[Relationship Between Carbon Emissions and Economic Development of Industrial Parks Based on Decoupling Index].

Industrial parks are the main carriers of industrial activities and are also key areas for carbon emissions. To deeply explore the decoupling state of carbon emissions and economic development of industrial parks and the driving forces, Zhengzhou Economic Development Zone were taken as example, based on the energy consumption data of industrial enterprises above a designated size from 2011 to 2020, the IPCC carbon emission accounting method, Tapio decoupling model, and logarithmic mean Divisia index decomposition method were used to analyze the characteristics of carbon emissions from energy consumption in the park, the relationship between carbon emissions and economic development, and the driving factors of decoupling. The results showed that:① in terms of carbon emission characteristics, the carbon emissions of energy consumption in Zhengzhou Economic Development Zone were mainly indirect carbon emissions, and the total carbon emissions showed a trend of rapid growth in the early stage, slowing down in the medium term, and negative growth in the later stage.

Metabolomics in renal cell carcinoma: From biomarker identification to pathomechanism insights.

Renal cell carcinoma (RCC) is a frequently diagnosed cancer with high prevalence, which is inversely associated with survival benefit. Although myriad studies have shed light on disease causality, unfortunately, thus far, RCC diagnosis is faced with numerous obstacles partly due to the insufficient knowledge of effective biomarkers, hinting deeper mechanistic understanding are urgently needed. Metabolites are recognized as final proxies for gene-environment interactions and physiological homeostasis as they reflect dynamic processes that are ongoing or have been taken place, and metabolomics may therefore offer a far more productive and cost-effective route to disease discovery, particularly within the arena for new biomarker identification.

Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation.

The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and maintaining intestinal homeostasis both in health and in disease state. Many effects are mediated by gut microbiota-derived metabolites and tryptophan, an essential aromatic amino acid, is considered important among many metabolites in the crosstalk between gut microbiota and the host. Kynurenine, serotonin, and indole derivatives are derived from the three major tryptophan metabolism pathways modulated by gut microbiota directly or indirectly.

Natural products against renin-angiotensin system for antifibrosis therapy.

Fibrosis is a final pathological feature of many chronic diseases, but few interventions are available that specifically target the pathogenesis of fibrosis. The highlights of common cellular and molecular mechanisms of fibrosis facilitate the discovery of effective antifibrotic drugs. The renin-angiotensin system (RAS) plays a central physiological role in the control of blood pressure and fluid homeostasis.

Unilateral ureteral obstruction causes gut microbial dysbiosis and metabolome disorders contributing to tubulointerstitial fibrosis.

Chronic kidney disease (CKD) increases the risk and prevalence of cardiovascular disease (CVD) morbidity and mortality. Recent studies have revealed marked changes in the composition of the microbiome and the metabolome and their potential influence in renal disease and CVD via the accumulation of microbial-derived uremic toxins. However, the effect of unilateral ureteral obstruction (UUO) on the gut microbiome and circulating metabolites is unknown.

Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis.

Renal ischemia-reperfusion injury (IRI) is a complex syndrome, which causes chronic kidney disease (CKD) after recovery from IRI-mediated acute kidney injury (AKI). There is no single therapy that could effectively prevent the renal injury after ischemia. In this study, the effects of melatonin or poricoic acid A (PAA) and their combination were investigated in protecting against AKI-to-CKD transition in rats and hypoxia/reoxygenation (H/R)-induced injury in cultured renal NRK-52E cells.

Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review.

Rhaponticin is a stilbenoid glucoside compound, found in medicinal plant of rhubarb rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has shown various biological activities including anticancer activities to act a potential human cytochrome P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial activities. Moreover, it was reported to scavenge intracellular Reactive Oxygen Species (ROS), the 1,1-Diphenyl-2-Picrylliydrazyl (DPPH) radical, and Hydrogen Peroxide (H2O2).

Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation.

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.

Withaferin A (WFA) is one of the most active steroidal lactones with reactive oxygen species (ROS) modulating effects against several types of cancer. ROS regulation involves selective killing. However, the anticancer and selective killing effects of WFA against oral cancer cells remain unclear.

Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells.

We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. The functional role of oxidative stress in the cell-killing effect of sinuleptolide on oral cancer cells was not investigated as yet. To address this question, we introduced the reactive oxygen species (ROS) scavenger (-acetylcysteine [NAC]) in a pretreatment to evaluate the sinuleptolide-induced changes to cell viability, morphology, intracellular ROS, mitochondrial superoxide, apoptosis, and DNA damage of oral cancer cells (Ca9-22).

[Temporal and Spatial Dynamics of Greenhouse Gas Emissions and Its Controlling Factors in a Coastal Saline Wetland in North Jiangsu].

Although coastal wetlands play an important role in governing the atmospheric concentrations of CO, CH, and NO, thus control the global warming, research of the greenhouse gas emissions conducted in the coastal wetlands were not well-documented because of the difficulty in fieldwork in these harsh environments, and the complicated controlling factors affecting the greenhouse gas emissions. The temporal and spatial variations of CO, CH, and NO were investigated simultaneously in the coastal saline wetland in North Jiangsu during the period from April, 2014 to March, 2014, using the closed static dark chamber method. And the results showed that seasonal variations of CO, CH, and NO were higher in summer, and lower CO and NO fluxes were observed in winter, while for CH in spring, it presented the sink in the coastal wetland.

Butanol-Partitioned Extraction from Aqueous Extract of Gracilaria tenuistipitata Inhibits Cell Proliferation of Oral Cancer Cells Involving Apoptosis and Oxidative Stress.

We have previously found that the aqueous extract of Gracilaria tenuistipitata (AEGT) and its partitioned fractions had antioxidant properties in biochemical assays. Although the butanol-partitioned fraction of AEGT (AEGT-pBuOH) had a stronger antioxidant performance than AEGT, its biological effects are still unknown. In this study, the cellular responses of oral cancer cells to AEGT-pBuOH were monitored in terms of cell viability, cell cycle progression, apoptosis, and oxidative stress responses.

Sinuleptolide inhibits proliferation of oral cancer Ca9-22 cells involving apoptosis, oxidative stress, and DNA damage.

Objective: Sinuleptolide, a soft corals-derived bioactive norditerpenoid, is a marine natural product with a potent anti-inflammatory effect. We evaluate the potential anti-oral cancer effects of sinuleptolide and investigate the possible mechanisms involved.

Designs: Cell viability, cell cycle, apoptosis, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and DNA damage analyses were performed.

[Functional analysis of autism-associated NRXN1β gene promoter].

Neurexins are neuron-specific synaptic proteins, and abnormal structure of Neurexin1β is closely associated with autism. To characterize the minimal promoter of autism-associated NRXN1β gene and identify functional elements regulating its transcription, luciferase reporter plasmids containing different regulatory regions upstream of NRXN1β gene were constructed. After transfecting HEK293 cells with these plasmids, the minimal promoter region of NRXN1β gene was determined by detecting the transcriptional activity of luciferase reporter genes while the corresponding functional elements that significantly enhance or inhibit the activity of reporter genes were further screened out.

Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells.

Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells.

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers.

Research concerning the epigenome over the years has systematically and sequentially shown substantial development and we have moved from global inhibition of modifications of the epigenome toward identification and targeted therapy against tumor-specific epigenetic mechanisms. In accordance with this approach, several drugs with epigenetically modulating activity have received considerable attention and appreciation, and recently emerging scientific evidence is uncovering details of their mode of action. High-throughput technologies have considerably improved our existing understanding of tumor suppressors, oncogenes, and signaling pathways that are key drivers of cancer.

[Emission spectrum temperature sensitivity of Mg4FGeO6 : mn induced by laser].

In order to develop a new sort of thermally sensitive phosphor coating, the emission spectrum thermally sensitivity of Mg4FGeO6 : Mn induced by laser was studied. The spectrum measurement system with heating function was set up, and the emission spectrum of Mg4FGeO6 : Mn at various temperatures were measured. Absorption spectrum was measured, and the mechanism of formation of the structure of double peak was analyzed with the perturbation theory of crystal lattice.

[Study on effect of hyperbranched polyester on the mechanical properties and morphology of PEG polyurethane elastomer by ATR-FTIR].

In order to enhance the mechanical properties of polyethylene glycol (PEG) polyurethane elastomer, the modified hyperbranched polyester (HBP) was introduced. The chemical structures of HBP/PEG polyurethane films were analyzed by attenuated total reflection-Fourier transfoum infrared spectrum (ATR-FTIR). The results indicate that with the modified hyperbranched polyester added, the tensile strength and elongation at break of PEG polyurethane elastomer are improved obviously.

[Integrating technologies for urban communities' municipal solid waste minimization].

Municipal solid waste management of urban communities has difficulties of insufficient source separation and food waste's high moisture content, an integrating technology of manual separation, simple compression of food waste, reclaim of food waste and composting leachate was studied. Manual separating rate was 36.8 kg/h, and would increase when the worker became sophisticated.

10 J energy-level optically pumped XeF(C-A) laser with repetition mode.

An optically pumped XeF(C-A) laser with 0.1-1 Hz pulse-repetition mode is demonstrated. The maximum output energy is up to 18.

[Adaptive changes in activity of tonoplast H(+)-ATPase from the roots of tomato seedlings under phosphorus starvation].

We studied the growth state of tomato seedlings and the adaptive changes in activity of tonoplast H(+)-ATPase on different days (5 d, 7 d, 9 d, 11 d, 13 d) sampling from the roots of tomato seedlings under phosphorus starvation. The results indicated that the average height of the seedlings decreased under phosphorus starvation, while the main roots of the seedlings were significantly longer than those of the control. The phosphorus uptake rates of tomato seedlings under phosphorus starvation significantly increased and were much higher than those of controls and reached maximum values under the starvation for 7 days.

Life cycle assessment of mobile phone housing.

The life cycle assessment of the mobile phone housing in Motorola(China) Electronics Ltd. was carried out, in which materials flows and environmental emissions based on a basic production scheme were analyzed and assessed. In the manufacturing stage, such primary processes as polycarbonate molding and surface painting are included, whereas different surface finishing technologies like normal painting, electroplate, IMD and VDM etc.