Two-Fold Genes, Three-Fold Control Regions, lncRNA, and the "Missing" Found in the Mitogenomes of (Rhacophridae: ).

In prior research on the mitochondrial genome (mitogenome) of , the one copy of gene was translocated to the control region (CR) and the gene was not found. Gene loss is uncommon among vertebrates. However, in this study, we resequenced the mitogenomes of from different regions using a "primer bridging" approach with Sanger sequencing technologies, which revealed the "missing" gene in as well as three other previously published .

Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in C57BL/6J mice skin.

Purpose: The active melanocytes in the skin were affected by hormones and ultraviolet (UV) irradiation. Licorice zinc has a whitening effect, which may have a prominent potential in the treatment of pigmented skin disease.

Methods: Modeling chloasma C57BL/6J mice by daily progesterone injection (15 mg/kg) and ultraviolet B (UVB) irradiation (λ = 312 nm, 2 h/day) for 30 days.

[Preparation and characterization of near-infrared responsive sinomenine hydrochloride reservoir microneedles].

The present study designed and prepared near-infrared responsive sinomenine hydrochloride(SIN) reservoir microneedles and evaluated the feasibility of this type of microneedles in increasing the drug loading and transdermal absorption by characterizing their mechanical properties and in vitro release characteristics.SIN was selected as the model drug, and methoxy poly(ethylene glycol) poly(caprolactone)(mPEG-PCL) copolymers and indocyanine green(ICG) were employed as amphiphilic block copolymers and light inductor to prepare near-infrared responsive nanoparticles.Based on the preparation principle of bubble microneedles, near-infrared responsive SIN reservoir microneedles were designed and prepared.

[Enhancing effect and mechanism of muscone on transdermal penetration of traditional Chinese medicine ingredients with different log P value].

This study aimed to investigate the enhancing effect of muscone on the transdermal penetration of traditional Chinese medicine ingredients and explore its possible mechanism of action. The Franz diffusion cells were employed to investigate the effect of muscone on the transdermal permeation of a series of model drugs with a wide range of log P values. The solubilities at saturation and the stratum corneum(SC)/vehicle partition coefficients of model drugs were measured to evaluate the effect of muscone on drug thermodynamic activities and partition of drugs into SC.

Management and implementation strategies of pre-screening triage in children during coronavirus disease 2019 pandemic in Guangzhou, China.

Background: Emerging infectious diseases are a constant threat to the public's health and health care systems around the world. Coronavirus disease 2019 (COVID-2019), which was defined by the World Health Organization as pandemic, has rapidly emerged as a global health threat. Outbreak evolution and prevention of international implications require substantial flexibility of frontline health care facilities in their response.

Transbrachial Access for Transcatheter Closure of Paravalvular Leak Following Prosthetic Valve Replacement.

Transcatheter closure of paravalvular leak (PVL) has evolved into an alternative to surgery in high-risk patients. In this study, we introduce a new access for transcatheter closure of PVL and seek to evaluate the feasibility and safety of this access. We retrospectively analyzed patients undergoing transbrachial access for transcatheter mitral or aortic PVL closure (August 2017-November 2019) at our hospital.

[Preparation of compound liquorice microemulsion gel and its pharmacodynamics evaluation].

Based on the previous study of compound liquorice microemulsion, this paper aims to prepare the compound liquorice microemulsion gel and investigate its pharmacodynamics of chronic eczema. The type, dosage and adding method of gel matrix, and formula dosage of humectant were optimized by single factor method to obtain the formula and preparation technique of the gel. With glycyrrhizic acid, glycyrrhetin and oxymatrine used as evaluation indexes, the Franz diffusion cell method was adopted to monitor the in vitro release profile of the gel.

Ectopic expression of an AGAMOUS homologue gene in Jatropha curcas causes early flowering and heterostylous phenotypes.

Jatropha curcasseeds are abundant in biodiesel, and low seed yields are linked to poor quality female flowers, which creates a bottleneck for Jatropha seed utilization. Therefore, identifying the genes associated with flowering is crucial for the genetic enrichment of seed yields. Here, we identified an AGAMOUS homologue gene (JcAG) from J.

Query-Specific Deep Embedding of Content-Rich Network.

In this paper, we propose to embed a content-rich network for the purpose of similarity searching for a query node. In this network, besides the information of the nodes and edges, we also have the content of each node. We use the convolutional neural network (CNN) to represent the content of each node and then use the graph convolutional network (GCN) to further represent the node by merging the representations of its neighboring nodes.

Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models.

Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in has led to a need for the development of new antimalarials.

Iterative Deep Neighborhood: A Deep Learning Model Which Involves Both Input Data Points and Their Neighbors.

Deep learning models, such as deep convolutional neural network and deep long-short term memory model, have achieved great successes in many pattern classification applications over shadow machine learning models with hand-crafted features. The main reason is the ability of deep learning models to automatically extract hierarchical features from massive data by multiple layers of neurons. However, in many other situations, existing deep learning models still cannot gain satisfying results due to the limitation of the inputs of models.

De novo transcriptome assembly for the five major organs of Zanthoxylum armatum and the identification of genes involved in terpenoid compound and fatty acid metabolism.

Background: Zanthoxylum armatum (Z. armatum) is a highly economically important tree that presents a special numbing taste. However, the underlying regulatory mechanism of the numbing taste remains poorly understood.

Learning Domain-Independent Deep Representations by Mutual Information Minimization.

Domain transfer learning aims to learn common data representations from a source domain and a target domain so that the source domain data can help the classification of the target domain. Conventional transfer representation learning imposes the distributions of source and target domain representations to be similar, which heavily relies on the characterization of the distributions of domains and the distribution matching criteria. In this paper, we proposed a novel framework for domain transfer representation learning.

Low-Rank Deep Convolutional Neural Network for Multitask Learning.

In this paper, we propose a novel multitask learning method based on the deep convolutional network. The proposed deep network has four convolutional layers, three max-pooling layers, and two parallel fully connected layers. To adjust the deep network to multitask learning problem, we propose to learn a low-rank deep network so that the relation among different tasks can be explored.

Radiosynthesis and Preliminary Biological Evaluation of F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging.

Purposes: Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma. In this work, radiosynthesis of [F]-fluoropropionyl-chlorotoxin ([F]-FP-chlorotoxin) as a novel PET tracer was investigated, and biodistribution in vivo and PET imaging were performed in the C6 glioma model.

Procedures: [F]-FP-chlorotoxin was prepared from the reaction of chlorotoxin with [F]-NFB (4-nitrophenyl 2-[F]-fluoropropionate), which was synthesized from multistep reactions.

Comparative analysis of the diffusion kurtosis imaging and diffusion tensor imaging in grading gliomas, predicting tumour cell proliferation and IDH-1 gene mutation status.

Introduction: Few studies have applied diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) for the comprehensive assessment of gliomas [tumour grade, isocitrate dehydrogenase-1 (IDH-1) mutation status and tumour proliferation rate (Ki-67)]. This study describes the efficacy of DKI and DTI to comprehensively evaluate gliomas, compares their results.

Methods: Fifty-two patients (18 females; median age, 47.

Quantitative analysis of neurite orientation dispersion and density imaging in grading gliomas and detecting gene mutation status.

Background And Purpose: Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique that has rarely been applied for glioma grading. The purpose of this study was to quantitatively evaluate the diagnostic efficiency of NODDI in tumour parenchyma (TP) and peritumoural area (PT) for grading gliomas and detecting isocitrate dehydrogenase-1 () mutation status.

Methods: Forty-two patients (male: 23, female: 19, mean age: 44.

A study of neurite orientation dispersion and density imaging in wilson's disease.

Background: Previous studies have indicated that neurite orientation dispersion and density imaging (NODDI) could be used as a biomarker for detecting microstructural changes of brain.

Purpose: To quantitatively evaluate the changes in basal ganglia (BG) and thalamus in Wilson's disease (WD) by NODDI and assess the correlation between parameters and disease severity.

Study Type: Prospective case-control study.