[Characteristics and Driving Mechanisms of Shallow Groundwater Chemistry in Xining City].

Groundwater is one of the major sources of water supply, especially in the western arid regions. However, with the deepening of the western development strategy, industrialization and urbanization have increased groundwater resource demands in Xining City. Overexploitation and utilization have led to a series of changes in the groundwater environment.

MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition.

Objective: Little is known about the role of microRNA-29a-3p (miR-29a-3p) in inflammation-related pyroptosis, especially in drug-induced acute liver failure (DIALF). This study aimed to identify the relationship between miR-29a-3p and inflammation-related pyroptosis in DIALF and confirm its underlying mechanisms.

Methods: Thioacetamide (TAA)- and acetaminophen (APAP)-induced ALF mouse models were established, and human samples were collected.

[Analysis on Contamination Characteristics, Pollution Source Identification and Ecological Risk Assessment of Polycyclic Aromatic Hydrocarbons of Groundwater in a Large Coking Plant Site of Province].

Polycyclic aromatic hydrocarbons (PAHs), as a highly toxic persistent organic pollutant, are commonly found in soil and water environments. In recent years, the pollution of PAHs in groundwater has attracted wide attention from scientists. To study the pollution characteristics and sources of polycyclic aromatic hydrocarbon in groundwater of the coking site, 16 PAHs priorly controlled by the US EPA were analyzed and discussed.

[Hydrochemical and Isotopic Evidence for Groundwater Conversion of Surface Water in Alpine Arid Areas: A Case Study of the Datong River Basin].

Global warming and regional extreme climates will lead to unbalanced rainfall, melting glaciers, and permafrost degradation in alpine and arid mountain plains, thereby changing the regional hydrological cycle. The relationship between surface water and groundwater conversion is one of the important scientific issues of hydrological cycle climate response in alpine arid areas. Taking the Datong River Basin at the southern foot of the Qilian Mountains as the study area, based on 119 sets of basic hydrochemical parameters and deuterium-oxygen isotope data, using multivariate statistical analysis and isotopic techniques, the hydrochemical characteristics of surface water and groundwater in the basin and their mutual transformation process were studied.

[Characteristics and Causes of High-manganese Groundwater in Pearl River Delta During Urbanization].

The high concentration of iron and manganese in groundwater is harmful to human health, and the sources of manganese in rapidly urbanization areas are complex. Based on more than 2500 sets of hydrochemical data in different historical periods, the spatial distribution characteristics, sources, and genesis of groundwater manganese in different aquifers and areas with different urbanization levels in the Pearl River Delta were studied by using mathematical statistics and principal component analysis. The results showed that the concentration of manganese in groundwater in the pore aquifer was obviously higher than that in the fissure and karst aquifer.

Rising Shallow Groundwater Level May Facilitate Seed Persistence in the Supratidal Wetlands of the Yellow River Delta.

The saline groundwater level of many supratidal wetlands is rising, which is expected to continue into the future because of sea level rise by the changing climate. Plant persistence strategies are increasingly important in the face of changing climate. However, the response of seed persistence to increasing groundwater level and salinity conditions is poorly understood despite its importance for the continuous regeneration of plant populations.

[Geochemical Characteristics and Driving Factors of High-Iodine Groundwater in Rapidly Urbanized Delta Areas: A Case Study of the Pearl River Delta].

The source of iodine in the groundwater of coastal urbanization areas is complex, and high-iodine groundwater is a potential threat to the safety of drinking water. Based on this, this study took the Pearl River Delta, which is developing rapidly in urbanization, as the research area. Additionally, the occurrence characteristics and driving factors of iodide in shallow groundwater of different aquifers and different urbanization levels in the Pearl River Delta were studied using mathematical statistics, principal component analysis, and other methods.

[Geochemical Characteristics and Driving Factors of NO-Type Groundwater in the Rapidly Urbanizing Pearl River Delta].

In response to rapid economic development, nitrate pollution of groundwater is becoming a serious issue in many parts of China. Urbanization and industrialization are the main drivers of NO-type groundwater expansion. Focusing on the Pearl River Delta, the occurrence and driving factors of shallow nitrate groundwater are discussed.

Coordinative mediation of the response to alarm pheromones by three odorant binding proteins in the green peach aphid Myzus persicae.

Odorant binding proteins (OBPs) play an essential role for insect chemosensation in insect peripheral nervous systems of antennae. Each antennal sensilla contains more than one OBP at high concentrations but the interactions and cooperation between co-localized OBPs are rarely reported. In present study, we cloned, expressed and purified eight OBPs of the green peach aphid Myzus persicae.

[Effects of biochar and EM application on growth and photosynthetic characteristics of in saline-alkali soil of the Yellow River Delta, China].

We examined the effects of biochar and effective mircoorganisms (EM) application on growth and photosynthetic characteristics of in the Yellow River Delta, by a pot experiment with different EM treatments (without EM addition, EM-; with EM addition, EM+) and a gradient of biochar treatments (0, B; 0.5%, B; 1.5%, B; 3%, B; biochar weight/soil weight).

Specific Inhibitor of Matrix Metalloproteinase Decreases Tumor Invasiveness After Radiofrequency Ablation in Liver Tumor Animal Model.

Objective: To determine whether the specific inhibitor of matrix metalloproteinase (MMP)-batimastat (BB-94)-could decrease the progression of liver tumor after radiofrequency ablation (RFA) and achieve better therapeutic efficacy in an animal model.

Methods: experiments, the proliferation of H22 liver tumor cells was detected by CCK 8 assay and cell migration was detected by Transwell method. experiments, H22 murine liver tumors were used.

Pharmacogenetic impact of UGT1A1 polymorphisms on pulmonary neuroendocrine tumours treated with metronomic irinotecan-based chemotherapy in Chinese populations.

Objectives: To evaluate the effects of UGT1A1*6 and UGT1A1*28 polymorphisms on the safety and efficacy of metronomic irinotecan-based chemotherapy (IBC) in Chinese patients with pulmonary neuroendocrine tumours (PNTs).

Methods: Sixty-eight PNT patients who received metronomic IBC were observed. The quantitative fluorescent polymerase chain reaction was used to detect UGT1A1*6 and UGT1A1*28 polymorphisms.

[Chemical Evolution of Groundwater in the Tacheng Basin of Xinjiang in the Process of Urbanization].

With the development of the local economy, the volume of groundwater production has increased continuously in the past decades in the Tacheng Basin of the Xinjiang Uygur Automous Region. Previous studies have not provided a clear pattern of the chemical composition evolution of groundwater and its driving force in this basin, which makes the future development and utilization of groundwater riskier. This study carried out systematic sampling and analysis of groundwater chemistry in this basin, and the chemical evolution of groundwater in the basin was analyzed by comparison with historical hydrochemical data.

[Effects of multiple times of topdressing nitrogen application under equal level on utilization and distribution characteristics of N and C in winter jujube].

We explored the effects of multiple times of topdressing nitrogen application under equal level on the characteristics of absorption, utilization, accumulation, and distribution of N and C in four-year-old potted winter jujube during fruit developmental periods using the stable isotope tra-cer technology. The results showed that with the increases of nitrogen application times, the N derived from fertilizer (Ndff) in each organ significantly increased at the fruit maturity. The distribution rates of N in reproductive organ (fruit) and vegetative organs (leaf, deciduous spur, new branch, and fine root) were highest under four-time application, and lowest under one-time application.

Expressional and functional comparisons of two general odorant binding proteins in Agrotis ipsilon.

Insect general odorant binding proteins (GOBPs) have been long thought to bind and transport host plant volatiles to the olfactory receptors on the dendrite membrane of the olfactory neurons. Recent studies indicate that they can also bind female sex pheromones. In present study, two GOBP genes, AipsGOBP1 and AipsGOBP2 were cloned from the adult antennae of Agrotis ipsilon.

Characterization of antennal chemosensilla and associated odorant binding as well as chemosensory proteins in the parasitoid wasp Microplitis mediator (Hymenoptera: Braconidae).

Odorant binding proteins (OBPs) and chemosensory proteins (CSPs) expressed in antennal chemosensilla are believed to be important in insect chemoreception. In the current study, we fully described the morphological characteristics of the antennal sensilla in parasitoid wasp Microplitis mediator and analyzed the expression patterns of OBPs and CSPs within the antennae. In M.

[Water use strategy of Tamarix chinensis during a drought year in the coastal wetlands of the Yellow River Delta, China].

Tamarix chinensis, the dominant species of plant communities in the coastal wetlands of the Yellow River Delta, was selected to study the water use strategy of coastal plants at different habitats during a drought year. The ΔO values for xylem water of T. chinensis were analyzed.

Key site residues of pheromone-binding protein 1 involved in interacting with sex pheromone components of Helicoverpa armigera.

Pheromone binding proteins (PBPs) are widely distributed in insect antennae, and play important roles in the perception of sex pheromones. However, the detail mechanism of interaction between PBPs and odorants remains in a black box. Here, a predicted 3D structure of PBP1 of the serious agricultural pest, Helicoverpa armigera (HarmPBP1) was constructed, and the key residues that contribute to binding with the major sex pheromone components of this pest, (Z)-11- hexadecenal (Z11-16:Ald) and (Z)-9- hexadecenal (Z9-16:Ald), were predicted by molecular docking.

Early fluid loading for septic patients: Any safety limit needed?

Early adequate fluid loading was the corner stone of hemodynamic optimization for sepsis and septic shock. Meanwhile, recent recommended protocol for fluid resuscitation was increasingly debated on hemodynamic stability vs risk of overloading. In recent publications, it was found that a priority was often given to hemodynamic stability rather than organ function alternation in the early fluid resuscitation of sepsis.

Identification of odorant binding proteins and chemosensory proteins in Microplitis mediator as well as functional characterization of chemosensory protein 3.

Odorant binding proteins (OBPs) and chemosensory proteins (CSPs) play important roles in transporting semiochemicals through the sensillar lymph to olfactory receptors in insect antennae. In the present study, twenty OBPs and three CSPs were identified from the antennal transcriptome of Microplitis mediator. Ten OBPs (MmedOBP11-20) and two CSPs (MmedCSP2-3) were newly identified.

RNAi-Induced Electrophysiological and Behavioral Changes Reveal two Pheromone Binding Proteins of Helicoverpa armigera Involved in the Perception of the Main Sex Pheromone Component Z11-16:Ald.

Pheromone binding proteins (PBPs) are thought to play key roles in insect sex pheromone recognition; however, there is little in vivo evidence to support this viewpoint in comparison to abundant biochemical data in vitro. In the present study, two noctuid PBP genes HarmPBP1 and HarmPBP2 of the serious agricultural pest, Helicoverpa armigera were selected to be knocked down by RNA interference, and then the changes in electrophysiological and behavioral responses of male mutants to their major sex pheromone component (Z)-11-hexadecenal (Z11-16:Ald) were recorded. There were no significant electrophysiological or behavioral changes of tested male moths in response to Z11-16:Ald when either single PBP gene was knocked down.

[Response of active nitrogen to salinity in a soil from the Yellow River Delta].

Soil salinity can inhibit the processes of nitrogen cycle, and the active nitrogen is the important indicator to reflect the turnover of nitrogen. A laboratory experiment was conducted to study the effect of soil salinity on the active nitrogen in a soil of the Yellow River Delta incubated aerobically under 25 degrees C for 45 days. Four levels of salinity (S1: 0.

[Quality level assessment of lowly efficient Tamarix chinensis secondary shrubs in Laizhou Bay of Yellow River Delta].

Taking the Tamarix chinensis secondary shrubs in Laizhou Bay of Yellow River Delta as test objects, and by using synthetic factor method, this paper studied the main factors causing the lowly efficiency of T. chinensis secondary shrubs as well as the main parameters for the classification of lowly efficient T. chinensis secondary shrubs.

Factors associated with low adherence to head-of-bed elevation during mechanical ventilation in Chinese intensive care units.

Background: Elevating the head of bed (HOB) 30° - 45° has been widely supported as a means of ventilator associated pneumonia (VAP) prevention. However, it was poorly adhered in clinical practice. This observational study aimed to investigate the factors impeding this simple practice at the bedside.

[Distribution and sources of arsenic in Yangzonghai Lake, China].

By collecting water and sediment samples from Yangzonghai Lake and analyzing the total amount and speciation of arsenic, the spatial distribution of arsenic in surface water and sediments was analyzed, the current status of arsenic pollution were estimated, the anthropogenic contribution rate and the arsenic reserve in the lake were calculated respectively. Meanwhile, the sources of arsenic were investigated. The results indicated that the total arsenic content in Yangzonghai Lake was 71.