Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling.

The present study aims to provide evidence on the potential protective role of Bunge (Danshen) and its bioactive compound Tanshinone IIA (TanIIA) in AKI and to reveal the specific regulatory function of PXR/NF-κB signaling in AKI-induced renal inflammation. A network pharmacological analysis was used to study target genes and regulatory networks in the treatment of on AKI. Further experiments with AKI mouse model and studies were applied to investigate the renal protective effect of TanIIA in AKI.

Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis.

Renal fibrosis is one of the most characterized pathological features in chronic kidney disease (CKD). Progressive fibrosis eventually leads to renal failure, leaving dialysis or allograft transplantation the only clinical option for CKD patients. Transforming growth factor-β (TGF-β) is the key mediator in renal fibrosis and is an essential regulator for renal inflammation.