Publications by authors named "Jing-Si Dong"
Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, showing a significant number of mutations, averaging 82 non-silent mutations per tumor across the studied samples.
- The mutational profile is similar to squamous cell carcinomas in other areas but differs from esophageal adenocarcinoma, with 99% of cases showing mutations in critical genes regulating the cell cycle and apoptosis, particularly TP53 and CCND1.
- Key mutations in histone modifier genes and dysregulation of the Hippo and Notch pathways suggest important prognostic implications, with specific mutations linked to poorer survival rates in patients.
Objective: To investigate the efficacy of surgical treatment of sternal tumors and repairing methods of the chest wall defects.
Methods: Fifteen patients with sternal tumors were diagnosed and underwent resection of the sternal tumors according to the en-bolck principle and repair of the chest wall defects using various materials from January 1968 to December 2010 in our hospital.
Results: Of 6 patients with sternal manubrim tumors, one patient had reconstruction only with steel wire, other 5 patients healed completely after repair with soft materials.
[Comparison of the results of lymph node dissection via left versus right thoracotomy].
Zhonghua Zhong Liu Za Zhi
April 2012
Objective: Up to now surgical treatment has been still the most effective treatment for esophageal cancer. However, postoperative lymph node recurrence is still a frequent event and affects long term survival considerably. The aim of this study is to compare the results of lymph node dissection via left vs.
View Article and Find Full Text PDFBackground: It is still unclear whether pulmonary function tests (PFTs) are sufficient for predicting perioperative risk, and whether all patients or only a subset of them need a cardiopulmonary exercise test (CPET) for further assessment. Thus, this study was designed to evaluate the CPET and compare the results of CPET and conventional PFTs to identify which parameters are more reliable and valuable in predicting perioperative risks for high risk patients with lung cancer.
Methods: From January 2005 to August 2008, 297 consecutive lung cancer patients underwent conventional PFTs (spirometry + single-breath carbon monoxide diffusing capacity of the lungs (DLCOsb) for diffusion capacity) and CPET preoperatively.