Publications by authors named "Jing-Yang Ding"
Article Synopsis
- - Six different oxidosqualene cyclases (OSC1-OSC6) were studied for their role in creating various triterpene structures, including both tetracyclic and pentacyclic forms from two starting materials: 2,3-oxidosqualene and 2,3:22,23-dioxidosqualene.
- - OSC1 was particularly effective at producing rare (20)-epimers of oxacyclic triterpenes, and a mutant version of OSC1 (F731G) significantly enhanced the production of these (20)-epimers compared to the normal OSC1.
- - The study utilized homology modeling and molecular docking techniques to explain how the (20)-configuration develops during the epoxide
