HRD1 attenuates the high uptake of [F]FDG in hepatocellular carcinoma PET imaging.

Introduction: Due to individual deviations in tumor tissue uptake, the role of [F]fluorodeoxyglucose ([F]FDG) positron emission tomography (PET) in hepatocellular carcinoma (HCC) diagnosis is limited. β-Hydroxy β-methylglutaryl-CoA reductase degradation 1 (HRD1) plays a key role in clearing misfolded proteins. This study is aimed to investigate the role and mechanism of HRD1 in [F]FDG uptake for the diagnosis of HCC.