Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study.

Objective: This study was to investigate the efficacy and safety of gefitinib plus anlotinib for patients with EGFR positive advanced non-small cell lung cancer (NSCLC) in a first-line setting.

Methods: A total of 36 patients with previously-untreated EGFR positive advanced NSCLC were included in this study retrospectively. All patients were administered with gefitinib plus anlotinib combination therapy.

MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway.

In the present study, the therapeutic effects and the underlying molecular mechanisms of microRNA (miR)‑145 were investigated in non‑small cell lung cancer (NSCLC) cells. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to examine miR‑145 expression. An MTT assay and flow cytometry were used to investigate cell proliferation and apoptosis, respectively.

Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR.

The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Overall survival of higher expression in cisplatin-induced NSCLC patients was higher than that of lower expression in cisplatin‑induced NSCLC patients.

[Effect of temperature and applied voltage on the recombination efficiency in double layer organic light emitting diodes].

In this paper, the theoretical model of recombination was presented and the effect of temperature and applied voltage on the recombination efficiency was investigated in double layer organic light-emitting diodes: ITO/PPV/PBD/Ca. At lower applied voltage, two peaks have been observed in the curve of recombination efficiency vs. temperature.

[Defect modes in one-dimensional comblike photonic crystals].

The photonic band structures and the effect of defect states on photonic band gap in a comblike waveguide geometry which were made of dangling side branches grafted periodically along an infinite monomode waveguide were investigated in this paper. It was discovered that the photonic forbidden bands originates from both the periodicity of the system and the resonance states of the grafted branches. By removing or inserting some defect branches in the star waveguide of finite number of grafted branches, the localized states appear in the transmission spectrum as very narrow peaks.

[Mechanism and fluorescence spectra of 5,6,11,12-tetraphenyl-tetracene doped 8-hydroxyquinoline system].

The PL and EL spectra of 5,6,11,12-tetraphenyl-tetracene doped 8-hydroxyquinoline are measured. It is found that Alq is host emitter when dopant concentration is low, and a discrete level is introduced by doping Rubrene (guest emitter) in Alq energy gap. As increasing Rubrene concentration, Rubrene is host emitter but Alq becomes guest emitter.

[Influences of transport layers barriers on recombination efficiency in bilayer organic devices].

Based on the physical processes of carriers transport and recombination, a multi-barriers model for carriers transport and recombination in bilayer organic devices is present. The influences of applied bias and thin films (transport layers) barriers on carriers recombination and its efficiency are calculated and discussed. In bilayer organic devices the charge density inside the sample is controlled by interfacial charge accuulation.