Publications by authors named "Jing-Ying Fan"
Article Synopsis
- The study aimed to explore how sanguinarine (SAN) affects nasopharyngeal carcinoma (NPC) using network pharmacology and molecular techniques.
- Researchers identified 95 targets for SAN against NPC, narrowing it down to 8 core targets through analysis, including EGFR and TP53.
- Results showed that SAN effectively inhibited NPC cell growth and triggered apoptosis by altering the expression of specific proteins, linking its effects to significant signaling pathways like PI3K/AKT and MAPK.
Introduction: Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has a well-known anti-tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role in the progression of GC. However, the relationship between miR-34a and the susceptibility of GC cells to PD is still unclear.
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- - The study investigates the impact of Yiqi Jiedu formula (YQ) on the growth of CNE2 cells in nasopharyngeal carcinoma, aiming to provide a foundation for its clinical use.
- - YQ treatment significantly reduces CNE2 cell proliferation in a dose- and time-dependent manner, with a calculated IC₅₀ value of 0.5 g·L⁻¹ after 48 hours.
- - The mechanism involves changes in the cell cycle and down-regulation of key proteins in the MAPK/ERK signaling pathway, indicating how YQ affects cancer cell growth and cycle progression.