Increased local miR-21 expressions are linked with clinical severity in lumbar disc herniation patients with sciatic pain.

Background: The miR-21 has been implicated in the process of neuroinflammation as well as neuropathic pain.

Objectives: To explore the relationship between the plasma and local expression of miR-21 with disease severity of lumbar disc herniation (LDH) patients with sciatic pain.

Material And Methods: Ninety-two LDH patients with sciatic pain and 25 scoliosis patients as painless controls were enrolled in the current study.