Publications by authors named "Jing-ping Zhao"
Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned cortical vulnerability. Here, we initially examined voxel-wise differences in cortical function and structure using the largest multi-modal MRI data from 1660 MDD patients and 1341 controls.
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- The document serves to correct an earlier published article identified by DOI: 10.3389/fpsyt.2021.638773.
- It updates specific information or errors found in the original publication.
- The correction aims to enhance the clarity and accuracy of the findings presented in the original study.*
Article Synopsis
- Despite advancements in neuroimaging research on major depressive disorder (MDD), findings remain inconsistent due to small sample sizes and varying analysis methods, prompting the launch of the Depression Imaging REsearch ConsorTium (DIRECT) and the REST-meta-MDD project, which pooled data from 2,428 functional brain images.
- The initial analyses revealed significant changes in brain connectivity and dynamics, laying the groundwork for future research and highlighting the need for more comprehensive studies across diverse populations.
- DIRECT's second phase aims to broaden the investigation of brain alterations in MDD by including various ethnic groups and other mental health disorders, while also focusing on long-term studies of treatment effects and improving neuroimaging methodologies for clinical applications.
Article Synopsis
- The study investigates the nucleus accumbens (NAc), which is key in reward processing and its role in major depressive disorder (MDD).
- Through meta- and mega-analysis of resting-state fMRI data, it was found that patients with recurrent MDD exhibited decreased functional connectivity within the NAc-based reward circuits.
- The research highlights that disrupted connectivity between the reward network and the default mode network (DMN) may aid in differentiating MDD patients from healthy individuals, suggesting potential biomarkers for diagnosis.
Background: The corona virus disease 2019 (COVID-19) has been a pandemic for more than one year and estimated to affect the whole world in the near future.
Case Summary: Here we reported that one COVID-19 patient with vesicles was treated by bullectomy. The patient's perioperative laboratory tests were analyzed.
Article Synopsis
- * Researchers employed graph theory methods to analyze functional brain networks, finding that MDD patients exhibited significantly decreased global and local efficiency compared to normal controls.
- * The results highlighted specific disruptions in critical brain networks, particularly affecting recurrent MDD patients, indicating a consistent pattern of impaired efficiency in both local and global brain network communication.
Article Synopsis
- The review focuses on understanding the causes of negative symptoms and cognitive dysfunction in schizophrenia, highlighting the roles of genetics and epigenetics.
- It discusses new treatments, including novel medications and advanced therapies like transcranial magnetic stimulation, aimed at alleviating these symptoms.
- The overall goal is to enhance treatment strategies for schizophrenia, improving outcomes for patients dealing with these challenges.
Schizophrenia is a severe mental disease which characterized by positive symptom, negative symptom, general pathology syndrome and cognitive deficits. In recent years, many studies have investigated the relationship between cognitive deficits and clinical characteristics in schizophrenia, but relatively few studies have been performed on first-episode drug-naïve patients. Eighty seven first-episode drug-naïve schizophrenia patients were assessed for positive symptom, negative symptom, general pathology symptom and cognitive deficits from the Positive and Negative Symptom Scale and MATRICS Consensus Cognitive Battery.
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- Cognitive impairment is a major symptom of schizophrenia and is linked to the disorder's prognosis, with recent studies suggesting a possible connection between metabolic disorders and cognitive issues.
- The study involved 172 early-stage schizophrenia patients and assessed their metabolic parameters and cognitive function through the MATRICS Consensus Cognitive Battery (MCCB).
- Despite a high prevalence of cognitive impairment (84.7%) in this group, the analysis indicated no clear association between metabolic disorders and cognitive impairment, implying that other factors may be at play.
Article Synopsis
- The study investigates brain functional connectivity asymmetry in patients with Major Depressive Disorder (MDD) using resting-state fMRI data from 753 patients compared to 451 healthy controls.
- Results show that MDD patients exhibited increased asymmetry scores, indicating decreased specialization in various brain networks, particularly in the default mode, control, and attention networks, influenced by demographic and clinical variables.
- The findings suggest that MDD disrupts efficient brain information processing, providing new insights into the pathophysiology of depression that could inform future research.
Article Synopsis
- Major depressive disorder (MDD) is complex and can be divided into subtypes based on differences in brain connectivity within the default mode network (DMN), as revealed by a study involving 1,397 participants (690 MDD patients and 707 healthy controls).
- Researchers used advanced data analysis methods, such as K-means and principal component analysis, to identify two distinct MDD subgroups—hyperDMN MDD (increased connectivity) and hypoDMN MDD (decreased connectivity)—which were consistently observed across multiple trials.
- The discovery highlights the importance of understanding these neural subtypes, potentially guiding more personalized treatments for individuals with depression based on their specific connectivity patterns.
Importance: The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully understood.
Objective: To explore the genetic basis of BD in the Han Chinese population.
Design, Setting, And Participants: A genome-wide association study (GWAS), followed by independent replication, was conducted to identify BD risk loci in Han Chinese individuals.
Unlabelled: Weight gain and metabolic disturbances, potentially influenced by increased appetite, are common effects of olanzapine treatment in patients with schizophrenia. In this study, we explored the association between olanzapine-induced weight gain and metabolic effects with increased appetite. Drug-naïve, first-episode schizophrenia patients were treated with olanzapine for 12 weeks.
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- Researchers induced manic-like symptoms in rats using ouabain and used aspirin to treat these symptoms and the associated inflammation.
- The study found that aspirin partially reversed several mania-like behaviors and inflammatory markers in rats, suggesting it could be a potential additional treatment for BD.
Increased frontal gray matter volume in individuals with prodromal psychosis.
CNS Neurosci Ther
September 2019
Article Synopsis
- The study investigates brain anatomical deficits in individuals showing early signs of psychosis (prodromal individuals) compared to healthy controls.
- Using MRI scans, the researchers found that prodromal individuals had increased gray matter volume in certain frontal brain areas, specifically the right inferior frontal gyrus and right rectus gyrus.
- Although these increased gray matter volumes did not correlate with clinical or cognitive features, they showed potential as markers for distinguishing prodromal individuals from healthy controls, emphasizing the role of the frontal regions in psychosis development.
Article Synopsis
- Major depressive disorder (MDD) is prevalent and disabling, with unclear underlying brain mechanisms; the REST-meta-MDD Project aims to address these knowledge gaps using a large data set.
- The project involved 25 research groups in China analyzing resting-state fMRI data from 1,300 MDD patients and 1,128 normal controls, finding decreased connectivity in the default mode network (DMN) among recurrent MDD patients.
- The study highlights the importance of DMN connectivity in MDD, revealing a relationship between decreased connectivity, medication usage, and symptom severity, while encouraging further research on the impact of these findings on treatment response.
The aim of this study was first to investigate associations between maternal dietary patterns and autism spectrum disorders (ASDs) and second to investigate association between maternal supplement intake and ASD.We used a case-control study design to enroll typically developing (TD) children and children with ASD, and data were derived from the Autism Clinical and Environmental Database (ACED).Three seventy four children with AUTISM and 354 age matched TD children were included.
View Article and Find Full Text PDFA new self-rating functional scale (SRFS) was developed to assess the functionality of patients with schizophrenia, referred to the structure of Personal and Social Performance Scale (PSP). The main aim of this study was to evaluate the reliability and validity of the SRFS. A total of 210 patients with schizophrenia were recruited from outpatient clinics in six sites in China.
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- The study assessed the quality of life in Chinese parents of preschool children with autism spectrum disorder (ASD) compared to parents of typically developing (TD) children, involving 406 families with ASD and 513 with TD.
- Results showed that parents of children with ASD had a lower quality of life, particularly mothers, who reported a greater childcare burden than mothers of TD children.
- It was found that the social impairment in children with ASD negatively impacted mothers' quality of life through increased childcare burden, while fathers' experiences were not similarly affected.
Aims: Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this study, whole-brain FCS was assessed to examine the altered patterns of FCS in UHR subjects.
View Article and Find Full Text PDFAggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study.
View Article and Find Full Text PDFBackground: With attention to misdiagnosis of bipolar disorder (BP), long duration of undiagnosed bipolar disorder (DUBP) had been reported recently in years. This study aims to investigate the contributions of long DUBP to the frequency of relapse in bipolar patients, and explore affect factors of DUBP.
Method: From 26 hospitals throughout China, 3896 participants diagnosed with BP according to International Classification of Diseases 10th criteria were enrolled in this study.