Nano-alkaline ion-excited NETs ablative eye drops promote ocular surface recovery.

Neutrophil extracellular traps (NETs) promote neovascularization during the acute phase after ocular chemical injury, while the local inflammatory acidic environment delays post-injury repair. Currently, the mechanism of NETs promoting neovascularization has not been fully elucidated, and there is a lack of therapeutic strategies to effectively improve the local microenvironment for corneal repair. In this study, we validated the NETs-M2-angiogenic pathway after injury.

Identification of a broad-inhibition influenza neuraminidase antibody from pre-existing memory B cells.

Identifying broadly reactive B precursor cells and conserved epitopes is crucial for developing a universal flu vaccine. In this study, using influenza neuraminidase (NA) mutant probes, we find that human pre-existing NA-specific memory B cells (MBCs) account for ∼0.25% of total MBCs, which are heterogeneous and dominated by class-unswitched MBCs.

Exploring the spatial heterogeneity of soil organic carbon and the influence of coastal factors: A case study in the Yellow River Delta, China.

Terrestrial ecosystems have vital impacts on soil carbon sequestration, but under disturbances from anthropogenic activities, the typical indicator combinations of SOC distribution in coastal areas remain unclear. On the basis of surface soil sampling and calculations of related eco-environmental indices in the Yellow River Delta (YRD), we performed geostatistical analysis combined with Spearman's correlation analysis, principal component analysis (PCA), and hierarchical clustering analysis (HCA) to explore the spatial heterogeneity of soil organic carbon (SOC) and influential spatiotemporal factors. Overall, the results revealed that in the seaward direction of the Yellow River, the SOC concentration decreased from west to east, with a low mean value of 5.

Immobilization or mobilization of heavy metal(loid)s in lake sediment-water interface: Roles of coupled transformation between iron (oxyhydr)oxides and natural organic matter.

Iron (Fe) (oxyhydr)oxides and natural organic matter (NOM) are active substances ubiquitously found in sediments. Their coupled transformation plays a crucial role in the fate and release risk of heavy metal(loid)s (HMs) in lake sediments. Therefore, it is essential to systematically obtain relevant knowledge to elucidate their potential mechanism, and whether HMs provide immobilization or mobilization effect in this ternary system.

Improving functional correlation of quantification of interstitial lung disease by reducing the vendor difference of CT using generative adversarial network (GAN) style conversion.

Objective: To assess whether CT style conversion between different CT vendors using a routable generative adversarial network (RouteGAN) could minimize variation in ILD quantification, resulting in improved functional correlation of quantitative CT (QCT) measures.

Methods: Patients with idiopathic pulmonary fibrosis (IPF) who underwent unenhanced chest CTs with vendor A and a pulmonary function test (PFT) were retrospectively evaluated. As deep-learning based ILD quantification software was mainly developed using vendor B CT, style-converted images from vendor A to B style were generated using RouteGAN.

The association between anthropogenic heat and parent-report symptoms of childhood attention deficit hyperactivity disorder in China: A novel perspective reflecting climate change.

Anthropogenic climate change will have a negative impact on worldwide well-being over and above the direct consequences of rising average temperatures. But anthropogenic heat (AH) relationship with childhood attention deficit hyperactivity disorder (ADHD) is unknown. To assess the relationship with AH exposure and childhood ADHD symptoms in the context of global climate change, this study was conducted in a cross-sectional survey from April 2012 to May 2018 in the northeastern, northwestern, and southern regions of China, with a total enrollment of 179,846 children aged 6-18 years.

Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery.

With the unique photo-physical properties and strong bio-compatibility. Quantum dots (QDs) have sparked interest in biomedical fields such as imaging, biosensing and therapeutics. However, the low stability and insufficient tumor specificity have largely constrained their potential biomedical applications.

Integration of network toxicology and transcriptomics reveals the novel neurotoxic mechanisms of 2, 2', 4, 4'-tetrabromodiphenyl ether.

The brominated flame retardant 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47) is known as a developmental neurotoxicant, yet the underlying mechanisms remain unclear. This study aims to explore its neurotoxic mechanisms by integrating network toxicology with transcriptomics based on human neural precursor cells (hNPCs) and neuron-like PC12 cells. Network toxicology revealed that PBDE-47 crosses the blood-brain barrier more effectively than heavier PBDE congeners, and is associated with disruptions in 159 biological pathways, including cytosolic DNA-sensing pathway, ferroptosis, cellular senescence, and chemokine signaling pathway.

Silent threats of lead-based paints in toys and households to children's health and development.

Lead (Pb), a highly toxic heavy metal, poses a significant global health risk, particularly to children. Widely used in paint manufacturing for its remarkable corrosion-resistance properties Pb exposure has been linked to severe health issues, including reduced neurotransmitter levels, organ damage, potentially leading to death in extreme cases. Children Are particularly vulnerable, with Pb toxicity primarily affecting the brain, reproductive, kidneys, and cardiovascular systems.

Morusin regulates the migration of M2 macrophages and GBM cells through the CCL4-CCR5 axis.

Background: Glioblastoma (GBM) is the most aggressive tumor in the central nervous system. Tumor-associated macrophage (TAMs) represent a major immune cell population in tumor microenvironment (TME) and exert immunosuppressive effects that impede GBM treatment. Morusin is a flavonoid extracted from mulberry trees and has anti-tumor properties against various cancers, including glioma.

Zeolite-like algal biochar nanoparticles for enhanced antibiotics removal: Sorption mechanisms and theoretical calculations.

In the study, Sargassum horneri (S. horneri) was used to create a novel zeolite-like algal biochar (KSBC). KSBC with doping of N, O, S, Al, and Si, displayed zeolite-like properties, including well-developed porosity, a high specific surface area (1137.

Rebalancing immune homeostasis in combating disease: The impact of medicine food homology plants and gut microbiome.

Background: Gut microbiota plays an important role in multiple human physiological processes and an imbalance in it, including the species, abundance, and metabolites can lead to diseases. These enteric microorganisms modulate immune homeostasis by presenting a myriad of antigenic determinants and microbial metabolites. Medicinal and food homologous (MFH) plants, edible herbal materials for both medicine and food, are important parts of Traditional Chinese Medicine (TCM).

Concentrations, composition profiles, and in vitro-in silico-based mixture risk assessment of bisphenol A and its analogs in plant-based foods.

The substitution of bisphenol A (BPA) with structurally similar analogs has raised concerns due to their comparable estrogenic activities. Considering the high consumption of plant-based foods, assessing the risks posed by bisphenols (BPs) in such dietary sources is essential. However, limited exposure and animal toxicological data on BP analogs hinder comprehensive risk assessments.

The Cardioprotective Effect of Ginseng Derived Exosomes via Inhibition of Oxidative Stress and Apoptosis.

Ginsenosides possess potential protective effects against cisplatin (CDDP)-induced toxicity, but the limited bioavailability of ginsenosides hampered their therapeutic application. Ginseng exosomes (G-Exo), which are active ingredients in ginseng, exhibit excellent biocompatibility and low immunogenicity. Here, G-Exo were isolated from ginseng roots through a combination of ultracentrifugation and sucrose gradient centrifugation techniques.

Plant Volatile Methyl Salicylate Primes Wheat Defense Against the Grain Aphid by Altering the Synthesis of Defense Metabolites.

Wheat (Triticum aestivum L.) is one of the most important staple crops all over the world. Its productivity is adversely affected by aphid infestation.

Cascade Selenization Regulated the Electronic Structure and Interface Effect of Transition Metal Sulfides for Enhanced Sodium Storage.

The utilization of cobalt-based sulfides is constrained by their inherently low conductivity and slow sodium ion diffusion kinetics. Modifying the electronic configuration and constructing heterostructures are promising strategies to enhance intrinsic conductivity and expedite the sodium ion diffusion process. In this study, heterogeneous nanoparticles of Se-substituted CoS/CoSe, embedded within heteroatom-modified carbon nanosheet, were synthesized using metal molten salt-assisted dimensionality reduction alongside concurrent sulfurization and selenization techniques.

Correction: Long non-coding RNA SNHG17 may function as a competitive endogenous RNA in diffuse large B-cell lymphoma progression by sponging miR-34a-5p.

[This corrects the article DOI: 10.1371/journal.pone.

The Evaluation of Right Ventricular Synchrony by Two-Dimensional Speckle Tracking Echocardiography in Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.

Objectives: Numerous studies have demonstrated impaired right ventricular (RV) synchronicity in pulmonary arterial hypertension (PAH). However, few studies have focused on connective tissue disease (CTD)-associated PAH. This study evaluates RV dyssynchrony and its prognostic value in CTD-associated PAH.

High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.

Aim: Imbalanced M1/M2 macrophage phenotype activation is a key point in diabetic kidney disease (DKD). Macrophages mainly exhibit the M1 phenotype, which contributes to inflammation and fibrosis in DKD. Studies have indicated that autophagy plays an important role in M1/M2 activation.

A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.

The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have been informative in defining macrophage subtypes. Studies show pro and anti-inflammatory macrophages exhibit distinct migratory behaviors, in vitro, in 3D and in vivo but this link has not been rigorously studied.

Data mining of adverse drug event signals with Nirmatrelvir/Ritonavir from FAERS.

Nirmatrelvir/Ritonavir, acting as an effective agent against COVID-19, has achieved considerable results in clinical studies in terms of drug efficacy. However, there is little research about its medication safety. Based on the FDA adverse event reporting system (FAERS) database, this study aims to mine the adverse reaction signals of the latest major recommended drug Nirmatrelvir/Ritonavir for the antiviral treatment of COVID-19, so as to provide a basis for safe and rational drug use.

Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.

Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding of GPX4 protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein.