Effects of Prolonged Cold Stress on Vascular Function in Guinea Pigs With Atherosclerosis.

Research Objective: This study explored the effects of long-term cold stress (CS) on aortic vascular function in guinea pigs.

Research Methods: Hartley guinea pigs (n = 32) were divided into the following groups: atherosclerosis (AS), CS, and menthol-stimulated (M), and control (C). On days 1, 15, 30, 45, and 60, guinea pigs in the AS, CS, and M groups were intraperitoneally injected with bovine serum albumin.