Publications by authors named "Jing-Song Cao"
Abnormal activation of macrophage and gut Bacteroides fragilis (BF) are the important induction factors in the occurrence of type 2 diabetes (T2D) and vascular complications. However, it remains unknown whether BF involves in macrophage polarization. In this study, we found that BF extracellular vesicles (EV) can be uptaken by macrophage.
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- Pravastatin, a common lipid-lowering drug for diabetes patients, is linked to increased vascular calcification (VC), but its mechanisms remain unclear.
- This study used various methods like 16S rRNA sequencing and flow cytometry to investigate gut bacteria and metabolites, revealing a significant rise in Bacteroides fragilis (BF) among pravastatin users and T2D mice treated with the drug.
- The research concluded that pravastatin enhances the secretion of 3,4,5-trimethoxycinnamic acid (TMCA) from BF, which subsequently promotes macrophage M1 polarization, a factor believed to contribute to VC in type 2 diabetes cases.