Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring.

Objective: This study aimed to assess the associations between maternal drug use, cytochrome P450 ( ) genetic polymorphisms, and their interactions with the risk of congenital heart defects (CHDs) in offspring.

Methods: A case-control study involving 569 mothers of CHD cases and 652 controls was conducted from November 2017 to January 2020.

Results: After adjusting for potential confounding factors, the results show that mothers who used ovulatory drugs (adjusted odds ratio [a ] = 2.

[Association between maternal reduced folate carrier gene polymorphisms and congenital heart disease in offspring: a case-control study].

Objective: To study the association between maternal reduced folate carrier () gene polymorphisms and congenital heart disease (CHD) in offspring.

Methods: A hospital-based case-control study was conducted. The mothers of 683 infants with CHD who attended the Department of Cardiothoracic Surgery, Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group.

[Association of maternal diabetes mellitus and UCP2 gene polymorphisms with congenital heart disease in offspring: a case-control study].

Objective: To study the association of maternal diabetes mellitus (DM), uncoupling protein 2 (UCP2) gene polymorphisms, and their interaction with the risk of congenital heart disease (CHD) in offspring.

Methods: A hospital-based case-control study was conducted. A total of 464 mothers of children with CHD alone who were diagnosed in Hunan Children's Hospital from March 2018 to August 2019 were enrolled as the case group.