Publications by authors named "Jing-le Li"
Article Synopsis
- * A total of 34 subjects were analyzed, divided into elderly and young groups, and received a specific dosing regimen of dexmedetomidine with blood samples collected for analysis over 10 hours.
- * Results indicated that dexmedetomidine's pharmacokinetics could be described by a three-compartment model, with age, body weight, and alanine aminotransferase levels identified as significant factors affecting drug clearance and volume.
[Effect of IL-10 on LOX-1 expression of peripheral blood monocytes in patients with acute coronary syndrome].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
February 2008
Objective: To determine the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) of peripheral blood monocytes in patients with acute coronary syndromes (ACS),and to further explore the effect of anti-inflammatory factor interleukin-10 (IL-10) on the expression of LOX-1.
Methods: Twenty-eight healthy controls and 28 ACS patients were enrolled in the study. The levels of IL-10 and tumor necrosis factor (TNF-alpha) were determined by enzyme-linked immunosorbnent assay(ELISA).
[Proatherogenic effects of immune complexes of human oxLDL in vitro].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
April 2005
Objective: To observe the effects of immune complexes (IC) prepared from human oxidized density lipoprotein (oxLDL) antibodies and human oxLDL on the foam cell forming and the macrophage activation, and to further uncover the possible mechanisms of immune complexes contributing to the atherosclerosis occurrence.
Methods: The immune complexes of human oxLDL and purified human oxLDL antibodies were added to culture U937 cells by protocols: polyethylene glycol-precipitated insoluble IC (PEG-IC) and IC immobilized by absorption to red blood cells (RBC-IC). With oxLDL as controls and heat-aggregated gamma globulin as an inhibitor of Fc gamma receptor, we measured the cholesterol ester, total cholesterol of the cellular extracts, and quantified the secreted MMP-1 of supernatants from U937 cells.