public hospitals in the Fujian Province. The demographic and disease data of the patients were collected, and patients were divided into a kinesiophobia group and non-kinesiophobia group according to the Tampa kinesiophobia Scale (TSK).

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With the exponential growth in data density and user ends of wireless networks, fronthaul is tasked with supporting aggregate bandwidths exceeding thousands of gigahertz while accommodating high-order modulation formats. However, it must address the bandwidth and noise limitations imposed by optical links and devices in a cost-efficient manner. Here we demonstrate a high-fidelity fronthaul system enabled by self-homodyne digital-analog radio-over-fiber superchannels, using a broadband electro-optic comb and uncoupled multicore fiber.

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Objective: This study aimed to compare the effects of patient-controlled intravenous analgesia (PCIA) with and without low-basal infusion on postoperative hypoxaemia.

Design: A randomised parallel-group non-inferiority trial.

Setting: The trial was conducted at a grade-A tertiary hospital from December 2021 to August 2022.

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Background: To analyze the vessel density (VD) of the retina and choriocapillaris (CC) layer and the structure of the foveal avascular zone (FAZ) in the fellow eyes of central serous chorioretinopathy (CSC) patients by using optical coherence tomography angiography (OCTA).

Methods: This was a case-control study. Unilateral CSC patients and age-matched healthy subjects were recruited from the Affiliated Eye Hospital of Wenzhou Medical University between July 2016 and July 2021.

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Objective: Most paroxysmal kinesigenic dyskinesia (PKD) cases are hereditary, yet approximately 60% of patients remain genetically undiagnosed. We undertook the present study to uncover the genetic basis for undiagnosed PKD patients.

Methods: Whole-exome sequencing was performed for 106 PRRT2-negative PKD probands.

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As the optical communication industry advances, metropolitan area networks (MANs) and radio access networks (RANs) are extensively deployed on a large scale, demanding energy-efficient integrated light sources and simplified digital signal processing (DSP) technologies. The emergence of thin-film lithium niobate (TFLN) has given rise to high-performance, energy-efficient on-chip modulators, making on-chip optical frequency comb (OFC) more appealing. Owing to the phase uniformity and stability of this chip-scale device, it has been possible to eliminate the carrier frequency phase estimation (CPE) in DSP stacks using comb-clone-enabled self-homodyne detection.

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