Recently, interface scattering and low mobility have significantly impeded the performance of two-dimensional (2D) P-type transistors. 2D semiconductor tellurium (Te) has garnered significant interest owing to its unique atomic chain crystal structure, which confers ultrahigh hole mobility. van der Waals heterojunction enhances transistor performance by reducing scattering at the gate-channel interface, attributed to its high-quality interface.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) represents a major risk factor of ischemic stroke recurrence with serious management implications. However, it often remains undiagnosed due to lack of standard or prolonged cardiac rhythm monitoring. We aim to create a novel end-to-end artificial intelligence (AI) model that uses MRI data to rapidly identify high AF risk in patients who suffer from an acute ischemic stroke.
View Article and Find Full Text PDFBackground: Post-myocardial infarction ventricular arrhythmias are a leading cause of sudden cardiac death (SCD) following acute myocardial infarction worldwide. Emerging evidence suggests that ferroptosis, an iron-dependent form of cell death, plays a significant role in myocardial infarction damage. While mitochondrial ferritin (FtMt) is known to encapsulate harmful ferrous ions within mitochondria, its role in the development of post-myocardial infarction ventricular arrhythmias (post-MI VAs) is not well understood.
View Article and Find Full Text PDFHere, we propose a blind signal reconstruction scheme for continuous-time photonic time stretch (CT-PTS) analog-to-digital converters (ADCs). The dynamic envelope extraction is realized online through low-pass filtering avoiding the effect of system parameter fluctuation. Channel mismatch is blindly corrected by processing the overlapping segments between adjacent channels using the least mean squares algorithm.
View Article and Find Full Text PDFTaking advantage of their unparalleled electrostatic and optoelectronic properties, 2D layered materials (2DLMs) have emerged as alluring building blocks for crafting advanced photodetectors. Nevertheless, preceding research has predominantly concentrated on rudimentary designs incorporating single-channel or single-junction setups, failing to exert the full potency of 2DLMs. Therefore, there is still an imperative requirement to develop innovative device architectures grounded in novel physical mechanisms.
View Article and Find Full Text PDFSoluble dietary fiber, notably as an adjunct to early enteral nutrition (EEN), is gaining prominence in clinical therapy. This study evaluates the effect of fructooligosaccharides (FOS), a new soluble dietary fiber, on the prognosis of patients with severe acute pancreatitis (SAP). In a retrospective cohort study at the Third Xiangya Hospital of Central South University from July 2017 to July 2023, 110 SAP patients were analyzed.
View Article and Find Full Text PDFPolarimetric imaging and encryption improve target recognition precision and information security, enhancing image sensors' perceptual acuity and interference resilience. However, the miniaturization of sensing systems faces challenges due to the complex integration of dispersive optical components such as polarizers. To address this, we propose a polarization-sensitive photodetector using a Te/ReSe van der Waals heterostructure.
View Article and Find Full Text PDFBackground: This study investigates the relationship between basal metabolic rate (BMR), body composition, obesity indices, and cognitive impairment (CI) in middle-aged and older type 2 diabetes mellitus (T2DM) patients, assessing their potential role in CI screening.
Methods: A cross-sectional study included 1243 T2DM patients over 45 years old. CI was assessed using the Montreal Cognitive Assessment.
Background: The role of solute carrier family 6 member 17 (SLC6A17) in lung adenocarcinoma (LUAD) is unclear.
Objectives: To address this gap in knowledge, we employed bioinformatics analysis and experimental validation.
Methods: This research aimed to scrutinize the expression patterns of the SLC6A17 gene across a spectrum of cancers and specifically within LUAD, utilizing data extracted from The Cancer Genome Atlas (TCGA).
Background: Obesity and insulin resistance (IR) may be risk factors for thyroid disease, but there is no clinical-based consensus on this topic. Therefore, this study aims to evaluate the associations between the triglyceride-glucose index (TyG) and its derivatives and Hashimoto thyroiditis (HT) in type 2 diabetes mellitus (T2DM) patients, and explore the relationships between the central obesity indicators and HT risk to provide a reliable basis for the early prevention of HT.
Methods: A total of 1071 T2DM patients aged ≥ 20 years were selected from a tertiary hospital in Tianjin, all of them had normal thyroid function (including free triiodothyronine, free thyroxine, total triiodothyronine, total thyroxine, and thyroid-stimulating hormone).
Proc Natl Acad Sci U S A
December 2024
The origins of rice domestication and the beginnings of alcoholic fermentation in China are intriguing research topics, with the Shangshan culture in the Lower Yangzi River region being a focal point of archaeological investigations. This study employs a multiproxy approach (phytolith, starch, and fungi) to analyze microfossil remains associated with pottery vessels from the earliest phase of the Shangshan site (ca. 10,000 to 9,000 cal.
View Article and Find Full Text PDFDendrite growth in solid-state sodium batteries (SSBs) is one of the most concerned issues that critically affect the battery efficiency and cycling performance. Here, by designing a fluorescent Eu-doped NaZrSiPO solid electrolyte (SE) to facilitate three-dimensional (3D) optical imaging on a confocal laser scanning microscopy, a fluorescence tomography (FT) method is developed for observing the sodium dendrite growth during charge/discharge cycles of the SSBs in a 3D view. It is quantitatively revealed that small-size sodium islands appear after several cycles, and with the cycles increasing, large-size dendrites in tens of micrometers gradually form until a critical sodium dendrite volume arrives where a short circuit or severe performance deterioration occurs.
View Article and Find Full Text PDFACS Appl Mater Interfaces
November 2024
With the continuous advancement of intelligent vehicle technology, automatic obstacle avoidance (AOA) has become a crucial component of in-vehicle systems. This study introduces an AOA trolley system based on ReS/WSe heterojunction photodetectors. The device with type-II band alignment exhibits an impressive on/off current ratio of 7.
View Article and Find Full Text PDFObjective: This study investigated the association of Time In Range (TIR) obtained from Blood Glucose Monitoring (BGM) with Cognitive Impairment (CI) inpatients with middle-aged Type 2 Diabetes Mellitus (T2DM) and further explored whether a TIR goal for T2DM in adults with > 70% possess a protective effect on cognitive function.
Research Design And Methods: A total of 274 inpatients with T2DM aged 40-64 years, who underwent seven-point BGM ( pre meals and 120 min post meals and at bedtime) were recruited in this cross-sectional study. TIR was defined as the percentage of blood glucose within the target range of 3.
Producing hydrogen via seawater electrolysis is pivotal for addressing both energy and environmental crises. An industrial-current-density electrocatalyst consisting of Mo-doped FeCoP nanorods decorated with MnO nanosheets is elaborately designed and grows in situ on nickel foam forming hierarchical Mo-FeCoP@MnO/NF (M-FCP@MnO/NF) for seawater electrolysis. Density functional theory calculations demonstrate that MnO species remarkably reduce the adsorption capacity of Cl, which enhances the corrosion resistance and selectivity of M-FCP@MnO/NF during seawater electrolysis.
View Article and Find Full Text PDFLeukemia is a cancer that starts in blood stem cells in the bone marrow. Today, the proper diagnosis and prognosis of leukemia are essential in mitigating the morbidity and mortality associated with this malignancy. The advent of novel biomarkers, particularly those related to minimal residual disease, has paved the way for personalized therapeutic strategies and enables the quantitative assessment of patient responses to treatment regimens.
View Article and Find Full Text PDFInsect herbivores adapt and develop strategies to counteract plant chemical defenses. The aphid Uroleucon formosanum is a serious sap-sucking pest that infests lettuces containing toxic sesquiterpene lactones (STLs). Herein, we employed a combination of genome sequencing and RNA-seq transcriptome profiling to understand the mechanisms underlying phytotoxin tolerance in U.
View Article and Find Full Text PDFThe machine vision utilized in unmanned driving systems must possess the ability to accurately perceive scenes under low-light illumination conditions. To achieve this, photodetectors with low detection limits and a fast response are essential. Current systems rely on avalanche diodes or lidars, which come with the drawbacks of increased energy consumption and complexity.
View Article and Find Full Text PDFBMC Public Health
September 2024
Background: Numerous reports indicate that both obesity and type 2 diabetes mellitus (T2DM) are factors associated with cognitive impairment (CI). The objective was to assess the relationship between abdominal obesity as measured by waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and CI in middle-aged and elderly patients with T2DM.
Methods: A cross-sectional study was conducted, in which a total of 1154 patients with T2DM aged ≥ 40 years were included.
Islet transplantation has been developed as an effective cell therapy strategy to treat the progressive life-threatening disease Type 1 diabetes (T1DM). To mimic the natural islets and achieve immune isolation, hydrogel encapsulation of multiple islet cell types is the current endeavor. Here, we present a microfiber loading with pancreatic α and β cells by microfluidic spinning for diabetes treatment.
View Article and Find Full Text PDFThe islet of Langerhans, functioning as a "mini organ", plays a vital role in regulating endocrine activities due to its intricate structure. Dysfunction in these islets is closely associated with the development of diabetes mellitus (DM). To offer valuable insights for DM research and treatment, various approaches have been proposed to create artificial islets or islet organoids with high similarity to natural islets, under the collaborative effort of biologists, clinical physicians, and biomedical engineers.
View Article and Find Full Text PDFBackground: The objective of this study is to investigate the incidence, potential risk factors, and clinical outcomes of incomplete device endothelialization (IDE) in atrial fibrillation (AF) patients undergoing Watchman left atrial appendage closure (LAAC).
Methods: In this study, 68 AF patients who underwent successful implantation of the Watchman device without peri-device leak (PDL) during follow-up were included. The endothelialization status was assessed using Transesophageal echocardiography (TEE) and LAA computed tomography angiography (CTA) at 6 weeks and 6 months post-implantation.
Multi-component synergy and the rational design of structures are effective methods for preparing electrode materials for high-performance energy storage devices. Transition metal-based hydroxides offer advantages such as a large specific surface area, large interlayer spacing, multiple redox states, and high theoretical capacity, making them commonly used as positive materials for supercapacitors. However, challenges like low conductivity and severe agglomeration limit their practical application.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2024
Two-dimensional (2D) van der Waals heterostructures that embody the electronic characteristics of each constituent material have found extensive applications. Alloy engineering further enables the modulation of the electronic properties in these structures. Consequently, we envisage the construction and modulation of composition-dependent antiambipolar transistors (AATs) using van der Waals heterostructures and alloy engineering to advance multivalued inverters.
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