Publications by authors named "Jing-min Ou"
Rationale: Primary hepatic yolk sac tumors (YSTs) are rare in adults. Liver resection is an acknowledged treatment modality for primary hepatic YST. Liver transplantation may offer a possible cure for unresectable cases.
View Article and Find Full Text PDFLower extremity arteriosclerosis obliterans (LEASO) is a vascular disease that may result in adult limb loss worldwide. CD4T cell-mediated immunity plays a significant role in LEASO. The T cell immunoglobulin and mucin domain 3 (Tim-3) and inhibitory receptor programmed cell death-1 (PD-1) are well-known immune checkpoints that play crucial roles in regulating CD4T cell activation or tolerance.
View Article and Find Full Text PDFmiR-199a-5p inhibits proliferation and induces apoptosis in hemangioma cells through targeting HIF1A.
Int J Immunopathol Pharmacol
August 2018
MicroRNAs (miRNAs) exhibit a crucial role in the regulation of angiogenesis and tumor progression, of which miR-199a-5p (miR-199a) has been reported to function as a tumor suppressor in multiple malignancies. However, the precise mechanisms underlying miR-199a in hemangiomas (HAs) remain elusive. In this study, we found that miR-199a had low expression level, while proliferating cell nuclear antigen (PCNA) had high expression level in proliferating-phase HAs compared with the involuting-phase HAs and normal tissues.
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- Endothelial injury and dysfunction, driven by factors like oxidized low-density lipoprotein (ox-LDL), contribute to the development of atherosclerosis, promoting inflammation and lipid buildup in arteries.
- Stimulation of human umbilical vein endothelial cells (HUVECs) with ox-LDL leads to increased pro-inflammatory cytokine production, cell death, and decreased migration, with an upregulation of Tim-3 expression.
- Tim-3 helps protect HUVECs from ox-LDL-induced apoptosis and promotes migration by activating the JNK pathway, suppressing inflammatory cytokines, and enhancing the production of beneficial T cell cytokines, indicating its potential therapeutic role in atherosclerosis.
Gene expression was examined in hemangiomas (HA), benign, birthmark-like tumors occurring in infancy, and confirmed in HA-derived endothelial cells (HDEC), for which cell proliferation and apoptosis were also assessed. Protein and mRNA accumulation of Rho-associated protein kinase (ROCK), vascular endothelial growth factor (VEGF), Ki-67 and proliferating cell nuclear antigen was significantly higher in proliferating phase HAs than in involuting phase HAs. In contrast, p53 and caspase-3 exhibited higher levels of accumulation in involuting than proliferating HAs.
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- T cell-mediated immunity is crucial in atherosclerosis (AS), with CD8+ T cells having a key, yet unclear, role.
- The co-expression of inhibitory receptors PD-1 and Tim-3 on CD8+ T cells is found to be increased in AS patients, particularly in a proliferative T cell subset.
- This co-expression corresponds with enhanced anti-atherogenic cytokine production and reduced pro-atherogenic cytokines, emphasizing the significance of PD-1 and Tim-3 in managing CD8+ T cell function in AS.
Article Synopsis
- The study aimed to explore how dexamethasone and Salvia miltiorrhiza can protect various organs in rats suffering from severe acute pancreatitis (SAP).
- Results indicated that dexamethasone treatment significantly reduced mortality rates, improved organ pathology, and lowered levels of harmful proteins and enzymes compared to the control group.
- Salvia miltiorrhiza also showed protective effects, but its efficacy varied for certain biomarkers, particularly in kidney function at specific time points.
Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro.
World J Gastroenterol
April 2002
Aim: To elucidate whether human primary gastric cancer and gastric mucosa epithelial cells in vitro can grow normally in a methionine (Met) depleted environment, i.e. Met-dependence, and whether Met-depleting status can enhance the killing effect of chemotherapy on gastric cancer cells.
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