Publications by authors named "Jing-Rong Jhuang"
Article Synopsis
- The study aimed to investigate the impact of local corticosteroids on swallowing difficulties (dysphagia) in patients who underwent anterior cervical discectomy and fusion (ACDF), using advanced methods to analyze swallowing function.
- Patients were divided into two groups: one receiving local triamcinolone (corticosteroids) and the other receiving saline solution, and their swallowing function was assessed before and one month after surgery.
- Results indicated that while there was no difference in swallowing function before surgery, the corticosteroid group had significantly lower upper esophageal sphincter relaxation pressure post-operation compared to the saline group, but overall swallowing assessments showed no major adverse effects.
Background: Colorectal cancer remains a major global public health challenge. Its incidence is shaped by a complex interplay of screening programmes and age, period and cohort factors.
Methods: We introduce a novel Age-Period-Cohort-Screening (APCS) model to analyse trends in colorectal cancer incidence in Taiwan from 2000 to 2019.
Article Synopsis
- The study investigates the long-term outcomes of laparoscopic versus open surgery for colorectal cancer in obese patients (BMI ≥ 30 kg/m²) using data from 2009-2019, aiming to find better surgical options.
- Laparoscopic surgery showed longer operation times and higher complication rates, while open surgery had more wound infections and readmissions; however, laparoscopic surgery was linked to worse long-term survival and recurrence rates, especially in certain patient subgroups.
- The authors conclude that laparoscopic colorectal surgery in obese patients has significant risks despite short-term benefits, recommending caution for specific groups like older patients and those with advanced cancer stages.
Predicting Lung Cancer Survival to the Future: Population-Based Cancer Survival Modeling Study.
JMIR Public Health Surveill
May 2024
Background: Lung cancer remains the leading cause of cancer-related mortality globally, with late diagnoses often resulting in poor prognosis. In response, the Lung Ambition Alliance aims to double the 5-year survival rate by 2025.
Objective: Using the Taiwan Cancer Registry, this study uses the survivorship-period-cohort model to assess the feasibility of achieving this goal by predicting future survival rates of patients with lung cancer in Taiwan.
Context: The association between colorectal cancer (CRC) and new-onset diabetes mellitus remains unclear.
Objective: To examine the association between CRC and the risk of subsequent diabetes mellitus and to further investigate the impact of chemotherapy on diabetes mellitus risk in CRC.
Design: A nationwide cohort study.
Background: The World Health Organization aims for the global elimination of cervical cancer, necessitating modeling studies to forecast long-term outcomes.
Objective: This paper introduces a macrosimulation framework using age-period-cohort modeling and population attributable fractions to predict the timeline for eliminating cervical cancer in Taiwan.
Methods: Data for cervical cancer cases from 1997 to 2016 were obtained from the Taiwan Cancer Registry.
Background: Early detection of dysphagia is important for preventing aspiration pneumonia. Although videofluoroscopy is currently the primary diagnostic tool for dysphagia, access to this tool may be limited because of radiation exposure risk, high cost, and other factors.
Purpose: In this study, a meta-analysis was used to determine the strength of the correlation between dysphagia detection outcomes obtained using subjective questionnaires and videofluoroscopy.
Background: Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence.
Methods: By using the Taiwan Cancer Registry dataset, we enrolled patients aged 40-84 diagnosed with arsenic-related cancers, including hepatocellular carcinoma, small and squamous cell lung cancer, Bowen's disease, basal and squamous cell skin cancer, urothelial bladder cancer, and upper tract urothelial carcinoma between 1995 and 2019.
Article Synopsis
- * Data were collected from 1,528 AP patients between 2015 and 2018, with only a small percentage (6.3%) using NSAIDs during a crucial time frame around their diagnosis.
- * The analysis found no significant link between NSAID use and the rates of OF or persistent OF, suggesting that NSAIDs did not reduce these complications in AP patients.
Article Synopsis
- * Researchers followed breast cancer patients diagnosed between 2007 and 2016 in Taiwan and compared their health outcomes to a general population over time.
- * Findings revealed a higher CAD risk shortly after diagnosis but no link between radiotherapy and increased CAD or stroke risk.
Background: Although diabetes is a poor prognostic factor for colorectal cancer (CRC), whether diabetes severity provides an additional predictive value for CRC prognosis remains unclear. The study aimed to investigate the prognostic differences after curative CRC resection among patients with different diabetic severities.
Methods: This population-based retrospective cohort study analyzed data registered between 2007 and 2015 in the Cancer Registry Database, which is linked to the National Health Insurance Research Database and National Death Registry.
Background: This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population.
Methods: We used the National Taiwan Cancer Registry Database to construct a cohort of patients with parathyroid cancer from January 1, 2004, to December 31, 2019. We compared the incidence of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, coronary heart disease, and heart failure with the general population matched based on a propensity score in a one-to-five fashion.
Purpose: Aristolochic acid (AA) is a carcinogen in upper urinary tract urothelial carcinoma (UTUC). This study investigated the latency period between AA exposure and UTUC development.
Materials And Methods: This population-based cohort study was designed using record linkage of the National Health Insurance Research Database (NHIRD), Taiwan Cancer Registry Dataset, and cause-of-death data in Taiwan.
Article Synopsis
- * A study analyzing data from the Taiwan Cancer Registry from 1997-2016 revealed that urban women had higher breast cancer rates than rural women, though rural rates increased more rapidly over time.
- * The research indicates that women born in 1992 faced significantly higher breast cancer risks compared to earlier cohorts, suggesting that urbanization and westernization may be contributing factors to changing incidence rates in Taiwan.
Article Synopsis
- * An analysis revealed that while lung adenocarcinoma rates are increasing, lung squamous cell carcinoma rates are declining, especially among women in recent birth cohorts.
- * Geographic hotspots for lung adenocarcinoma are predominantly found in northern, northeastern, and western coastal areas, with rising concerns over pollution contributing to these trends.
Background: The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer.
Methods: Patients with common cancers in Taiwan were enrolled in the study between 2007 and 2018 using the Taiwan Cancer Registry.
Treatment with levothyroxine and radioiodine contribute alternative cardiovascular function in adults with thyroid cancer. The risks of long-term cardiovascular conditions among thyroid cancer patients is unknown. This study aimed to compare the incidence of coronary heart disease (CHD), ischemic stroke (IS), and atrial fibrillation (AF) among adults with thyroid cancer with that of the general population, especially when stratified by age (< 65 and ≥ 65 years old).
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- Mapping disease rates in spacetime helps us understand how they spread and change over time.
- Traditional methods can oversmooth or undersmooth results due to varying population densities, which the new stabilized spatiotemporal kriging method addresses by allowing for different variances.
- When applied to cancer rates in Taiwan, the method highlights high-risk areas for oral cancer in the midwestern and southeastern regions, while breast cancer risks are concentrated in urban areas in the west.
Article Synopsis
- Breast cancer is the most common cancer among women in Taiwan, with its incidence rate having doubled over the past 20 years, raising concerns among health professionals and the public.
- A study used advanced models to analyze breast cancer incidence trends from 1997 to 2016 and predict future trends, finding a rapid increase in age-standardized incidence rates, projected to reach a plateau by 2031.
- The majority of future breast cancer cases are expected to occur in women aged 55 and older, highlighting the need for education on lifestyle changes and regular mammography screening to mitigate the impact of the disease.
Article Synopsis
- Chronic infections from hepatitis B and C viruses are leading causes of end-stage liver disease (ESLD), and controlling these infections is crucial for reducing ESLD rates.
- A study in Taiwan analyzed the impact of nationwide neonatal hepatitis B vaccinations and antiviral therapy programs on ESLD from 1979 to 2018, including data from nearly 43,604 individuals.
- Results showed significant reductions in chronic liver disease and hepatocellular carcinoma (HCC) mortality and incidence from 2004 to 2018, with an 82% decrease in CLD mortality among those born between 1982 and 2011.
Article Synopsis
- * A study from 1997 to 2011 analyzed invasive breast cancer cases, revealing a significant cohort effect in South Korea, Taiwan, Japan, and Thailand, likely linked to westernization.
- * While an increase in breast cancer rates was observed in women born in Hong Kong and India, no birth cohort effect was seen in the Philippines or among ethnic groups in the U.S., highlighting differences in cultural influence on cancer trends.
Article Synopsis
- Oral cancer is a significant health issue in Taiwan, especially among men, with incidence rates rising sharply since 1980, peaking in 2014.
- A study analyzing data from 1997 to 2017 suggests that while recent trends show an increase in cases, younger adults and certain birth cohorts have already seen a decline in incidence.
- The research predicts an overall decrease of 8.4% in oral cancer rates among men from 2017 to 2025, highlighting the need for effective public health strategies for prevention and control.
Background: To investigate the standardized incidence ratios (SIR) of stroke in patients with head and neck cancer and their relationship to radiotherapy.
Methods: Patients with head and neck cancer ages 20-85 years were enrolled from 2007 to 2016 using the Taiwan Cancer Registry. The study endpoint was fatal and non-fatal ischemic stroke, ascertained by the National Health Insurance Research Database.
Researchers have conducted many studies about the relationships between peri-cardiovascular fat, nonalcoholic fatty liver disease (NAFLD), waist circumference, and cardiovascular disease (CVD). Nevertheless, the relationship between NAFLD and pericardial fat (PCF)/thoracic peri-aortic adipose tissue (TAT) phenotypes was still unknown. This study aimed to explore whether PCF/TAT was associated with NAFLD/abdominal obesity (AO) phenotypes in different high-sensitivity C-reactive protein (hs-CRP) levels.
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