Publications by authors named "Jing-Yan Ge"
Role of activin A in carbon tetrachloride-induced acute liver injury.
World J Gastroenterol
June 2013
Aim: To investigate the expression and role of activin A in a mouse model of acute chemical liver injury.
Methods: Acute liver injury in C57BL/6 male mice was induced by intraperitoneal injection with carbon tetrachloride (CCl4) (0.5 mL/kg, body weight) dissolved in olive oil (1:19 v/v).
Activin is a neurotrophic and neuroprotective factor in the central nervous system. Activin receptor-interacting protein 1 and 2 (ARIP1 and ARIP2) are identified as activin signal proteins in mouse brain. However, whether ARIP1 and ARIP2 are co-expressed in nerve cells and the differences of their biological activities are not well characterized.
View Article and Find Full Text PDFActivin A, a member of the transforming growth factor β (TGFβ) superfamily, plays an essential role in neuron survival as a neurotrophic and neuroprotective factor in the central nervous system. However, the effects and mechanisms of action of activin A on the neurite outgrowth of dorsal root ganglia (DRG) remain unclear. In the present study, we found that activin A is expressed in DRG collected from chicken embryos on embryonic day 8 (E8).
View Article and Find Full Text PDFArticle Synopsis
- ARIP2 is a protein that regulates activin signaling, which is important for FSH secretion in reproductive tissues.
- Recent studies show that ARIP2 is widely expressed in various mouse tissues, including the heart, testis, and lungs.
- Overexpression of ARIP2 leads to a decrease in activin-induced signaling and FSH secretion in pituitary cells, indicating it may act as a negative regulator in this process.