Publications by authors named "Jing-shu Xiong"
Article Synopsis
- This study explores cutaneous tuberculosis, focusing on its various types and the unclear causes behind the disease.
- Researchers analyzed 58 isolated strains over 20 years, looking into their genomic traits, including lineage, drug resistance, and mutations linked to infection sites.
- Results revealed that while strains from skin and lung tuberculosis were genetically similar and showed lower drug resistance in skin cases, specific gene mutations correlated strongly with infection sites, indicating more research on these SNPs is needed.
Background: A number of studies have demonstrated that N6-methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma. However, the relationship between m6A readers such as YTH domain family (YTHDF) proteins and melanoma was still elusive.
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- - The study focused on a skin infection in an immunocompromised patient in China caused by a new type of bacteria from the Mycobacterium gordonae complex.
- - Whole-genome sequencing revealed that some strains previously identified as M. gordonae are actually distinct species, meaning they have different evolutionary histories.
- - The findings suggest the need for reclassification of these strains to better reflect their relationships and differences.
Background: Genome-wide association studies (GWASs) have identified some immune-related single-nucleotide polymorphisms (SNPs) to be associated with leprosy.
Methods: This study investigated the association of 17 SNPs based on previously published GWAS studies with susceptibility to leprosy, different polar forms and immune states of leprosy in a case-control study from southwestern China, including 1344 leprosy patients and 2732 household contacts (HHCs) (1908 relatives and 824 genetically unrelated contact individuals). The differences of allele distributions were analyzed using chi-squared analysis and logistic regression.
Background: There is a high incidence of leprosy among house-contacts compared with the general population. We aimed to establish a predictive model using these genetic factors along with epidemiological factors to predict leprosy risk of leprosy household contacts (HHCs).
Methods: Weighted genetic risk score (wGRS) encompassing genome wide association studies (GWAS) variants and five non-genetic factors were examined in a case-control design associated with leprosy risk including 589 cases and 647 controls from leprosy HHCs.
Background: Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoproliferative disorder has been defined as a type of lymphoproliferative disorder with indolent clinical course and excellent prognosis, yet a precise diagnosis is still hard to reach.
Methods: A retrospective analysis of 22 patients including 16 females and six males was performed.
Results: The age of patients ranged from 5 to 79 years.
Melanoma is a rare but fatal form of skin cancer and acral lentiginous melanoma (ALM) is one of its most common types. Long non-coding RNA (lncRNA) has emerged as a crucial molecule in the development and progression of human cancers, and several studies have revealed that lncRNAs may be associated with the pathogenesis, progression and metastasis of melanoma. To demonstrate the association between ALM and lncRNAs, microarray analysis was performed in tumor and adjacent non-tumor tissues.
View Article and Find Full Text PDFWe report a case of cutaneous anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALCL) with linear distributional lesions and sarcomatoid histologic features. A sarcomatoid variant is the rarest morphological pattern of ALCL. Interestingly, the morphology of tumor cells in the present case transitioned from a sarcomatoid variant of ALCL at first diagnosis to a classic variant at relapse.
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