SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence.

Heart senescence is critical for cardiac function. This study aimed to characterize the role and mechanism of action of miR-30a-5p in cardiac senescence. miR-30a-5p was downregulated in aged mouse hearts and neonatal rat cardiomyocytes (NRCMs).

Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.

Context: Concanavalin A (Con A) exhibited multiple roles in cancer cells. However, the role of Con A in endothelial cells was not reported.

Objective: Our present study investigated the potential angiogenic role of Con A in endothelial cells and ischaemic hind-limb mice.

Ubiquitinated ligation protein NEDD4L participates in MiR-30a-5p attenuated atherosclerosis by regulating macrophage polarization and lipid metabolism.

MiR-30a-5p plays an important role in various cardiovascular diseases, but its effect in atherosclerosis has not been reported. Apolipoprotein E-deficient (Apo E) mice were used to investigate the role of miR-30a-5p in atherosclerosis, and the underlying mechanism was investigated and . The fluorescence hybridization test revealed that miR-30a-5p was expressed in Apo E mice lesions.

Pretreatment of cardiac progenitor cells with bradykinin attenuates HO-induced cell apoptosis and improves cardiac function in rats by regulating autophagy.

Background: Previous studies have demonstrated that human cardiac c-Kit progenitor cells (hCPCs) can effectively improve ischemic heart disease. However, the major challenge in applying hCPCs to clinical therapy is the low survival rate of graft hCPCs in the host heart, which limited the benefit of transplanted hCPCs. Bradykinin (BK) is a principal active agent of the tissue kinin-kallikrein system.

Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure.

Aim: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis.

Methods: Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis.

Tape-Based Photodetector: Transfer Process and Persistent Photoconductivity.

We report a facile transfer method to fabricate flexible photodetectors directly on tape, wherein the films formed by different processes were integrated together. The tape-based photodetectors with CdS nanowire (NW) active layers exhibited good performances as those fabricated by conventional processes. The obvious persistent photocurrent in our device was eliminated by introducing a conductive polymer poly(3,4-ethylenedioxythiophene)polystyrene sulfonate (PEDOT:PSS) onto the CdS NW layer.