Dauricine alleviates cognitive impairment in Alzheimer's disease mice induced by D-galactose and AlCl via the Ca/CaM pathway.

Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly. Dysregulation of intracellular Ca homeostasis plays a critical role in the pathological development of AD. Dauricine (DAU) is a bisbenzylisoquinoline alkaloid isolated from Menispermum dauricum DC.

Total alkaloids from the seed embryo of Gaertn. improve cognitive impairment in APP/PS1 mice and protect Aβ-damaged PC12 cells.

The seed embryo of Gaertn. is a famous traditional Chinese medicine and food which is considered conducive to the prevention of Alzheimer's disease (AD). In this study, the effect and mechanism of TASENN (total alkaloids from the seed embryo of Gaertn.

Protective effects of Liensinine, Isoliensinine, and Neferine on PC12 cells injured by amyloid-β.

Excessive accumulation of amyloid-β (Aβ) is the leading cause of Alzheimer's disease (AD). Liensinine, Isoliensinine, and Neferine are main alkaloids in lotus seed embryos. In this paper, the protective effects of Liensinine, Isoliensinine, and Neferine on Aβ -injured PC12 cells were studied.