Publications by authors named "Jing-Wei Cao"
Investigation on Potential Biomarkers and Immune-Related Mechanisms of Ischemic Stroke.
J Integr Neurosci
September 2022
Background: This study aimed to reveal the detailed immune-related mechanisms underlying ischemic stroke (IS) and identify new immune-associated biomarkers for clinical management.
Methods: Differentially expressed genes (DEGs) between IS samples and normal controls were identified using the GSE16561 dataset. The feature genes of the immune cells were investigated using the GSE72642 dataset.
Hypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro.
View Article and Find Full Text PDFIschemic stroke is a major global health issue. Ischemia and subsequent reperfusion results in stroke-related brain injury. Previous studies have demonstrated that nuclear-enriched abundant transcript 1 (NEATa and early growth response 1 (EGR1) are involved in ischemia reperfusion (IR) injury).
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease (AD) is a neurodegenerative disorder where the role of lncRNA RMRP has mainly been studied in cancer, but its function in AD is unclear.
- The study used human serum samples, AD transgenic mice, and SH-SY5Y cells to assess the expressions of RMRP, miR-3142, and TRIB3, and examined their roles in apoptosis and autophagy.
- Results showed that knocking down RMRP reduced neuron death and autophagy, and RMRP appears to promote TRIB3 levels by sponging miR-3142, indicating that targeting RMRP could be a potential treatment for AD.
Objective: Impaired immunonutritional status has disadvantageous effects on outcomes for cancer patients. Preoperative albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI) have been used as prognostic factors in various cancers. We aimed to evaluate the clinical significance of the AGR and PNI in glioblastoma.
View Article and Find Full Text PDFObjective: To discuss the significance of the radiculomuscular artery in typical variations of the distal vertebral artery (VA) from the viewpoint of microsurgical anatomy.
Methods: Some variations involving the radiculomuscular artery revealed by digital subtraction angiography (DSA) were recruited and studied together with our findings from cadaver dissections.
Results: A total of 29 variants were found in 26 patients, including 10 C‑2 vertebral origins of the posteroinferior cerebellar artery (PICA), 13 duplicated (12 patients) and 6 aberrant V3s.