Publications by authors named "Jing-Yin Jia"
Article Synopsis
- The study aims to develop a population pharmacokinetic (PPK) model of huperzine A, an Alzheimer's medication, specifically in elderly Chinese individuals, as existing pharmacokinetic data for this group is lacking.
- Researchers analyzed 341 serum concentration records from clinical trials, focusing on factors like age, gender, and body weight using advanced modeling techniques.
- The final PPK model indicates that age significantly affects the clearance of huperzine A, providing a reliable tool to optimize its administration in elderly patients with Alzheimer's disease.
Liraglutide Improves the Survival of INS-1 Cells by Promoting Macroautophagy.
Int J Endocrinol Metab
December 2013
Background: Type 2 diabetes mellitus (T2D) is a metabolic disease characterized by dysfunction of pancreatic beta cell and insulin resistance. Liraglutide, which has many special anti-diabetes biological effects, is found to inhibit beta cell death and ameliorate endoplasmic reticulum stress (ERs) induced by free fatty acid (FFA). Macroautophagy (hereafter referred to as autophagy) altered by FFA is also associated with the dysfunction or death of pancreatic beta cells.
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