Publications by authors named "Jing-liao Zhang"
[Establishment of BCL-2 Inhibitors-Resistant B-cell Acute Lymphoblastic Leukemia Cell Lines and Study on Their Resistance Mechanisms].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2024
Objective: RS4;11 cell line was used to establish BCL-2 inhibitor-resistant cell lines of B-cell acute lymphoblastic leukemia (B-ALL) and explore the possible mechanisms of drug resistance.
Methods: RS4;11 cell line was continuously induced and cultured by low and ascending concentrations of BCL-2 inhibitors navitoclax and venetoclax to construct navitoclax-resistant cell line RS4;11/Nav and venetoclax-resistant cell line RS4;11/Ven. The cell viability was detected by MTT assay, and the cell apoptosis was detected by flow cytometry.
[Clinical Characteristics and Prognosis Analysis of Pediatric Severe Aplastic Anemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2021
Article Synopsis
- - The study analyzed clinical characteristics and prognosis factors in 205 children with severe aplastic anemia (SAA) treated from 2008 to 2018, focusing on their response to immunosuppressive therapy (IST).
- - Results showed that by 12 months post-treatment, over 73% of patients had a positive response, and the 5-year overall survival rate was impressive at 93.1%.
- - While the mode of delivery (spontaneous vs. cesarean) seemed to have an impact on short-term survival rates, it was not significant in the long term, and a recent history of home or school decoration was linked to better short-term responses to treatment.
Article Synopsis
- - Dasatinib, a drug used to treat CBF-AML, was tested in a study with 20 children to assess its pharmacokinetics and safety when combined with standard chemotherapy.
- - Blood samples were taken to analyze dasatinib concentrations, revealing that the drug’s effectiveness (measured by AUC) in children was comparable to that in adults, with some adverse effects mostly being mild (grade 1/2).
- - The study found high rates of complete remission (95%) and molecular response (75.5%) in pediatric patients, indicating that dasatinib is well-tolerated and effective for treating CBF-AML in children.
[Advances in the treatment of juvenile myelomonocytic leukemia].
Zhongguo Dang Dai Er Ke Za Zhi
November 2018
Article Synopsis
- Juvenile myelomonocytic leukemia (JMML) is a rare, aggressive type of cancer in children that combines elements of myelodysplastic syndrome and myeloproliferative neoplasm.
- Traditional chemotherapy is largely ineffective for treating JMML, making hematopoietic stem cell transplantation the only viable cure currently available.
- Recent advancements in targeted therapies, particularly focusing on mutations in the Ras signaling pathway and demethylation treatment for certain genetic abnormalities, have shown promise in improving treatment outcomes.
[Value of multiparameter flow cytometry in the diagnosis and prognostic evaluation of childhood myelodysplastic syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
October 2018
Article Synopsis
- - The study aimed to evaluate the effectiveness of multiparameter flow cytometry (MFC) and the flow cytometric scoring system (FCSS) in diagnosing and predicting outcomes for children with myelodysplastic syndrome (MDS).
- - A retrospective analysis of 42 MDS-diagnosed children revealed significant correlations between FCSS scores and various MDS types, as well as established prognostic scoring systems, indicating that FCSS can effectively classify risk levels.
- - Results showed that the low-risk FCSS group had the best survival rates, while the medium- and high-risk groups performed similarly, highlighting the importance of FCSS in identifying prognosis and guiding treatment decisions.
Objective: To evaluate the clinical characteristics and risk factors of clonal evolution after immunosuppressive therapy (IST) in children with severe/very severe aplastic anemia (SAA/VSAA).
Methods: The clinical data of 231 children with newly-diagnosed SAA/VSAA who received IST were retrospectively studied. The incidence and risk factors of clonal evolution after IST were analyzed.
[Prognostic Value of Prednisone Response in CCLG-ALL 2008].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2015
Article Synopsis
- The study aimed to assess how well children with acute lymphoblastic leukemia (ALL) respond to prednisone treatment as a predictor of their prognosis.
- A total of 598 newly diagnosed ALL patients were treated with prednisone and were divided into two groups based on their lymphoblast counts on day 8: good responders (PGR) and poor responders (PPR).
- The results showed that PPR patients had poorer outcomes, including lower event-free survival rates and higher relapse rates, suggesting that PPR status indicates a higher risk and worse overall prognosis.*
[Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia].
Zhongguo Dang Dai Er Ke Za Zhi
January 2015
The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application of BM-MSCs in the treatment of acquired AA. An increasingly number of laboratory statistics has demonstrated that the defectiveness of BM-MSCs is more likely to play an important role in the pathogenesis of AA, namely, the apparently different biological characteristics and gene expression profiles, the decreased ability of supporting hematopoiesis as well as self-renewal and differentiation, and the exhaustion of regulating immune response of hematopoietic environment.
View Article and Find Full Text PDFObjective: To construct a three-dimensional model to demonstrate the relation between the anterior branches of lumbosacral 4,5, lumbosacral trunk, and the pelvis.
Methods: An formaldehyde-fixed adult cadaver was dissected to expose the anterior branches of the lumbar nerves 4 and 5, lumbosacral trunk and the sacroiliac. The mixture of titanium powder and adhesive was smeared on the surface of the major branches of L4 and L5 nerves, lumbosacral trunk, femoral nerves and obturator nerves.