Characteristics of amino acid metabolism in preterm infants in Guangxi, China.

Objectives: To study the characteristics of amino acid metabolism in preterm infants in Guangxi, China.

Methods: A retrospective analysis was performed on the medical data of 30 757 neonates who underwent the screening for inherited metabolic diseases and had negative results in Guangxi Neonatal Disease Screening Center from 2018 to 2020. Among these neonates, there were 28 611 normal full-term infants (control group) and 2 146 preterm infants (preterm birth group).

[Prevalence of hypertension and relationship between hypertension and obesity in children and adolescents in Nanning of Guangxi Province].

Objective: To investigate the prevalence of hypertension and the relationship between hypertension and obesity in children and adolescents aged 6-18 years in Nanning, Guangxi Province, China.

Methods: A stratified cluster random sampling method was adopted in Nanning to select 7 893 children and adolescents aged 6-18 years as research subjects. Questionnaire surveys were conducted, and blood pressure, height, weight, and other indicators of growth and development were measured.

[Pulmonary surfactant associated gene variants in mixed ethnic population of Han and Zhuang].

Objective: To explore the prevalence of pulmonary surfactant associated pathway genes functional variants in Chinese population.

Method: Using a cohort of 258 mixed ethnic population of Han and Zhuang, we pooled DNA samples from 146 term male infants and 112 term female infants and then used an Ill umina next generation sequencing platform to perform the complete exonic resequencing in 6 target genes:surfactant protein-B (SFTPB), surfactant protein-C (SFTPC), ATP-binding cassette transporter A3 (ABCA3), lysophospholipid acyltransferase 1 (LPCAT1), choline phosphotransferase 1 (CHPT1), phosphate cytidylyltransferase 1, choline, beta (PCYT1B). Collapsing methods was used to determine the functional allele frequency.

[Epidemiological study on the association between obesity with metabolic syndrome in obese children and adolescents of Nanning city, Guangxi].

Objective: To investigate the association between obesity and prevalence of metabolic syndrome (MS) with its associated risk factors, in children and adolescents.

Methods: A stratified random sampling method was used to select 7893 students from 6 to 18 years of age from 14 out of 396 primary and secondary schools in Nanning city. All the students had undergone physical examination and blood tests including the following risk factors related to metabolic syndrome: fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine amino shift enzyme (ALT), aspartic acid amine shift enzyme (AST) and fasting insulin (FINS).

[Relationship between alanine aminotransferase and overweight or obesity in children].

Objective: To study the association of alanine aminotransferase (ALT) with overweight or obesity in children.

Methods: A total of 2889 healthy children and 702 overweight or obese children aged from 7 to 18 years who had received a physical examination were enrolled. Height, body weight, waist circumference, and blood pressure were measured, and the biochemical indicators including blood glucose, blood lipids, ALT, and insulin were detected.