[Distribution of 5-FU in rat plasma and liver tissue after local 5-FU infusion].

Objective: To study the distribution of 5-FU in rat plasma and liver tissue following systemic or local 5-FU infusion.

Methods: 5-FU was administered at the dose of 20 mg/kg systemically via bolus injection through the jugular vein or locally via infusion through the hepatic artery and portal vein of the rats. High-performance liquid chromatography was used to measure 5-FU concentration in the plasma and liver tissue, and the pharmacokinetic parameters, penetration rate and therapeutic dominance of 5-FU were calculated.